Results 41 to 50 of about 55,164 (304)

The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]

, 2020
The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita, Foretz, Marc, Ghosh, Pradipta, Ibeawuchi, Stella-Rita, Lim, Blaze B, Mittal, Yash, Sahoo, Debashis, Sayed, Ibrahim M, Swanson, Lee, Viollet, Benoit   +9 more
core   +3 more sources

Occludin Regulates Actin Cytoskeleton in Endothelial Cells.

Cell Structure and Function, 2001
Occludin is a major membrane component of tight junctions of endothelial cells, though the role of this molecule is not fully understood. RLE cells, derived from rat lung endothelial cells, express a negligible level of occludin with clear expression of E-cadherin and ZO-1 at cell junctions.
H, Kuwabara, Y, Kokai, T, Kojima, R, Takakuwa, M, Mori, N, Sawada   +5 more
openaire   +3 more sources

Dynamic migration of γδ intraepithelial lymphocytes requires occludin [PDF]

Proceedings of the National Academy of Sciences, 2012
γδ intraepithelial lymphocytes (IELs) are located beneath or between adjacent intestinal epithelial cells and are thought to contribute to homeostasis and disease pathogenesis. Using in vivo microscopy to image jejunal mucosa of GFP γδ T-cell transgenic mice, we discovered that γδ IELs migrate actively within the intraepithelial compartment and into ...
Karen L, Edelblum, Le, Shen, Christopher R, Weber, Amanda M, Marchiando, Bryan S, Clay, Yingmin, Wang, Immo, Prinz, Bernard, Malissen, Anne I, Sperling, Jerrold R, Turner   +9 more
openaire   +2 more sources

Zonula occludin toxin, a microtubule binding protein

World Journal of Gastroenterology, 2000
AIM:To investigate the interaction of Zot with microtubule.METHODS:Zot affinity column was applied to purify Zot-binding protein(s) from crude intestinal cell lysates. After incubation at room temperature, the column was washed and the proteins bound to the Zot affinity column were eluted by step gradient with NaCl (0.3molcenter dotL(-1) -0.5molcenter ...
Wen-Le, Wang, Rui-Liang, Lu, MariaRosaria, DiPierro, Alessio, Fasano   +3 more
openaire   +2 more sources

Occludin and hydromineral balance inXenopus laevis [PDF]

Journal of Experimental Biology, 2009
SUMMARYTo investigate the response of the tight junction (TJ) protein occludin to environmental change in an anuran amphibian, we examined occludin tissue distribution, immunolocalization and alterations in mRNA expression in African clawed frogs (Xenopus laevis) acclimated to brackish water (BW)conditions (from freshwater to 2‰, 5‰ or 10‰ salt water).
Helen, Chasiotis, Scott P, Kelly
openaire   +2 more sources

Enhancing Blood–Brain Barrier Integrity in Patients With Acute Ischemic Stroke Via Normobaric Hyperoxia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
BACKGROUND Recent advancements in animal studies have demonstrated the potential of normobaric hyperoxia (NBO) as a promising intervention for preserving the integrity of the blood–brain barrier (BBB). However, there is still limited understanding of the
Weili Li, Wenbo Hu, Shuhua Yuan, Jiahao Chen, Qi Wang, Jiayue Ding, Zhiying Chen, Zhifeng Qi, Ju Han   +8 more
doaj   +1 more source

Expression of Endothelial NOX5 Alters the Integrity of the Blood-Brain Barrier and Causes Loss of Memory in Aging Mice

Antioxidants, 2021
Blood-Brain barrier (BBB) disruption is a hallmark of central nervous system (CNS) dysfunction, and oxidative stress is one of the molecular mechanisms that may underlie this process.
Adriana Cortés, Maite Solas, Álvaro Pejenaute, Miguel A. Abellanas, Marcos Garcia-Lacarte, Maria S. Aymerich, Javier Marqués, María J. Ramírez, Guillermo Zalba   +8 more
doaj   +1 more source

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice [PDF]

, 2016
The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection.
Andrews, Zane B., Austin, Victoria, Barsby, Tom, Chin, Kai Yee, Ku, Jacqueline M., Miller, Alyson A., Spencer, Sarah J., Taher, Mohammadali, Wong, Connie H.Y.   +8 more
core   +1 more source

Occludin S471 Phosphorylation Contributes to Epithelial Monolayer Maturation [PDF]

Molecular and Cellular Biology, 2016
Multiple organ systems require epithelial barriers for normal function, and barrier loss is a hallmark of diseases ranging from inflammation to epithelial cancers. However, the molecular processes regulating epithelial barrier maturation are not fully elucidated.
Mark T. Bolinger, Aniket Ramshekar, Helen V. Waldschmidt, Scott D. Larsen, Maria C. Bewley, John M. Flanagan, David A. Antonetti   +6 more
openaire   +2 more sources

Bletilla striata polysaccharides ameliorates lipopolysaccharide-induced injury in intestinal epithelial cells

The Saudi Journal of Gastroenterology, 2019
Background/Aims: This study was carried out to investigate the effect of Bletilla striata polysaccharide (BSP) treating on lipopolysaccharide (LPS)-induced intestinal epithelial barrier disruption in rat intestinal epithelial cell (IEC) line.
Lei Luo, Yuqing Liu, Xin Cai, Yao Wang, Juan Xue, Juan Zhang, Fan Yang   +6 more
doaj   +1 more source