A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome. [PDF]
Acta Neuropathol CommunWolfram syndrome (WS) is a rare childhood disease characterized by diabetes mellitus, diabetes insipidus, blindness, deafness, neurodegeneration and eventually early death, due to autosomal recessive mutations in the WFS1 (and WFS2) gene.
Ahuja K +27 more
europepmc +5 more sources
Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation [PDF]
Genome Biology, 2022 Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human brain.
Yangping Li +6 more
doaj +3 more sources
MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis. [PDF]
Elife, 2023 Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined.
Harrington EP +8 more
europepmc +3 more sources
Oligodendroglia are emerging players in several forms of learning and memory [PDF]
Communications Biology, 2022 A Perspective highlights current evidence that supports oligodendrocytes and their progenitors’ involvement in cognition and proposes that our understanding of learning and memory can be expanded beyond the classic view of synaptic plasticity to a system-
Maxime Munyeshyaka, R. Douglas Fields
doaj +3 more sources
MHC class I and II expression and induction in oligodendrocytes varies with age. [PDF]
Sci RepOligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Catenacci RB +4 more
europepmc +2 more sources
Degeneração mucóide da oligodendroglia em um caso de enfermidade do grupo Wilson [PDF]
Arquivos de Neuro-Psiquiatria, 1944 Recordam-se, no presente trabalho, as alterações da oligodendroglia em particular a degeneração mucóide. Relata-se sinteticamente um caso do grupo Wilson - espasmo de torção - em que havia degeneração mucóide da oligodendroglia predominantemente na ...
A. Austregésilo Filho
doaj +2 more sources
Diagnostic Insighhts Into JC Virus-Infected Glial Cells: Intraoperative Cytopathological Analysis of Dot-Shaped Inclusions Associated With PML-NBs. [PDF]
CytopathologyThis is the first case report describing the diagnostic value of dot‐shaped inclusions associated with promyelocytic leukaemia nuclear bodies (PML‐NBs) to define JC virus–infected glial cells in an intraoperative cytopathological diagnosis for progressive multifocal leukoencephalopathy (PML).
Ujihira N, Doi H, Shishido-Hara Y.
europepmc +2 more sources
Mosaic subventricular origins of forebrain oligodendroglia [PDF]
Frontiers in Neuroscience, 2016 In the perinatal as well as the adult CNS, the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates neurons and oligodendrocytes (OLs), the myelin forming cells of the CNS.
Kasum eAzim +2 more
doaj +3 more sources
Journal of Lipid Research, 1977 Plasmalogenase (EC 3.3.2.-, 1-alk-1′-enyl-2-acyl-sn-glycero-3-phosphorylethanolamine aldehydrogendrolase) activities were assayed with the plasmalogens in dispersed myelin as the substrate.
R V Dorman, A D Toews, L A Horrocks
doaj +2 more sources
Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury. [PDF]
J Neuropathol Exp NeurolRuscher K +7 more
europepmc +2 more sources