Results 31 to 40 of about 2,759,679 (292)
Development of therapeutic-grade small interfering RNAs by chemical engineering
Frontiers in Genetics, 2012 Recent successes in clinical trials have provided important proof of concept that small interfering RNAs indeed constitute a new promising class of therapeutics.
Jesper Bertram Bramsen, Jørgen eKjems
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BMC Medical Informatics and Decision Making, 2020 Background It is of utmost importance to investigate novel therapies for cancer, as it is a major cause of death. In recent years, immunotherapies, especially those against immune checkpoints, have been developed and brought significant improvement in ...
Yuyu Zheng +4 more
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On Polarization Of The Beam Extracted With The Bent Crystal [PDF]
, 2007 Particles scattered off the nuclear target acquire a polarization if the nuclei have a non zero analyzing power. This effect is enhanced when particles traverse a bent crystal.
Ukhanov, M. N.
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Small-x Parton Distributions of Large Hadronic Targets [PDF]
, 1998 A simple and intuitive calculation, based on the semiclassical approximation, demonstrates how the large size of a hadronic target introduces a new perturbative scale into the process of small-x deep inelastic scattering.
A. Hebecker +12 more
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The current landscape of microRNAs (miRNAs) in bacterial pneumonia: opportunities and challenges
Cellular & Molecular Biology Letters, 2022 MicroRNAs (miRNAs), which were initially discovered in Caenorhabditis elegans, can regulate gene expression by recognizing cognate sequences and interfering with the transcriptional or translational machinery.
Fan Zhang, Yunxin Zhou, Junying Ding
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Molecular Therapy: Nucleic Acids, 2023 Small interfering RNA (siRNA) and short hairpin RNA (shRNA) are widely used as RNA interference (RNAi) reagents. Recently, truncated shRNAs that trigger RNAi in a Dicer-independent manner have been developed.
Atsushi Shibata +6 more
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Chemical Modifications Rescue Off-Target Effects of RNAi [PDF]
ACS Chemical Biology, 2006 RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.
Ola, Snøve, John J, Rossi
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Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9. [PDF]
, 2020 CRISPR-Cas9 is the forefront technology for editing the genome. In this system, the Cas9 protein is programmed with guide RNAs to process DNA sequences that match the guide RNA forming an RNA:DNA hybrid structure.
Hsu, Rohaine V +5 more
core
Off-target effects in CRISPR/Cas9 gene editing
Frontiers in Bioengineering and Biotechnology, 2023 Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene editing has become efficient, convenient and programmable, leading to promising translational studies and clinical trials for both ...
Congting Guo +7 more
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Serotonin-releasing agents with reduced off-target effects
Molecular Psychiatry, 2022 Abstract Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g. social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studies established the potential of drugs inducing the release of 5-HT via the 5-HT-transporter ...
Felix P Mayer +20 more
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