Results 11 to 20 of about 67,898 (346)

Evaluation of Serum Zonulin and Occludin Levels in Bipolar Disorder

Psychiatry Investigation, 2023
Objective The etiology of bipolar disorder (BD) is still not fully understood. Little is currently known about the relationship between the interaction the gastrointestinal system and brain function and BD.
Sertaç Zengil, Esra Laloğlu
semanticscholar   +5 more sources

Plasma Levels of Occludin and Claudin-5 in Acute Stroke Are Correlated with the Type and Location of Stroke but Not with the Neurological State of Patients—Preliminary Data

Brain Sciences, 2020
The blood–brain barrier is the structure (BBB), which isolates the central nervous system from the external environmental. During a stroke, the BBB gets damaged, which is accompanied by changes in the concentrations and distributions of claudin-5 ...
Anetta Lasek-Bal, Anna Kokot, Daria Gendosz de Carrillo, Sebastian Student, Katarzyna Pawletko, Aleksandra Krzan, Przemysław Puz, Wiesław Bal, Halina Jędrzejowska-Szypułka   +8 more
doaj   +2 more sources

PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway

Acta Biochimica et Biophysica Sinica, 2023
Prolyl hydroxylase 3 (PHD3) hydroxylates HIFα in the presence of oxygen, leading to HIFα degradation. PHD3 inhibits tumorigenesis. However, the underlying mechanism is not well understood. Herein, we demonstrate that PHD3 inhibits the metastasis of colon
Li Yuyao, Yuan Tanglong, Zhang Hongwei, Liu Shuting, Lun Jie, Guo Jing, Wang Yu, Zhang Yuying, Fang Jing   +8 more
doaj   +2 more sources

Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival

Annals of the New York Academy of Sciences, 2022
Epithelial cells are the first line of mucosal defense. In the intestine, a single layer of epithelial cells must establish a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing the leakage of potentially ...
W. Kuo, Matthew A. Odenwald, J. Turner, Li Zuo   +3 more
semanticscholar   +1 more source

The tight junction protein occludin modulates blood–brain barrier integrity and neurological function after ischemic stroke in mice

Scientific Reports, 2023
Blood–brain barrier (BBB) disruption contributes to brain injury and neurological impairment. Tight junctions (TJs) and cell–cell adhesion complexes develop between endothelial cells in the brain to establish and maintain the BBB.
Shintaro Sugiyama, Tsutomu Sasaki, Hiroo Tanaka, Haomin Yan, Takeshi Ikegami, H. Kanki, Kumiko Nishiyama, G. Beck, Y. Gon, Shuhei Okazaki, K. Todo, A. Tamura, S. Tsukita, H. Mochizuki   +13 more
semanticscholar   +1 more source

Preventing occludin tight-junction disruption via inhibition of microRNA-193b-5p attenuates viral load and influenza-induced lung injury

Molecular Therapy, 2023
Virus-induced lung injury is associated with loss of pulmonary epithelial-endothelial tight junction integrity. While the alveolar-capillary membrane may be an indirect target of injury, viruses may interact directly and/or indirectly with miRs to ...
C. Vaswani, Amir K. Varkouhi, Sahil Gupta, A. Ektesabi, J. Tsoporis, S. Yousef, P. Plant, Adriana L. da Silva, Y. Cen, Yi‐Chieh Tseng, S. Batah, A. Fabro, Suzanne L. Advani, A. Advani, H. Leong-Poi, J. Marshall, Cristiana C Garcia, P. Rocco, G. Albaiceta, Steffen Sebastian-Bolz, T. Watts, T. Moraes, V. Capelozzi, C. D. dos Santos   +23 more
semanticscholar   +1 more source

Occludin 1B, a Variant of the Tight Junction Protein Occludin [PDF]

Molecular Biology of the Cell, 2000
Occludin and claudin are the major integral membrane components of the mammalian tight junction. Although more than 11 distinct claudins have been identified, only 1 occludin transcript has been reported thus far. Therefore, we searched by reverse transcription–PCR for occludin-related sequences in Madin–Darby canine kidney (MDCK) mRNA and identified a
Z, Muresan, D L, Paul, D A, Goodenough
openaire   +2 more sources

Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function

Molecular Biology of the Cell, 2021
Tight junctions (TJs) are composed of a claudin-based anastomosing network of TJ strands at which plasma membranes of adjacent epithelial cells are closely attached to regulate the paracellular permeability.
Akira C Saito, T. Higashi, Y. Fukazawa, Tetsuhisa Otani, M. Tauchi, Atsuko Y. Higashi, M. Furuse, H. Chiba   +7 more
semanticscholar   +1 more source

Occludin Modulates Transepithelial Migration of Neutrophils [PDF]

Journal of Biological Chemistry, 2000
Neutrophils cross epithelial sheets to reach inflamed mucosal surfaces by migrating along the paracellular route. To avoid breakdown of the epithelial barrier, this process requires coordinated opening and closing of tight junctions, the most apical intercellular junctions in epithelia. To determine the function of epithelial tight junction proteins in
D, Huber, M S, Balda, K, Matter
openaire   +2 more sources

An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity.

Cell Reports, 2022
Tight junctions (TJs) of brain microvascular endothelial cells (BMECs) play a pivotal role in maintaining the blood-brain barrier (BBB) integrity; however, precise regulation of TJs stability in response to physiological and pathological stimuli remains ...
Yuan Li, Jia-Yi Wei, Hui Liu, Kang Wang, Sheng-Nan Jin, Zheng-Kang Su, Hui-Jie Wang, Jun-Xiu Shi, Bo Li, De-Shu Shang, Wen-Gang Fang, Xiao-Xue Qin, Wei-Dong Zhao, Yu-hua Chen   +13 more
semanticscholar   +1 more source