Results 51 to 60 of about 67,898 (346)

Compromised barrier integrity of human feto-placental vessels from gestational diabetic pregnancies is related to downregulation of occludin expression

Diabetologia, 2020
Aims/hypothesis Reduced occupancy of junctional occludin is a feature of human placental vessels in the diabetic milieu. However, the functional consequence of this and whether this loss is due to differential expression of occludin splice variants is ...
Stephany D. Villota, Maria Toledo-Rodriguez, L. Leach   +2 more
semanticscholar   +1 more source

Aerobic training improves blood-brain barrier and neuronal apoptosis in experimental autoimmune encephalomyelitis [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Blood-brain barrier (BBB) permeability is central in multiple sclerosis (MS) pathophysiology, and exercise may improve BBB integrity. The current study investigated the prophylactic and/ or therapeutic role of aerobic exercise (EX) training
Omid Razi, Abdolhossein Parnow, Iraj Rashidi, Nafiseh Pakravan, Seyed Ershad Nedaei, Robert Motl   +5 more
doaj   +1 more source

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal [PDF]

, 2018
Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases.
Battistelli, Cecilia, Bordoni, Veronica, DE TURRIS, Valeria, Domenici, Alessandro, Mai, Antonello, Manzione, Andrea, Mene', Paolo, Moioli, Alessandra, Noce, Valeria, Palladino, Marco, Rossi, Lucia, Strippoli, Raffaele, Tripodi, Marco, Valente, Sergio, Zwergel, Clemens   +14 more
core   +1 more source

Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke [PDF]

Avicenna Journal of Phytomedicine
Objective: Brain ischemia generally results in irreversible brain damage or death. One of the most important features of an ischemic stroke is disruption of the Blood-brain barrier (BBB).
Solmaz Najjary, Hossein Mostafavi, Hadi Feizi, Fatemeh Moradi, Mehdi Eskandari   +4 more
doaj   +1 more source

Serum Occludin as a Biomarker to Predict the Severity of Acute Ischemic Stroke, Hemorrhagic Transformation, and Patient Prognosis

Aging and Disease, 2020
Blood-brain barrier (BBB) damage plays an important role in overall brain injury following acute ischemic stroke (AIS). We investigated the potential utility of serum occludin, a BBB damage biomarker, in predicting the severity of AIS, hemorrhagic ...
Weili Li, Zhifeng Qi, Huining Kang, Xuzhen Qin, Haiqing Song, Xueqin Sui, Yi Ren, X. Ji, Qingfeng Ma, K. Jian Liu   +9 more
semanticscholar   +1 more source

Occludin Regulates Actin Cytoskeleton in Endothelial Cells.

Cell Structure and Function, 2001
Occludin is a major membrane component of tight junctions of endothelial cells, though the role of this molecule is not fully understood. RLE cells, derived from rat lung endothelial cells, express a negligible level of occludin with clear expression of E-cadherin and ZO-1 at cell junctions.
H, Kuwabara, Y, Kokai, T, Kojima, R, Takakuwa, M, Mori, N, Sawada   +5 more
openaire   +3 more sources

Dynamic migration of γδ intraepithelial lymphocytes requires occludin [PDF]

Proceedings of the National Academy of Sciences, 2012
γδ intraepithelial lymphocytes (IELs) are located beneath or between adjacent intestinal epithelial cells and are thought to contribute to homeostasis and disease pathogenesis. Using in vivo microscopy to image jejunal mucosa of GFP γδ T-cell transgenic mice, we discovered that γδ IELs migrate actively within the intraepithelial compartment and into ...
Karen L, Edelblum, Le, Shen, Christopher R, Weber, Amanda M, Marchiando, Bryan S, Clay, Yingmin, Wang, Immo, Prinz, Bernard, Malissen, Anne I, Sperling, Jerrold R, Turner   +9 more
openaire   +2 more sources

Human Breast Milk Enhances Intestinal Mucosal Barrier Function and Innate Immunity in a Healthy Pediatric Human Enteroid Model

Frontiers in Cell and Developmental Biology, 2021
Breastfeeding has been associated with long lasting health benefits. Nutrients and bioactive components of human breast milk promote cell growth, immune development, and shield the infant gut from insults and microbial threats. The molecular and cellular
Gaelle Noel, Julie G. In, Julie G. In, Jose M. Lemme-Dumit, Lauren R. DeVine, Robert N. Cole, Anthony L. Guerrerio, James D. Campbell, Olga Kovbasnjuk, Olga Kovbasnjuk, Marcela F. Pasetti   +10 more
doaj   +1 more source

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources

Zonula occludin toxin, a microtubule binding protein

World Journal of Gastroenterology, 2000
AIM:To investigate the interaction of Zot with microtubule.METHODS:Zot affinity column was applied to purify Zot-binding protein(s) from crude intestinal cell lysates. After incubation at room temperature, the column was washed and the proteins bound to the Zot affinity column were eluted by step gradient with NaCl (0.3molcenter dotL(-1) -0.5molcenter ...
Wen-Le, Wang, Rui-Liang, Lu, MariaRosaria, DiPierro, Alessio, Fasano   +3 more
openaire   +2 more sources