Results 51 to 60 of about 2,759,679 (292)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The HIT network was established in 2000 to create a population‐based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Stefan Rutkowski +59 more
wiley +1 more source
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. [PDF]
, 2019 BackgroundRewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions.
Bates, Sofie L +8 more
core +2 more sources
5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumourigenesis
Frontiers in Pharmacology, 2010 Leukotrienes (LTs) constitute a group of bioactive lipids generated by the 5-lipoxygenase (5-LO) pathway. An increasing body of evidence supports an acute role for 5-LO products already during the earliest stages of pancreatic, prostate and colorectal ...
Dieter eSteinhilber +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Asymptomatic infection poses a significant risk for children undergoing hematopoietic stem cell transplantation (HSCT). Pre‐transplant surveillance computed tomography (CT) is commonly used to identify occult infection, though its diagnostic yield remains uncertain.
Tyler Obermark +9 more
wiley +1 more source
Radiation Pressure Acceleration: the factors limiting maximum attainable ion energy
, 2016 Radiation pressure acceleration (RPA) is a highly efficient mechanism of laser-driven ion acceleration, with with near complete transfer of the laser energy to the ions in the relativistic regime.
Bulanov, S. S. +7 more
core +1 more source
Deviation from target debt ratio, cash flow imbalance and capital structure adjustment [PDF]
تحقیقات مالی, 2016 Most of capital structure researches have been conducted on the two dominant theories: trade-off and pecking order. Based on the trade-off theory, every firm has a target capital structure, while pecking order theory assumes that there is no target ...
Maryam Davallou, Alireza Rezaeian
doaj +1 more source
Intriguing Off-Target Effects of Ezetimibe
Journal of the American College of Cardiology, 2015 Tsujita et al. [(1)][1] report patients randomized to atorvastatin + ezetimibe therapy experienced a greater reduction in the percentage of atheroma volume than those randomized to atorvastatin, and it may be due to the lower mean low-density lipoprotein cholesterol achieved.
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia +7 more
wiley +1 more source
Non-adiabatic corrections to elastic scattering of halo nuclei
, 2002 We derive the formalism for the leading order corrections to the adiabatic approximation to the scattering of composite projectiles. Assuming a two-body projectile of core plus loosely-bound valence particle and a model (the core recoil model) in which ...
C.V. Sukumar +20 more
core +1 more source
Off-target effects of siRNA specific for GFP [PDF]
BMC Molecular Biology, 2008 Gene knock down by RNAi is a highly effective approach to silence gene expression in experimental as well as therapeutic settings. However, this widely used methodology entails serious pitfalls, especially concerning specificity of the RNAi molecules.We tested the most widely used control siRNA directed against GFP for off-target effects and found that
Tschuch, Cordula +8 more
openaire +2 more sources