Results 11 to 20 of about 55,164 (304)
PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway
Acta Biochimica et Biophysica Sinica, 2023 Prolyl hydroxylase 3 (PHD3) hydroxylates HIFα in the presence of oxygen, leading to HIFα degradation. PHD3 inhibits tumorigenesis. However, the underlying mechanism is not well understood. Herein, we demonstrate that PHD3 inhibits the metastasis of colon
Li Yuyao +8 more
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Occludin 1B, a Variant of the Tight Junction Protein Occludin [PDF]
Molecular Biology of the Cell, 2000 Occludin and claudin are the major integral membrane components of the mammalian tight junction. Although more than 11 distinct claudins have been identified, only 1 occludin transcript has been reported thus far. Therefore, we searched by reverse transcription–PCR for occludin-related sequences in Madin–Darby canine kidney (MDCK) mRNA and identified a
Z, Muresan, D L, Paul, D A, Goodenough
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Occludin Modulates Transepithelial Migration of Neutrophils [PDF]
Journal of Biological Chemistry, 2000 Neutrophils cross epithelial sheets to reach inflamed mucosal surfaces by migrating along the paracellular route. To avoid breakdown of the epithelial barrier, this process requires coordinated opening and closing of tight junctions, the most apical intercellular junctions in epithelia. To determine the function of epithelial tight junction proteins in
D, Huber, M S, Balda, K, Matter
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Occludin immunolocalization and protein expression in goldfish [PDF]
Journal of Experimental Biology, 2008 SUMMARYTight junctions (TJs) are an integral component of models illustrating ion transport mechanisms across fish epithelia; however, little is known about TJ proteins in fishes. Using immunohistochemical methods and Western blot analysis, we examined the localization and expression of occludin, a transmembrane TJ protein, in goldfish tissues.
Helen, Chasiotis, Scott P, Kelly
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Frontiers in Physiology, 2020 The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding neurotoxic substances from the peripheral circulation.
Jeffrey J. Lochhead +3 more
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Pharmaceuticals, 2022 In order to promote gastrointestinal health, significant increases in the prevalence of gastrointestinal disorders should be paralleled by similar surges in therapeutics research.
L. Pretorius, C. Smith
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Animals, 2021 We investigated the efficacy of a single bacterium strain, Bacillus subtilis (B. subtilis) YW1, on the performance, morphology, cecal microbiota, and intestinal barrier function of laying hens.
Guangzhi Zhang +12 more
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Loss of Occludin Affects Tricellular Localization of Tricellulin [PDF]
Molecular Biology of the Cell, 2008 The tricellular tight junction (tTJ) forms at the convergence of bicellular tight junctions (bTJs) where three epithelial cells meet in polarized epithelia, and it is required for the maintenance of the transepithelial barrier. Tricellulin is a four transmembrane domain protein recently identified as the first marker of tTJ, but little is known about ...
Junichi, Ikenouchi +4 more
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Occludin Localizes to Centrosomes and Modifies Mitotic Entry [PDF]
Journal of Biological Chemistry, 2011 Proper control of cell cycle progression and barrier function are essential processes to the maintenance of epithelial cell homeostasis. The contribution of tight junction proteins to barrier function is well established, whereas their contribution to cell cycle control is only beginning to be understood.
E Aaron, Runkle +4 more
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Pharmaceuticals, 2022 Inflammatory bowel diseases (IBD) are digestive tract disorders that involve chronic inflammation with frequent recurrences. This study aimed to evaluate the efficacy of two novel histone deacetylase 8 (HDAC8) inhibitors, namely, SPA3052 and SPA3074 ...
Ji-In Yoon +3 more
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