Results 41 to 50 of about 9,077 (165)

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

eLife, 2020
Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express ...
Magali Macchi, Karine Magalon, Céline Zimmer, Elitsa Peeva, Bilal El Waly, Béatrice Brousse, Sarah Jaekel, Kay Grobe, Friedemann Kiefer, Anna Williams, Myriam Cayre, Pascale Durbec   +11 more
doaj   +1 more source

Perineuronal satellite neuroglia in the telencephalon of New Caledonian crows and other Passeriformes: evidence of satellite glial cells in the central nervous system of healthy birds? [PDF]

PeerJ, 2013
Glia have been implicated in a variety of functions in the central nervous system, including the control of the neuronal extracellular space, synaptic plasticity and transmission, development and adult neurogenesis.
Felipe S. Medina, Gavin R. Hunt, Russell D. Gray, J. Martin Wild, M. Fabiana Kubke   +4 more
doaj   +2 more sources

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice

Glia, EarlyView.
Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration, and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying mechanisms ...
Niki Ktena, Dimitrios Spyridakos, Alexandros Georgilis, Ilias Kalafatakis, Efstathia Thomoglou, Angeliki Kolaxi, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
wiley   +1 more source

The Absolute Number of Oligodendrocytes in the Adult Mouse Brain

Frontiers in Neuroanatomy, 2018
The central nervous system is a highly complex network composed of various cell types, each one with different subpopulations. Each cell type has distinct roles for the functional operation of circuits, and ultimately, for brain physiology in general ...
Bruna Valério-Gomes, Daniel M. Guimarães, Diego Szczupak, Roberto Lent, Roberto Lent   +4 more
doaj   +1 more source

Correlations between Dysphagia Severity Scale Scores and Clinical Indices in Individuals with Multiple System Atrophy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dysphagia significantly impacts prognosis in individuals with multiple system atrophy (MSA). While video‐based assessments are practical, their limited availability highlights the need for a simple tool such as the Dysphagia Severity Scale (DSS) in clinical practice.
Ryunosuke Nagao, Yasuaki Mizutani, Kazuya Kawabata, Junichiro Yoshimoto, Yoko Inamoto, Seiko Shibata, Mizuki Ito, Yohei Otaka, Hirohisa Watanabe   +8 more
wiley   +1 more source

Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders

Brain Sciences, 2017
Alcoholism is a chronic relapsing disorder with few therapeutic strategies that address the core pathophysiology. Brain tissue loss and oxidative damage are key components of alcoholism, such that reversal of these phenomena may help break the addictive ...
Chitra D. Mandyam, Emmanuel G. Villalpando, Noah L. Steiner, Leon W. Quach, McKenzie J. Fannon, Sucharita S. Somkuwar   +5 more
doaj   +1 more source

Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

eLife, 2022
The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the ...
Emeric Merour, Hatem Hmidan, Corentine Marie, Pierre-Henri Helou, Haiyang Lu, Antoine Potel, Jean-Baptiste Hure, Adrien Clavairoly, Yi Ping Shih, Salman Goudarzi, Sebastien Dussaud, Philippe Ravassard, Sassan Hafizi, Su Hao Lo, Bassem A Hassan, Carlos Parras   +15 more
doaj   +1 more source

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells

Movement Disorders, EarlyView.
Abstract Background The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP). Objective To investigate the association between CNVs and structural forms on 17q.21.31 with the risk of PSP.
Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po‐Liang Cheng, Ya‐Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente‐Banuet, Chong Li, Kurt Farrell, Catriona Mclean, Laura Molina‐Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano‐Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili‐Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivianna M. Van Deerlin, Edward B. Lee, Charles L. White III, Huw R. Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yaroslau Compta, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li‐San Wang, PSP Genetics Study Group, Anthony E. Lang, Murray Grossman, David S. Knopman, Lon S. Schneider, Rachelle S. Doody, Andrew Lees, Lawrence I. Golbe, David R. Williams, Jean‐Cristophe Corvol, Albert Ludolph, David Burn, Stefan Lorenzl, Erik D. Roberson, Mary Koestler, Clifford R. Jack Jr, Christopher Randolph, Iryna V. Lobach, Hilary W. Heuer, Illana Gozes, Lesley Parker, Steve Whitaker, Joe Hirman, Alistair J. Stewart, Michael Gold, Bruce H. Morimoto, Jochen Herms, Ellen Gelpi, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Jung‐Ying Tzeng, Daniel H. Geschwind, Gerard D. Schellenberg, Wan‐Ping Lee   +93 more
wiley   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders

Frontiers in Molecular Neuroscience, 2018
Depressive disorders are complex, multifactorial mental disorders with unknown neurobiology. Numerous theories aim to explain the pathophysiology. According to the “gliocentric theory”, glial abnormalities are responsible for the development of the ...
Boldizsár Czéh, Boldizsár Czéh, Szilvia A. Nagy, Szilvia A. Nagy, Szilvia A. Nagy, Szilvia A. Nagy   +5 more
doaj   +1 more source