Results 31 to 40 of about 15,075 (153)

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]

, 2017
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett, Brück, Brück, Clark, Cunningham, Foote, Fünfschilling, Gudi, Hiremath, Hiremath, Irvine, Irvine, Kornek, Kuhlmann, Kutzelnigg, Lassmann, Lassmann, Lee, Lindner, Lindner, Lucchinetti, Manrique-Hoyos, Mason, Matsushima, McKenzie, Mildner, Morrison, Murray, Nikic, Otsuka, Patrikios, Pierce, Schuh, Simons, Singh, Skripuletz, Sorbara, Stidworthy, Trapp   +38 more
core   +1 more source

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP‐43A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

Neuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón, Cristina Benito‐Casado, Carmen María Fernández‐Martos, María José Polanco Mora   +3 more
wiley   +1 more source

APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]

, 1993
Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Beyreuther, K., Dichgans, Martin, König, G., Masters, C. L., Mönning, U., Sandbrink, R.   +5 more
core   +1 more source

The expanding toolkit of translating ribosome affinity purification [PDF]

, 2017
Translating ribosome affinity purification is a method initially developed for profiling mRNA from genetically defined cell types in complex tissues. It has been applied both to identify target molecules in cell types that are important for controlling a
Dougherty, Joseph D
core   +2 more sources

Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

Aging Cell, Volume 25, Issue 1, January 2026.
Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio, Christina Dimovasili, Yuchen Liu, Bingtian Ye, Jou‐Hsuan Roxie Lee, Molly Hartigan, Benjamin Bouchard, Madelyn Ray, Bryce Conner, Kelli L. Vaughan, Julie A. Mattison, Tara L. Moore, Chao Zhang, Douglas L. Rosene   +13 more
wiley   +1 more source

Phenotype overlap in glial cell populations: astroglia, oligodendroglia and NG-2(+) cells. [PDF]

, 2015
The extent to which NG-2(+) cells form a distinct population separate from astrocytes is central to understanding whether this important cell class is wholly an oligodendrocyte precursor cell (OPC) or has additional functions akin to those classically ...
Alix, Alix, Arranz, Badrah Alghamdi, Barres, Bergles, Bergles, Butt, Carmen, Carroll, Casper, Chiu, Choi, Choi, Choi, Chung, Clarke, Diers-Fenger, Dimou, Dyer, Dyer, Federoff, Franklin, Godfraind, Grass, Greenwood, Guo, Hamilton, He, Hirsch, Honsa, Kang, Karram, Komitova, Komitova, Kukley, Leoni, Levine, Levine, Levison, Liu, Lord, Lytle, Malatesta, Matthias, Merchan, Michalski, Nair, Nishiyama, Nishiyama, Ong, Peters, Polito, Raff, Redwine, Reyners, Richardson, Rivers, Robert Fern, Skoff, Skoff, Small, Spassky, Vaughn, Vaughn, Vaughn, Wigley, Wilson, Windrem, Wolff, Wu, Yuan, Zerlin, Zhu, Zhu, Ziskin   +75 more
core   +3 more sources

Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells [PDF]

, 2004
Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. NSCs can be directly isolated from fetal or adult nervous tissue,
Boehm, Bernhard O., Brenner, Rolf, Fiedler, Jörg, Gastl, Regina, Hermann, Andreas, Lerche, Holger, Liebau, Stefan, Maisel, Martina, Popa, M. Oana, Schwarz, Johannes, Storch, Alexander   +10 more
core  

Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis. [PDF]

, 2012
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Rivera, Francisco J
core   +2 more sources

Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease. [PDF]

, 2019
Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by chronic neuroinflammation, demyelination, and axonal damage. Infiltration of activated lymphocytes and myeloid cells are thought to be primarily responsible for white ...
Adami, Ager, Aharonowiz, Anghelina, Ben-Hur, Ben-Hur, Bergmann, Bergmann, Blanc, Blanc, Blurton-Jones, Brnic, Brustle, Cantuti-Castelvetri, Carbajal, Chang, Chen, Chen, Chucair-Elliott, Dandekar, Deshmukh, Dunnett, Fleming, Fleming, Frampton, Gage, Giovannoni, Glass, Gonzalez, Greenberg, Gupta, Halfpenny, Hardison, Hatch, Healy, Hosking, Huang, Ireland, Karamita, Keirstead, Kendall, Kerschensteiner, Kucharova, Lane, Lassmann, Lassmann, Lin, Lindborg, Lucchinetti, Mangale, Marie, Mei, Mei, Mei, Minagawa, Muller, Neumann, Oksenberg, Palfi, Parra, Pewe, Phares, Phillips, Picard-Riera, Plaisted, Plaisted, Pluchino, Pluchino, Poser, Prineas, Prineas, Ramakrishna, Redwine, Reidling, Rowe, Roy, Ruckh, Ruller, Salazar, Sarma, Schaumburg, Schlesinger, Smith, Steinman, Stohlman, Tabor-Godwin, Totoiu, Trandem, Traugott, Wang, Weinger, Weinger, Weinshenker, Wheeler, Whitman, Wu, Yagita, Zhang, Zhou, Zhu   +99 more
core   +1 more source

Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre‐Synapse and Promote Synaptic Pruning

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
Microglial EVs deliver C1q to pre‐synapses and promote synaptic pruning in vitro. C9orf72 KO microglia release more C1q‐storing EVs compared to WT and engulf more synapses in the hippocampus during the pruning period. Production of C1q‐storing EVs from WT microglia temporally correlates with the pruning period during postnatal development. ABSTRACT C1q
Giulia D'Arrigo, Giulia Cutugno, Maria Teresa Golia, Francesca Sironi, Marta Lombardi, Sara Francesca Colombo, Roberto Frigerio, Marina Cretich, Paola Gagni, Elisabetta Battocchio, Cristiana Barone, Emanuele Azzoni, Sonia Bellini, Claudia Saraceno, Roberta Ghidoni, Caterina Bendotti, Rosa Chiara Paolicelli, Martina Gabrielli, Claudia Verderio   +18 more
wiley   +1 more source