Results 41 to 50 of about 2,759,679 (292)

Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth. [PDF]

, 2015
Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma.
Agostinelli, C, Benvenuti, P, Casellato, A, Fuligni, F, Mandato, E, Piazza, Francesco, Pileri, Sa, Pizzi, Marco, Rugge, Massimo, Semenzato, Gianpietro Carlo   +9 more
core   +1 more source

Wavefunction corrections and off-forward gluon distributions in diffractive J/psi electroproduction

, 1996
Diffractive production of J/Psi particles by virtual photons on a proton target is studied with a view towards understanding two important corrections to the leading order result.
Hoodbhoy, Pervez
core   +2 more sources

Initial State Dependence of the Breakup of Weakly Bound Carbon Isotopes [PDF]

, 1999
The one-neutron nuclear breakup from the Carbon isotopes $^{19}$C and $^{17}$C, is calculated as an example of application of the theory of transfer to the continuum reactions in the formulation which includes spin coupling.
A. A. Korsheninnikov, A. Bonaccorso, A. Bonaccorso, A. Bonaccorso, A. Bonaccorso, A. Bonaccorso, A. Bonaccorso, A. Bonaccorso, A. Bonaccorso, A. Bonaccorso, A. Navin, Angela Bonaccorso, C. A. Bertulani, C. Mahaux, D. Bazin, D. Bazin, D. Ridikas, D. Ridikas, E. Garrido, E. K. Barburton, F. Barranco, F. M. Marques, F. Negoita, G. Baur, G. F. Bertsch, H. Esbensen, H. Esbensen, H. Hashim, H. Sagawa, I. Pecina, I. Tanihata, J. A. Christley, J. A. Nolen, J. A. Tostevin, J. A. Tostevin, J. H. Dave, J. K. Kelley, K. Hencken, L. Lo Monaco, L. V. Chulkov, L. V. Chulkov, M. G. Saint-Laurent, M. H. Smedberg, N. A. Orr, P. G. Hansen, P. G. Hansen, R. Anne, R. Shyam, R. W. Finlay, Ren Zhongzhou, T. Baumann, T. Nakamura, W. Schwab, W. Von Oertzen, Y. Ogawa, Y. Ogawa   +55 more
core   +2 more sources

Structure-Guided Control of siRNA Off-Target Effects [PDF]

Journal of the American Chemical Society, 2016
Short interfering RNAs (siRNAs) are promising therapeutics that make use of the RNA interference (RNAi) pathway, but liabilities arising from the native RNA structure necessitate chemical modification for drug development. Advances in the structural characterization of components of the human RNAi pathway have enabled structure-guided optimization of ...
Suter, Scott R, Sheu-Gruttadauria, Jessica, Schirle, Nicole T, Valenzuela, Rachel, Ball-Jones, Alexi A, Onizuka, Kazumitsu, MacRae, Ian J, Beal, Peter A   +7 more
openaire   +4 more sources

Oncogenesis: An “Off-Target” Effect of Radiofrequency Ablation [PDF]

Radiology, 2015
To compare hepatocellular carcinoma (HCC) development after radiofrequency (RF) ablation, partial surgical hepatectomy, and a sham operation and to inhibit HCC recurrence after RF ablation in a mouse model of spontaneously forming HCC in the setting of chronic inflammation (ie, the MDR2 knockout model).Animal experiments were performed according to an ...
Nir, Rozenblum, Evelyne, Zeira, Viviana, Scaiewicz, Baruch, Bulvik, Svetlana, Gourevitch, Hagit, Yotvat, Eithan, Galun, S Nahum, Goldberg   +7 more
openaire   +2 more sources

Collins effect and single spin azimuthal asymmetries in the HERMES and COMPASS experiments

, 2003
Predictions are made for single spin azimuthal asymmetries due to the Collins effect in pion production from semi-inclusive deeply inelastic scattering off transversely and longitudinally polarized targets for the HERMES and COMPASS experiments.
37, 56, A. V. Efremov, Anselmino, Anselmino, Avakian, Bacchetta, Balla, Belitsky, Boer, Boer, Boer, Brodsky, Brodsky, Collaboration], Collaboration], Collaboration], Collaboration], Collaboration], Collaboration], Collaboration], Collaboration], Collins, Collins, Collins, Diakonov, Diakonov, Diakonov, Dressler, Efremov, Efremov, Efremov, Efremov, Efremov, Efremov, Efremov, Gamberg, Glück, K. Goeke, Korotkov, Ma, Makins, Martin, Mulders, P. Schweitzer, Pobylitsa, Ralston, Sanctis, Schäfer, Sivers, Soffer, Umnikov   +51 more
core   +3 more sources

High-Throughput Screening to Identify Novel Compounds Affecting the Genome Editing Efficiency of CRISPR System

Molecules
Genome editing is a promising therapeutic strategy for genetic disorders by modifying the genome precisely, especially the CRISPR/Cas9 system. However, a major limitation of CRISPR/Cas9 in gene therapy is the biosafety issues caused by off-target effects.
Jiasong Chang, Xiulong Yang, Tong Zhang, Hao Sun, Hongying Cheng, Zhangrong Jia, Yiying Li, Sanyuan Ma, Teng Sun, Jimin Cao   +9 more
doaj   +1 more source

Off-Target Cannabinoid Effects Mediated by GPR55 [PDF]

Pharmacology, 2012
Given the vast therapeutic potential of the endocannabinoid system, the revelation of a novel cannabinoid-sensitive target was treated with great excitement. The orphan G-protein coupled receptor 55 (GPR55) was initially touted as a novel cannabinoid target in early industrial patent literature.
openaire   +3 more sources

Translation of CRISPR Genome Surgery to the Bedside for Retinal Diseases

Frontiers in Cell and Developmental Biology, 2018
In recent years, there has been accelerated growth of clustered regularly interspaced short palindromic repeats (CRISPR) genome surgery techniques. Genome surgery holds promise for diseases for which a cure currently does not exist.
Christine L. Xu, Christine L. Xu, Galaxy Y. Cho, Galaxy Y. Cho, Galaxy Y. Cho, Jesse D. Sengillo, Jesse D. Sengillo, Jesse D. Sengillo, Karen S. Park, Karen S. Park, Vinit B. Mahajan, Vinit B. Mahajan, Stephen H. Tsang, Stephen H. Tsang, Stephen H. Tsang, Stephen H. Tsang   +15 more
doaj   +1 more source

Using gene transfer to circumvent off-target effects [PDF]

Gene Therapy, 2008
Many recombinant growth factors have failed in clinical trials due to off-target effects. We describe a method for circumventing off-target effects that involves equipping cells with a conditionally active signaling protein that can be specifically activated by an exogenously administered synthetic ligand.
C P, Miller, C A, Blau
openaire   +2 more sources