Results 1 to 10 of about 26,552 (115)

Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells [PDF]

Molecules, 2023
Myelin repair, which is known as remyelination, is critical to the treatment of neurodegenerative diseases, and myelination depends on not only the differentiation of oligodendrocyte precursor cells toward oligodendrocytes but also the renewal of ...
Feifei Yang, Han Wen, Siqi Ma, Qi Chang, Ruile Pan, Xinmin Liu, Yonghong Liao   +6 more
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Oligodendrocyte precursor cells facilitate neuronal lysosome release [PDF]

Nature Communications
Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner.
Li-Pao Fang, Ching-Hsin Lin, Yasser Medlej, Renping Zhao, Hsin-Fang Chang, Qilin Guo, Zhonghao Wu, Yixun Su, Na Zhao, Davide Gobbo, Amanda Wyatt, Vanessa Wahl, Frederic Fiore, Szu-Min Tu, Ulrich Boehm, Wenhui Huang, Shan Bian, Amit Agarwal, Marcel A. Lauterbach, Chenju Yi, Jianqin Niu, Anja Scheller, Frank Kirchhoff, Xianshu Bai   +23 more
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Unlocking the Potential: immune functions of oligodendrocyte precursor cells [PDF]

Frontiers in Immunology
Oligodendrocyte precursor cells (OPCs) have long been regarded as progenitors of oligodendrocytes, yet recent advances have illuminated their multifaceted nature including their emerging immune functions.
Amr Haroon, Harsha Seerapu, Li-Pao Fang, Li-Pao Fang, Jakob Heinrich Weß, Xianshu Bai, Xianshu Bai   +6 more
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Implications of Olig2 silencing in oligodendrocyte precursor cells [PDF]

Neural Regeneration Research, 2023
Li-Pao Fang, Xianshu Bai
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Human Wharton’s Jelly Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Drive Oligodendroglial Maturation by Restraining MAPK/ERK and Notch Signaling Pathways

Frontiers in Cell and Developmental Biology, 2021
Peripartum cerebral hypoxia and ischemia, and intrauterine infection and inflammation, are detrimental for the precursor cells of the myelin-forming oligodendrocytes in the prematurely newborn, potentially leading to white matter injury (WMI) with long ...
Marianne S. Joerger-Messerli, Marianne S. Joerger-Messerli, Gierin Thomi, Gierin Thomi, Gierin Thomi, Valérie Haesler, Valérie Haesler, Irene Keller, Irene Keller, Patricia Renz, Patricia Renz, Patricia Renz, Daniel V. Surbek, Daniel V. Surbek, Andreina Schoeberlein, Andreina Schoeberlein   +15 more
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Hepatoma Derived Growth Factor Enhances Oligodendrocyte Genesis from Subventricular Zone Precursor Cells

ASN Neuro, 2022
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), perform vital functions in neural protection and communication, as well as cognition.
Yutong Li, Nicole Leanne Dittmann, Adrianne Eve Scovil Watson, Monique Marylin Alves de Almeida, Tim Footz, Anastassia Voronova   +5 more
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DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes. [PDF]

PLoS ONE, 2014
Disrupted-in-schizophrenia 1 (DISC1) is a gene disrupted by a translocation, t(1;11) (q42.1;q14.3), that segregates with major psychiatric disorders, including schizophrenia, recurrent major depression and bipolar affective disorder, in a Scottish family.
Tsuyoshi Hattori, Shoko Shimizu, Yoshihisa Koyama, Hisayo Emoto, Yuji Matsumoto, Natsuko Kumamoto, Kohei Yamada, Hironori Takamura, Shinsuke Matsuzaki, Taiichi Katayama, Masaya Tohyama, Akira Ito   +11 more
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Diabetes Mellitus-Related Neurobehavioral Deficits in Mice Are Associated With Oligodendrocyte Precursor Cell Dysfunction

Frontiers in Aging Neuroscience, 2022
Recent clinical studies demonstrated an increase of the incidence of neurobehavioral disorders in patients with diabetes mellitus. Studies also found an association between severity of diabetes mellitus and the progression of white matter hyperintensity ...
Li-Ping Wang, Li-Ping Wang, Jieli Geng, Chang Liu, Yuyang Wang, Zhijun Zhang, Guo-Yuan Yang   +6 more
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Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination

eLife, 2023
In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced ...
Lin Pan, Amelia Trimarco, Alice J Zhang, Ko Fujimori, Yoshihiro Urade, Lu O Sun, Carla Taveggia, Ye Zhang   +7 more
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Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment

Acta Neuropathologica Communications, 2023
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the development of white matter lesions.
Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J. Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F. A. Jansen, Walter H. Backes, Robert J. van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W. Matthijs Blankesteijn, Sébastien Foulquier   +16 more
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