A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome [PDF]
Acta Neuropathologica CommunicationsWolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene.
K. Ahuja +27 more
doaj +4 more sources
Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation [PDF]
Genome Biology, 2022 Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human brain.
Yangping Li +6 more
doaj +2 more sources
MHC class I and II expression and induction in oligodendrocytes varies with age [PDF]
Scientific ReportsOligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Riley B. Catenacci +4 more
doaj +2 more sources
The oligodendroglia cytoskeleton in health and disease [PDF]
Journal of Neuroscience Research, 2000 Oligodendrocytes have a high rate of synthetic activity and produce vast amounts of myelin. The membrane production requires specific sorting and transport processes and structural support. In culture, oligodendrocytes extend flat membranous sheets containing an extensive cytoskeletal network of microtubules (MTs) and microfilaments (MFs).
Christiane Richter‐Landsberg
openalex +7 more sources
Degeneração mucóide da oligodendroglia em um caso de enfermidade do grupo Wilson [PDF]
Arquivos de Neuro-Psiquiatria, 1944 Recordam-se, no presente trabalho, as alterações da oligodendroglia em particular a degeneração mucóide. Relata-se sinteticamente um caso do grupo Wilson - espasmo de torção - em que havia degeneração mucóide da oligodendroglia predominantemente na ...
A. Austregésilo Filho
doaj +2 more sources
Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]
iScienceSummary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson +3 more
doaj +2 more sources
Altered oligodendroglia and astroglia in chronic traumatic encephalopathy [PDF]
Acta Neuropathologica, 2020 Abstract Chronic traumatic encephalopathy (CTE) is a progressive tauopathy found in contact sport athletes, military veterans, and others exposed to repetitive head impacts (RHI)1–6. White matter atrophy and axonal loss have been reported in CTE but have not been characterized on a molecular or cellular level2,7,8.
K. Blake Chancellor +8 more
openalex +7 more sources
Journal of Lipid Research, 1977 Plasmalogenase (EC 3.3.2.-, 1-alk-1′-enyl-2-acyl-sn-glycero-3-phosphorylethanolamine aldehydrogendrolase) activities were assayed with the plasmalogens in dispersed myelin as the substrate.
R V Dorman, A D Toews, L A Horrocks
doaj +2 more sources
Oligodendroglia vulnerability in the human dorsal striatum in Parkinson’s disease
Acta NeuropathologicaAbstract Oligodendroglia are the responsible cells for myelination in the central nervous system and their involvement in Parkinson’s disease (PD) is poorly understood. We performed sn-RNA-seq and image-based spatial transcriptomics of human caudate nucleus and putamen (dorsal striatum) from PD and control brain donors to elucidate the ...
Juan M. Barba-Reyes +10 more
openalex +4 more sources
Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1). [PDF]
Acta Neuropathol CommunAghoghovwia BE +8 more
europepmc +3 more sources