MHC class I and II expression and induction in oligodendrocytes varies with age [PDF]
Scientific ReportsOligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Riley B. Catenacci +4 more
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Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication [PDF]
Nature CommunicationsEmerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier +6 more
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Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation [PDF]
Genome Biology, 2022 Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human brain.
Yangping Li +6 more
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Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]
iScienceSummary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson +3 more
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A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome [PDF]
Acta Neuropathologica CommunicationsWolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene.
K. Ahuja +27 more
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Frontiers in Neuroscience, 2022 Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons in their mature stages. Dysfunction in this lineage occurs when early stage OPCs are not able to differentiate to replace dying Mature Myelinating Oligodendrocytes ...
Miguel M. Madeira +7 more
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Chromatin remodelers in oligodendroglia [PDF]
Glia, 2020 AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras +3 more
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Oligodendroglial Heterogeneity in Neuropsychiatric Disease
Life, 2021 Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and ...
Sunniva M. K. Bøstrand, Anna Williams
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Frontiers in Neuroscience, 2021 Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial dysfunction and/or disruption of white matter integrity are found in the brains of patients with schizophrenia.
Xianjun Chen +8 more
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Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes [PDF]
Diabetes & Metabolism Journal, 2022 As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis.
Xiaolong Li +3 more
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