Oligodendrocyte precursor cells synthesize neuromodulatory factors.
PLoS ONE, 2015 NG2 protein-expressing oligodendrocyte progenitor cells (OPC) are a persisting and major glial cell population in the adult mammalian brain. Direct synaptic innervation of OPC by neurons throughout the brain together with their ability to sense neuronal ...
Dominik Sakry +3 more
doaj +5 more sources
Migration Assays for Oligodendrocyte Precursor Cells
, 2003 In the developing central nervous system (CNS), oligodendrocyte precursor cells (OPCs) originate in discreet regions, which may be at a significant distance from their final position. These cells must, therefore, undergo extensive migration in order to reach this final destination (1).
Frost, Emma E. +2 more
openaire +4 more sources
Caffeoylquinic acid enhances proliferation of oligodendrocyte precursor cells
Translational Neuroscience, 2017 This report evaluates the protective effect of caffeoylquinic acid (CA) injury to oligodendrocyte precursor cells (OPCs) by promoting the formation of oligodendrocytes.
Yanqin Ying +3 more
doaj +3 more sources
3D morphological reconstruction of oligodendrocyte precursor cells [PDF]
, 2015 Reconstruction of mouse cerebellar oligodendrocyte precursor cells. Cells in cultured brain slices were labeled using a recombinant viral vector encoding membrane targeted GFP.
Fulton, Daniel
core +8 more sources
Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12
NeuroReport, 2006 Migration, proliferation, and differentiation of oligodendrocyte precursor cells are essential for the assembly of myelin in the central nervous system. Knowledge on the regulation of these precursor cells is therefore of great importance for the understanding of developmental myelination and remyelination in demyelinating diseases.
Maysami, Samaneh +6 more
openaire +4 more sources
Oligodendrocyte precursor cells: the multitaskers in the brain. [PDF]
Pflugers Arch, 2023 Abstract In the central nervous system, oligodendrocyte precursor cells (OPCs) are recognized as the progenitors responsible for the generation of oligodendrocytes, which play a critical role in myelination. Extensive research has shed light on the mechanisms underlying OPC proliferation and differentiation
Fang LP, Bai X.
europepmc +3 more sources
Clinical application of oligodendrocyte precursor cells for cell-based therapy [PDF]
Brain Circulation, 2016 Oligodendrocyte precursor cells (OPCs), which give rise to mature oligodendrocytes (OLs), play important roles in maintaining white matter function. Even during the adulthood period, OPCs comprise roughly 5% of all cells in the forebrain and retain a ...
Naohiro Egawa +4 more
doaj +3 more sources
Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain [PDF]
, 2021 Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over
Vidorreta Ballesteros, Lucía +31 more
core +1 more source
Features, Fates, and Functions of Oligodendrocyte Precursor Cells. [PDF]
Cold Spring Harb Perspect Biol, 2023 Oligodendrocyte precursor cells (OPCs) are a central nervous system resident population of glia with a distinct molecular identity and an ever-increasing list of functions. OPCs generate oligodendrocytes throughout development and across the life span in most regions of the brain and spinal cord.
Hill RA, Nishiyama A, Hughes EG.
europepmc +3 more sources
Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells. [PDF]
, 2002 Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Pichkhadze, B. +4 more
core +7 more sources