Celecoxib Blocks Vasculogenic Mimicry via an Off-Target Effect to Radiosensitize Lung Cancer Cells: An Experimental Study [PDF]
Frontiers in Oncology, 2021 The resistance to radiotherapy in lung cancer can be attributed to vasculogenic mimicry (VM) to some extent. Celecoxib (CXB), a selective inhibitor of cyclooxygenase-2 (COX-2), is reported as a radiosensitizer in non-small cell lung cancer (NSCLC ...
Kai Niu +6 more
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An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA [PDF]
Molecular Therapy: Nucleic AcidsWe developed siRMSD, a predictive parameter for off-target effects induced by chemical modifications, to optimize siRNA therapeutics. In RNA interference, small interfering RNA (siRNA) suppresses gene function by degrading mRNA with perfect sequence ...
Seongjin An +5 more
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Cytosine base editing systems with minimized off-target effect and molecular size [PDF]
Nature Communications, 2022 Base editing is promising for gene therapy, but in vivo delivery has been limiting. Here the authors perform structure-based rational engineering of the cytosine base editing system Target-AID to minimise off-target effects and decrease its size.
Ang Li +5 more
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Reduced off-target effect of NG-BE4max by using NG-HiFi system [PDF]
Molecular Therapy: Nucleic Acids, 2021 Recently, a rationally engineered SpCas9 variant (SpCas9-NG) that can recognize a minimal NG protospacer adjacent motif (PAM) was reported to expand the targeting scope in genome editing.
Huanhuan Shan +8 more
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Recent Advancements in Reducing the Off-Target Effect of CRISPR-Cas9 Genome Editing [PDF]
Biologics: Targets & TherapyMisganaw Asmamaw Mengstie,1 Muluken Teshome Azezew,2 Tadesse Asmamaw Dejenie,3 Assefa Agegnehu Teshome,4 Fitalew Tadele Admasu,1 Awgichew Behaile Teklemariam,1 Anemut Tilahun Mulu,1 Melaku Mekonnen Agidew,1 Dagnew Getnet Adugna,5 Habtamu Geremew,6 ...
Asmamaw Mengstie M +10 more
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CRISPR-M: Predicting sgRNA off-target effect using a multi-view deep learning network. [PDF]
PLoS Computational BiologyUsing the CRISPR-Cas9 system to perform base substitutions at the target site is a typical technique for genome editing with the potential for applications in gene therapy and agricultural productivity.
Jialiang Sun, Jun Guo, Jian Liu
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Procoagulant off-target effect of the direct oral anticoagulant reversal agent Andexanet alfa [PDF]
Blood Vessels, Thrombosis & Hemostasis: Patients with hemorrhage after treatment with direct oral anticoagulants (DOACs) are saved from hematoma expansion by administration of Andexanet alfa, a modified factor Xa analog.
Ischa M. S. Hoornstra +9 more
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Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics [PDF]
Frontiers in Genetics, 2013 Kumiko eUi-Tei, Kumiko eUi-Tei
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A Novel Anti-Cancer Therapy: CRISPR/Cas9 Gene Editing
Frontiers in Pharmacology, 2022 Cancer becomes one of the main causes of human deaths in the world due to the high incidence and mortality rate and produces serious economic burdens. With more and more attention is paid on cancer, its therapies are getting more of a concern.
Xin-Zhu Chen +11 more
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Reduction in PCSK9 levels induced by anacetrapib: an off-target effect?1 [PDF]
Journal of Lipid Research, 2015 Philip J. Barter +2 more
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