Results 1 to 10 of about 15,108 (198)

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression. [PDF]

Glia
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Peiró-Moreno C, Chara JC, Marshall-Phelps K, Ugarte-Arakistain I, Calovi S, De Almeida RG, Domercq M, Matute C.   +7 more
europepmc   +3 more sources

MHC class I and II expression and induction in oligodendrocytes varies with age [PDF]

Scientific Reports
Oligodendroglia expressing major histocompatibility complex (MHC) molecules have become of central interest in multiple sclerosis (MS) research, but their role in aging is still being elucidated.
Riley B. Catenacci, Danny Galleguillos, Adriana Rhodes, Sloan Phillips, Peter A. Calabresi   +4 more
doaj   +2 more sources

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia [PDF]

J Neurosci Res
This study shows that the blood‐derived molecule, Fibrinogen, has a differential effect on human Oligodendroglial (OL) cells. Fibrinogen, when added in vitro, leads to aberrant differentiation of OL‐precursors towards an astrocytic fate. On the other hand, when added into the culture of mature OLs, fibrinogen increases myelination capacity.
Blaszczyk G, Weng C, Mohammadnia A, Cui Q, Giurleo A, Groh A, Plouffe C, Sirois J, Piscopo V, Yaqubi M, Taqvi A, Cassidy E, Martin L, Hall J, Dudley R, Srour M, Zandee S, Klement W, Larouche S, Prat A, Durcan T, Stratton J, Antel J, Moore G.   +23 more
europepmc   +2 more sources

Oligodendroglial Densities and Myelin Structure Are Altered in TDP-43 Related Amyotrophic Lateral Sclerosis. [PDF]

Glia
TDP‐43Q331K mice exhibit altered proliferative dynamics in oligodendrocytes and their precursors. Oligodendroglial cell death is evident in TDP‐43Q331K mice. TDP‐43Q331K mice display altered myelin reflectance and pathology in the spinal cord. ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the ...
Lewis KN, Craig GA, Mason J, Tomas D, Cuic B, Walker AK, Gonsalvez DG, Turner BJ, Barton SK.   +8 more
europepmc   +2 more sources

An Autopsy Case With Fragile X-Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System. [PDF]

Neuropathology
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Shioya A, Ishii K, Sato T, Noguchi M, Tamaoka A, Saito Y.   +5 more
europepmc   +2 more sources

Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication [PDF]

Nature Communications
Emerging evidence links oligodendrocyte (OL) lineage cells and myelin to cognitive processes, yet the role of myelination in shaping neuronal networks critical for cognitive tasks remains unknown.
Fabrice Plaisier, Cristóbal Ibaceta-González, Hasni Khelfaoui, Adrianne E. S. Watson, Corinne Poilbout, Anastassia Voronova, María Cecilia Angulo   +6 more
doaj   +2 more sources

Distinct patterns of oligodendroglial dysfunction in neurodegenerative diseases [PDF]

Alzheimers Dement
Abstract Background Oligodendroglia are a major class of glial cell that play critical roles in myelination and neuronal support. Involvement of oligodendroglia is well‐known pathologically in frontotemporal lobar degeneration with tau (FTLD‐tau) and TDP‐43 (FTLD‐TDP) pathology, Alzheimer's disease (AD) and multiple system atrophy (MSA). However, their
Forrest S, Kane M, Knott S, Kovacs G.
europepmc   +2 more sources

The next generation of spatial transcriptomics and AI to understand complex interactions between glial cells [PDF]

Alzheimers Dement
Abstract Emerging research highlights the significant contributions of non‐neuronal cells—astrocytes, microglia, and oligodendrocytes—in Alzheimer's disease (AD). These glial cells are not only implicated in neuroinflammation, synaptic dysfunction, and neurodegeneration but also engage in highly dynamic crosstalk that modulates key pathological ...
Das S.
europepmc   +2 more sources

Identification of candidate causal risk genes and pathways in Alzheimer's disease and Lewy body dementia [PDF]

Alzheimers Dement
Abstract Background The neurodegenerative disorders Alzheimer's disease (AD) and Lewy body dementia (LBD) share genetic and clinicopathological overlap and may constitute a disease spectrum. Common variant genome‐wide association studies (GWASs) have uncovered AD and LBD etiology.
Picarello D, Adams D, Patel T, Fulton‐Howard B, Chia R, Comertpay B, Goate A, Kozlenkov A, Dracheva S, Traynor B, Scholz S, Marcora E, Renton A.   +12 more
europepmc   +2 more sources

Post-synaptic density proteins in oligodendrocytes are required for activity-dependent myelin sheath growth [PDF]

iScience
Summary: Neuronal activity regulates myelination in the central nervous system, highlighting the critical importance of axon-oligodendrocyte communications in myelin physiology and function.
Mary-Amélie Masson, Mariana Graciarena, Marion Porte, Brahim Nait-Oumesmar   +3 more
doaj   +2 more sources