A fixed combination of probiotics and herbal extracts attenuates intestinal barrier dysfunction from inflammatory stress in an in vitro model using Caco-2 cells. [PDF]
, 2019 Background: Inflammatory Bowel Diseases (IBD), are considered a growing global disease, with about ten million people being affected worldwide. Maintenance of intestinal barrier integrity is crucial for preventing IBD onset and exacerbations. Some recent
Biagi, M +8 more
core +1 more source
Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]
, 2019 Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland +8 more
core +1 more source
Frontiers in Nutrition, 2021 Weaning piglets experienced the transformation from breast milk to solid feed and present the proliferation of pathogens, the presence of diarrhea, poor growth performance and even death.
Zhenguo Yang +7 more
doaj +1 more source
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]
, 2017 Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo +13 more
core +2 more sources
Frontiers in Cell and Developmental Biology, 2021 This study aimed to determine whether Bmi-1 deficiency leads to intestinal epithelial barrier destruction and microbiota dysfunction, which members of the microbial community alter barrier function with age, and whether p16INK4a deletion could reverse ...
Jiawen Zhou +14 more
doaj +1 more source
Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]
, 2019 Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica +6 more
core +1 more source
Laminaria japonica Extract Enhances Intestinal Barrier Function by Altering Inflammatory Response and Tight Junction-Related Protein in Lipopolysaccharide-Stimulated Caco-2 Cells. [PDF]
, 2019 In the normal physiological state, intestinal epithelial cells act as a defensive frontline of host mucosal immunity to tolerate constant exposure to external stimuli.
Ding +13 more
core +1 more source
Low Expression of Occludin in the Melanoma Patient [PDF]
Iranian Journal of Pathology, 2019 Background & Objective: Malignant melanoma is the fatal cutaneous neoplasm which is curable by the early diagnosis. The expression of occludin protein which is an integral membrane protein is altered in an epithelial-to-mesenchymal transition. Although, recent studies provide sufficient evidence supporting the functional importance of occludin in ...
Salehi, Pouri +2 more
openaire +2 more sources
Sari Pediatri, 2022 Latar belakang. Obesitas berhubungan dengan perubahan komposisi mikrobiota usus yang dapat mengganggu integritas usus. Protein pengikat tight junction, occludin, ekspresinya berkurang saat integritas usus terganggu. Probiotik dilaporkan dapat memperbaiki
Mira Mariana Ulfah +1 more
doaj +1 more source
Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission [PDF]
, 2010 Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission. In this study we use a novel infectious coculture system to examine these alternative modes of infection.
Balfe, Peter +12 more
core +4 more sources