Results 41 to 50 of about 17,381 (266)

Oligodendroglia: metabolic supporters of axons [PDF]

Trends in Cell Biology, 2013
Axons are specialized extensions of neurons that are critical for the organization of the nervous system. To maintain function in axons that often extend some distance from the cell body, specialized mechanisms of energy delivery are likely to be necessary.
Jeffrey D. Rothstein, Brett M. Morrison, Youngjin Lee   +2 more
openaire   +3 more sources

Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers

Cells, 2021
During embryonic development, progenitor cells are progressively restricted in their potential to generate different neural cells. A specific progenitor cell type, the radial glial cells, divides symmetrically and then asymmetrically to produce neurons ...
Ana Cristina Ojalvo-Sanz, Laura López-Mascaraque   +1 more
doaj   +1 more source

Glioneuronal apoptosis and neuroinflammation in drug resistant temporal lobe epilepsy

Неврология, нейропсихиатрия, психосоматика, 2023
The study of glioneuronal apoptosis and neuroinflammation is extremely important for understanding the causes of epilepsy. Currently, the focus is on neuronal apoptosis and certain aspects of neuroinflammation, while glial apoptosis remains poorly ...
T. V. Sokolova, A. V. Litovchenko, N. M. Paramonova, V. R. Kasumov, S. V. Kravtsova, V. G. Nezdorovina, D. A. Sitovskaya, E. N. Skiteva, E. D. Bazhanova, Y. M. Zabrodskaya   +9 more
doaj   +1 more source

The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

Frontiers in Cellular Neuroscience, 2023
Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the
Mohanlall Narine, Mohanlall Narine, Maryam A. Azmi, Martin Umali, Ashley Volz, Holly Colognato   +5 more
doaj   +1 more source

Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]

, 2019
Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain, Clark, Kaitlin, Farmer, Diana, Guo, Fuzheng, Kreutzberg, Nicole, Kumar, Priyadarsini, Paxton, Zachary, Pivetti, Christopher, Reed, Camille, Wang, Aijun, Wang, Yan, Zhang, Sheng   +11 more
core   +2 more sources

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. [PDF]

, 2013
Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons ...
Bergles, Dwight E, Cleveland, Don W, Fukaya, Masahiro, Kang, Shin H, Li, Ying, Lorenzini, Ileana, Ostrow, Lyle W, Rothstein, Jeffrey D   +7 more
core   +2 more sources

Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells [PDF]

International Journal of Molecular Sciences, 2016
Endogenous bornavirus-like nucleoprotein elements (EBLNs) have been discovered in the genomes of various animals including humans, whose functions have been seldom studied.
Peng He, Lin Sun, Dan Zhu, Hong Zhang, Liang Zhang, Yujie Guo, Siwen Liu, Jingjing Zhou, Xiaoyan Xu, Peng Xie   +9 more
openalex   +2 more sources

MicroRNA-23a promotes myelination in the central nervous system. [PDF]

, 2013
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui, Heng, Mary Y, Huang, Yong, Lin, Shu-Ting, Ptácek, Louis J, Zhang, Luoying   +5 more
core   +2 more sources

Oligodendroglia and neurotrophic factors in neurodegeneration

Neuroscience Bulletin, 2013
Myelination by oligodendroglial cells (OLs) enables the propagation of action potentials along neuronal axons, which is essential for rapid information flow in the central nervous system. Besides saltatory conduction, the myelin sheath also protects axons against inflammatory and oxidative insults. Loss of myelin results in axonal damage and ultimately
Andrew N. Bankston, Yue Feng, Mariana D. Mandler   +2 more
openaire   +4 more sources

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]

, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Fillon, Gwenaëlle, Gai, Wei-Ping, Gysbers, Amanda, Haass, Christian, Halliday, Glenda,, Hansen, Hanne, Jensen, Poul, Kahle, Philipp, Kragh, Christine, Lubetzki, Catherine, Neumann, Manuela, Richter-Landsberg, Christian, Smith, Wanli, Zalc, Bernard   +13 more
core   +3 more sources