Results 51 to 60 of about 55,164 (304)

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources

Improvement of the bladder perfusion curative effect through tight junction protein degradation induced by magnetic temperature-sensitive hydrogels

Frontiers in Bioengineering and Biotechnology, 2022
Postoperative intravesical instillation of chemotherapy is a routine procedure for non-muscular invasive bladder cancer (NMIBC). However, traditional bladder perfusion methods have insufficient exposure time, resulting in unsatisfactory therapeutic ...
Xiaoliang Sun, Xinhong Song, Peng Guo, Dong Zhang, Shishuai Zuo, Kang Leng, Yun Liu, Haiyang Zhang, Haiyang Zhang, Haiyang Zhang   +9 more
doaj   +1 more source

VE-cadherin and claudin-5: it takes two to tango [PDF]

, 2008
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively.
A Taddei, AS Yap, D Hoogeboom, E Dejana, J Gavard, J Rhee, J. Silvio Gutkind, Julie Gavard, MAG Essers, MG Lampugnani, P Carmeliet, R Paul, S Tsukita, S van Wetering, S Weis, T Nitta, VV Orlova, WJ Nelson   +17 more
core   +5 more sources

Connexin-Occludin Chimeras Containing the Zo-Binding Domain of Occludin Localize at Mdck Tight Junctions and Nrk Cell Contacts [PDF]

The Journal of Cell Biology, 1999
Occludin is a transmembrane protein of the tight junction that functions in creating both an intercellular permeability barrier and an intramembrane diffusion barrier. Creation of the barrier requires the precise localization of occludin, and a distinct family of transmembrane proteins called claudins, into continuous linear fibrils visible by freeze ...
L L, Mitic, E E, Schneeberger, A S, Fanning, J M, Anderson   +3 more
openaire   +2 more sources

Caco2/HT-29 In Vitro Cell Co-Culture: Barrier Integrity, Permeability, and Tight Junctions’ Composition During Progressive Passages of Parental Cells

Biology
Epithelial linings are crucial for the maintenance of physiological barriers. The intestinal epithelial barrier (IEB) consists of enterocytes through tight junctions and mucus-secreting cells and can undergo physiological modifications throughout life ...
Elena Donetti, Paola Bendinelli, Margherita Correnti, Elena Gammella, Stefania Recalcati, Anita Ferraretto   +5 more
doaj   +1 more source

Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection

Frontiers in Microbiology, 2022
Clostridioides difficile is a major causative pathogen of nosocomial antibiotic-associated diarrhea and severe colitis. Despite the use of vancomycin and fidaxomicin as standard drugs for the treatment of C.
Yi-Hsin Lai, Tai-Chieh Wu, Bo-Yang Tsai, Yuan-Pin Hung, Yuan-Pin Hung, Yuan-Pin Hung, Hsiao-Ju Lin, Hsiao-Ju Lin, Yau-Sheng Tsai, Yau-Sheng Tsai, Wen-Chien Ko, Wen-Chien Ko, Pei-Jane Tsai, Pei-Jane Tsai, Pei-Jane Tsai, Pei-Jane Tsai   +15 more
doaj   +1 more source

Occludin expression inhibits tumorigenicity and metastasis

The FASEB Journal, 2006
Occludin is the first identified integral protein for tight junction (TJ), and its long C‐terminal domain is considered to have functions in receiving or transmitting cell survival signals. Loss of TJ‐associated molecules such as occludin has been correlated with tumor progression in carcinogenesis: however, the precise molecular mechanisms explaining ...
Makoto Osanai, Nami Nishikiori, Masaki Murata, Hideki Chiba, Takashi Kojima, Norimasa Sawada   +5 more
openaire   +1 more source

Role of Stress on Driving the Intestinal Paracellular Permeability

Current Issues in Molecular Biology, 2023
The gut epithelium is a polarized monolayer that exhibits apical and basolateral membrane surfaces. Monolayer cell components are joined side by side via protein complexes known as tight junction proteins (TJPs), expressed at the most apical extreme of ...
Daniel Efrain Molotla-Torres, Fabiola Guzmán-Mejía, Marycarmen Godínez-Victoria, Maria Elisa Drago-Serrano   +3 more
doaj   +1 more source

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]

, 2018
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro, García Domínguez, Irene, García Revilla, Juan, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Santiago Pavón, Martiniano, Venero Recio, José Luis, Veselá, Karolina   +7 more
core   +3 more sources

Impaired Intestinal Permeability of Tricellular Tight Junctions in Patients with Irritable Bowel Syndrome with Mixed Bowel Habits (IBS-M)

Cells, 2023
Background: The underlying pathophysiology of irritable bowel syndrome (IBS) is still unclear. Our aim was to investigate the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type IBS (IBS-M).
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Jörg-Dieter Schulzke, Roland Bücker   +7 more
doaj   +1 more source