Results 21 to 30 of about 67,898 (346)
Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes
Diabetes, 2021 Diabetic retinopathy is one of the leading causes of vision loss and blindness. Extensive preclinical and clinical evidence exists for both vascular and neuronal pathology.
A. Goncalves +7 more
semanticscholar +1 more source
Occludin immunolocalization and protein expression in goldfish [PDF]
Journal of Experimental Biology, 2008 SUMMARYTight junctions (TJs) are an integral component of models illustrating ion transport mechanisms across fish epithelia; however, little is known about TJ proteins in fishes. Using immunohistochemical methods and Western blot analysis, we examined the localization and expression of occludin, a transmembrane TJ protein, in goldfish tissues.
Helen, Chasiotis, Scott P, Kelly
openaire +2 more sources
Frontiers in Physiology, 2020 The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding neurotoxic substances from the peripheral circulation.
Jeffrey J. Lochhead +3 more
doaj +1 more source
Pharmaceuticals, 2022 In order to promote gastrointestinal health, significant increases in the prevalence of gastrointestinal disorders should be paralleled by similar surges in therapeutics research.
L. Pretorius, C. Smith
doaj +1 more source
Loss of Occludin Affects Tricellular Localization of Tricellulin [PDF]
Molecular Biology of the Cell, 2008 The tricellular tight junction (tTJ) forms at the convergence of bicellular tight junctions (bTJs) where three epithelial cells meet in polarized epithelia, and it is required for the maintenance of the transepithelial barrier. Tricellulin is a four transmembrane domain protein recently identified as the first marker of tTJ, but little is known about ...
Junichi, Ikenouchi +4 more
openaire +2 more sources
Animals, 2021 We investigated the efficacy of a single bacterium strain, Bacillus subtilis (B. subtilis) YW1, on the performance, morphology, cecal microbiota, and intestinal barrier function of laying hens.
Guangzhi Zhang +12 more
doaj +1 more source
Scientific Reports, 2020 Cognitive impairment is a well-known complication of diabetes mellitus (DM). Microvascular compromise was described one DM complication. Recently we showed blood brain barrier (BBB) permeability and memory loss are associated with diminution of tight ...
Slava Rom +5 more
semanticscholar +1 more source
Occludin Localizes to Centrosomes and Modifies Mitotic Entry [PDF]
Journal of Biological Chemistry, 2011 Proper control of cell cycle progression and barrier function are essential processes to the maintenance of epithelial cell homeostasis. The contribution of tight junction proteins to barrier function is well established, whereas their contribution to cell cycle control is only beginning to be understood.
E Aaron, Runkle +4 more
openaire +2 more sources
Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inflammatory Response and Tight Junction-Related Protein in Lipopolysaccharide-Stimulated Caco-2 Cells. [PDF]
, 2019 In the normal physiological state, intestinal epithelial cells act as a defensive frontline of host mucosal immunity to tolerate constant exposure to external stimuli.
Ding +13 more
core +1 more source
Pharmaceuticals, 2022 Inflammatory bowel diseases (IBD) are digestive tract disorders that involve chronic inflammation with frequent recurrences. This study aimed to evaluate the efficacy of two novel histone deacetylase 8 (HDAC8) inhibitors, namely, SPA3052 and SPA3074 ...
Ji-In Yoon +3 more
doaj +1 more source