Results 81 to 90 of about 2,759,679 (292)

On-target and Off-target-based Toxicologic Effects [PDF]

Toxicologic Pathology, 2012
Adverse toxicologic effects are categorized as chemical-based, on-target, or off-target effects. Chemical-based toxicity is defined as toxicity that is related to the physicochemical characteristics of a compound and its effects on cellular organelles, membranes, and/or metabolic pathways.
openaire   +2 more sources

Molecular Methods for Rare Hemoglobinopathy Cases: First Brazilian Report of Pediatric Siblings with Hb O‐Arab and Alpha‐Thalassemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk, Amanda Cristina Meneguetti Berti, Bárbara Braga Vieira Marques, Victoria Simões Bernardo, Flaviene Felix Torres, Ingrid Souza Dias, Vanessa da Silveira Ramos de Castro, Gabriela Alves Bernardino, Danilo Grünig Humberto da Silva, Edis Belini‐Júnior   +9 more
wiley   +1 more source

PREDICTION OF OFF-TARGET DRUG EFFECTS THROUGH DATA FUSION [PDF]

Biocomputing 2014, 2013
We present a probabilistic data fusion framework that combines multiple computational approaches for drawing relationships between drugs and targets. The approach has special relevance to identifying surprising unintended biological targets of drugs. Comparisons between molecules are made based on 2D topological structural considerations, based on 3D ...
Altman, Russ B, Dunker, A Keith, Hunter, Lawrence, Murray, Tiffany A, Klein, Teri E, Ritchie, Marylyn D, YERA, EMMANUEL R, CLEVES, ANN E, JAIN, AJAY N   +8 more
openaire   +4 more sources

Prime Editing Exhibits Limited Genome-Wide Off-Target Effects in Cellular and Embryonic Gene Editing

Cells
Prime editing (PE) is a precise genome-editing technology that avoids double-strand breaks, holding great promise for clinical and agricultural applications.
Jitan Zheng, Mingdi Wu, Xueyan Wang, Zhenrui Zuo, Chikai Zhou, Erwei Zuo, Yangqing Lu   +6 more
doaj   +1 more source

Comprehensive computational analysis of epigenetic descriptors affecting CRISPR-Cas9 off-target activity

BMC Genomics, 2022
Background A common issue in CRISPR-Cas9 genome editing is off-target activity, which prevents the widespread use of CRISPR-Cas9 in medical applications.
Jeffrey K. Mak, Florian Störtz, Peter Minary   +2 more
doaj   +1 more source

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Off-target effects by siRNA can induce toxic phenotype [PDF]

RNA, 2006
Although recent microarray studies have provided evidence of RNA interference (RNAi)-mediated off-target gene modulation, little is known about whether these changes induce observable phenotypic outcomes. Here we show that a fraction of randomly selected small inhibitory RNAs (siRNAs) can induce changes in cell viability in a target-independent fashion.
Yuriy, Fedorov, Emily M, Anderson, Amanda, Birmingham, Angela, Reynolds, Jon, Karpilow, Kathryn, Robinson, Devin, Leake, William S, Marshall, Anastasia, Khvorova   +8 more
openaire   +2 more sources

Predicting the role of geotechnical parameters on the output from shallow buried explosives [PDF]

, 2016
Experiments have been conducted to quantify the effect the geotechnical conditions surrounding a buried charge have on the resulting output. From the results obtained the critical importance of moisture content in governing the magnitude of impulse ...
Clarke, S.D., Elgy, I., Fay, S.D., Livesey, R., Reay, J.J., Rigby, S.E., Tyas, A., Warren, J.A.   +7 more
core   +1 more source

CRISPR/Cas9 from bench to bedside: what clinicians need to know before application?

Military Medical Research, 2020
In October 2020, Dr. Emmanuelle Charpentier and Dr. Jennifer Doudna won the Nobel Prize in Chemistry for their pioneering work in precise genome editing using the CRISPR technology.
Zi-Qing Li, Chao-Hong Li
doaj   +1 more source

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source