Results 81 to 90 of about 55,164 (304)

Role of Homeobox A1 in Airway Epithelial Generation from Human Airway Basal Cells

Cells
Airway basal cells from chronic obstructive pulmonary disease patients show a reduction in HOXA1 expression and generate an abnormal airway epithelium.
Mohsen Tabasi, Nathaniel Chen, Umadevi Sajjan   +2 more
doaj   +1 more source

Tight Junctions Go Viral!

Viruses, 2015
Tight junctions (TJs) are highly specialized membrane domains involved in many important cellular processes such as the regulation of the passage of ions and macromolecules across the paracellular space and the establishment of cell polarity in ...
Jesús M. Torres-Flores, Carlos F. Arias
doaj   +1 more source

Impact of dietary manganese on intestinal barrier and inflammatory response in broilers challenged with Salmonella Typhimurium [PDF]

, 2020
Growing concern for public health and food safety has prompted a special interest in developing nutritional strategies for removing waterborne and foodborne pathogens, including Salmonella.
Bai, Jie, Bai, Shiping, Ding, Xuemei, Michiels, Joris, Pan, Shuqin, Peng, Huanwei, Su, Zhuowei, Wang, Jianping, Xuan, Yue, Zeng, Qiufeng, Zhang, Huaiyong, Zhang, Keying   +11 more
core   +2 more sources

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Collagen prolyl 4-hydroxylase subunit α member-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via reduced expression of occludin

Acta Biochimica et Biophysica Sinica
There are three isoforms of human collagen prolyl 4-hydroxylases (C-P4Hs), each of which has been reported to play an important role in regulating the progression of a variety of human cancers. By analyzing TGCA
Xu Miao, Shi Run, Yang Jie, Chen Heng, Liu Shihua, Yu Shupei, Li Sasa, He Wenqiang, Sy Man-Sun, Lu Mingjian, Zhang Huixia, Li Chaoyang   +11 more
doaj   +1 more source

Intestinal Barrier Function in Gluten-Related Disorders [PDF]

, 2019
Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the contact of the gastrointestinal mucosa with components of wheat and other ...
Branchi, Federica, Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Moerkens, Renée, Schumann, Michael, Withoff, Sebo   +6 more
core   +2 more sources

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice

Journal of Lipid Research, 2010
Fructose intake is being discussed as a key dietary factor in the development of nonalcoholic fatty liver disease (NAFLD). Bile acids have been shown to modulate energy metabolism. We tested the effects of bile acids on fructose-induced hepatic steatosis.
Valentina Volynets, Astrid Spruss, Giridhar Kanuri, Sabine Wagnerberger, Stephan C. Bischoff, Ina Bergheim   +5 more
doaj   +1 more source

Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease [PDF]

, 2018
Huntington's disease (HD) is themost common neurodegenerative disorder for which no effective cure is yet available. Although several agents have been identified to provide benefits so far, the number of therapeutic options remains limited with only ...
Amico, Enrico, Buttari, Fabio, Capocci, Luca, Castaldo, Salvatore, Di Pardo, Alba, Giovannelli, Alfredo, Madonna, Michele, Maglione, Vittorio, Marracino, Federico, Pepe, Giuseppe, van Bergeijk, Jeroen, van der Kam, Elizabeth   +11 more
core   +1 more source

Occludin is overexpressed in Alzheimer's disease and vascular dementia [PDF]

Journal of Cellular and Molecular Medicine, 2007
AbstractThe tight junctions (TJs) are key players in the control of blood‐brain barrier (BBB) properties, the most complex TJs in the vascular system being found in the endothelial cells of brain capillaries. One of the main TJs proteins is occludin, which anchors plasma membranes of neighbour cells and is present in large amounts in the brain ...
Romanitan, Mihaela Oana, Popescu, Bogdan O, Winblad, Bengt, Bajenaru, Ovidiu Alexandru, Bogdanovic, Nenad   +4 more
openaire   +2 more sources