Results 1 to 10 of about 9,077 (165)

Chromatin remodelers in oligodendroglia [PDF]

Glia, 2020
AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras, Corentine Marie, Chuntao Zhao, Qing Richard Lu   +3 more
openaire   +5 more sources

Beyond Myelination: Possible Roles of the Immune Proteasome in Oligodendroglial Homeostasis and Dysfunction

Frontiers in Neuroscience, 2022
Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons in their mature stages. Dysfunction in this lineage occurs when early stage OPCs are not able to differentiate to replace dying Mature Myelinating Oligodendrocytes ...
Miguel M. Madeira, Miguel M. Madeira, Miguel M. Madeira, Zachary Hage, Zachary Hage, Stella E. Tsirka, Stella E. Tsirka, Stella E. Tsirka   +7 more
doaj   +1 more source

Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes [PDF]

Diabetes & Metabolism Journal, 2022
As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis.
Xiaolong Li, Yan Cai, Zuo Zhang, Jiyin Zhou   +3 more
doaj   +1 more source

Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia

Glia, Volume 71, Issue 2, Page 334-349, February 2023., 2023
Main Points Defined a pig microglial transcriptome signature comprising 239 genes. Demonstrated regional variance in the pig microglial transcriptome across the brain. Revealed similarity of pig microglial gene expression to that of human and mouse microglia.
Barbara B. Shih, Sarah M. Brown, Jack Barrington, Lucas Lefevre, Neil A. Mabbott, Josef Priller, Gerard Thompson, Alistair B. Lawrence, Barry W. McColl   +8 more
wiley   +1 more source

Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation

Genome Biology, 2022
Background Circular RNAs (circRNAs), a novel class of poorly conserved non-coding RNAs that regulate gene expression, are highly enriched in the human brain.
Yangping Li, Feng Wang, Peng Teng, Li Ku, Li Chen, Yue Feng, Bing Yao   +6 more
doaj   +1 more source

Oligodendroglial Heterogeneity in Neuropsychiatric Disease

Life, 2021
Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and ...
Sunniva M. K. Bøstrand, Anna Williams
doaj   +1 more source

DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice

Frontiers in Neuroscience, 2021
Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial dysfunction and/or disruption of white matter integrity are found in the brains of patients with schizophrenia.
Xianjun Chen, Xianjun Chen, Nan-Xin Huang, Yong-Jie Cheng, Qi-Yan Cai, Yan-Ping Tian, Xing-Shu Chen, Xing-Shu Chen, Lan Xiao   +8 more
doaj   +1 more source

Dynamic induction of the myelin‐associated growth inhibitor Nogo‐A in perilesional plasticity regions after human spinal cord injury

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Nogo‐A oligodendrocytes expression emerges at perilesional regions over time and suggests an extended therapeutical window for anti‐Nogo‐A pathway trageting interventrions beyond four weeks in patients after spinal cord injury. Abstract The myelin‐associated inhibitor Nogo‐A (Reticulon 4, RTN4) restricts axonal outgrowth, plasticity, and neural ...
Carmen Schwaiger, Thomas Haider, Verena Endmayr, Tobias Zrzavy, Victoria E. Gruber, Gerda Ricken, Anika Simonovska, Simon Hametner, Jan M. Schwab, Romana Höftberger   +9 more
wiley   +1 more source

Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain

European Journal of Neuroscience, Volume 56, Issue 12, Page 6099-6114, December 2022., 2022
Using environmental enrichment to physiologically induce neuroplasticity in the young adult mouse, we find dynamic structural remodelling of axons and their pre‐existing myelin sheaths. Additionally, we find that oligodendrocytes respond primarily with an increase in differentiation and regionally specific decreases in progenitor density. These results
Madeline Nicholson, Rhiannon J. Wood, David G. Gonsalvez, Anthony J. Hannan, Jessica L. Fletcher, Junhua Xiao, Simon S. Murray   +6 more
wiley   +1 more source

Ewing and Ewing‐like sarcomas: A morphological guide through genetically‐defined entities

Pathology International, Volume 73, Issue 1, Page 12-26, January 2023., 2023
Abstract The fifth edition of the World Health Organization classification of soft tissue and bone tumors redefined Ewing sarcoma by fusions between EWSR1/FUS and ETS family of transcription factors, and recognized three tumor groups among Ewing‐like sarcoma: CIC‐rearranged sarcoma, sarcoma with BCOR genetic alterations, and round cell sarcoma with ...
Akihiko Yoshida
wiley   +1 more source