Results 61 to 70 of about 9,077 (165)

Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects

Glia, Volume 73, Issue 3, Page 539-573, March 2025.
Main Point Graphical overview of the literature summarized in this review, spanning glia cells and levels of omics analysis present on Alzheimer's disease. ABSTRACT Alzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐layered complexity in its molecular etiology.
Özkan İş, Yuhao Min, Xue Wang, Stephanie R. Oatman, Ann Abraham Daniel, Nilüfer Ertekin‐Taner   +5 more
wiley   +1 more source

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Acta Neuropathologica Communications, 2017
Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather ...
Ronald J. Mandel, David J. Marmion, Deniz Kirik, Yaping Chu, Clifford Heindel, Thomas McCown, Steven J. Gray, Jeffrey H. Kordower   +7 more
doaj   +1 more source

Oligodendroglia are emerging players in several forms of learning and memory

Communications Biology, 2022
A Perspective highlights current evidence that supports oligodendrocytes and their progenitors’ involvement in cognition and proposes that our understanding of learning and memory can be expanded beyond the classic view of synaptic plasticity to a system-
Maxime Munyeshyaka, R. Douglas Fields
doaj   +1 more source

Oligodendrocyte Slc48a1 (Hrg1) encodes a functional heme transporter required for myelin integrity

Glia, Volume 73, Issue 2, Page 399-421, February 2025.
Main Points Hrg1 is a heme transporter in myelin. Heme is an auxiliary source of iron for oligodendrocytes and required for Mag expression. Hrg1 KO mice have increased periaxonal space due to decreased levels of Mag. Abstract Oligodendrocytes (OLs) of the central nervous system require iron for proteolipid biosynthesis during the myelination process ...
John H. Stockley, Adrien M. Vaquie, Zhaoyang Xu, Theresa Bartels, Gregory D. Jordan, Staffan Holmqvist, Simon Gunter, Guy Lam, Daniel Yamamoto, Rini H. Pek, Ian G. Chambers, Andrew S. Rock, Myfanwy Hill, Chao Zhao, Scott Dillon, Robin J. M. Franklin, Rosemary O'Connor, David M. Bodine, Iqbal Hamza, David H. Rowitch   +19 more
wiley   +1 more source

Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia

Cell Reports, 2023
Summary: Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology.
Raquel Garza, Yogita Sharma, Diahann A.M. Atacho, Arun Thiruvalluvan, Sami Abu Hamdeh, Marie E. Jönsson, Vivien Horvath, Anita Adami, Martin Ingelsson, Patric Jern, Molly Gale Hammell, Elisabet Englund, Agnete Kirkeby, Johan Jakobsson, Niklas Marklund   +14 more
doaj  

Late‐Onset Krabbe Disease: Case Report of Two Patients in a Chinese Family and Literature Review

Molecular Genetics &Genomic Medicine, Volume 13, Issue 2, February 2025.
We report two cases of late‐onset Krabbe disease (KD) from a Chinese family. This study broadens the consideration of KD in the diagnosis of patients presenting with muscle weakness and deformities in the lower limbs. ABSTRACT Background Krabbe disease (KD; globoid cell leucodystrophy) is a rare autosomal recessive lipid storage disorder that affects ...
Yujun Sun, Jiayuan Zheng, Lei He, Xiaojuan Li, Wenzhou Liu, Jionglin Wu, Jiajie Li, Taolue Zhou, Gang Zeng, Weidong Song, Yanbo Chen   +10 more
wiley   +1 more source

Iron‐associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

Alzheimer's &Dementia, Volume 21, Issue 1, January 2025.
Hypothesis: AD brain lipid peroxidation is driven by increased brain iron and decreased antioxidant defenses. Schema shows proteins that mediate iron metabolism in relation to lipid peroxidation (HNE) and antioxidant defenses in the prefrontal cortex.
Max A. Thorwald, Jose A. Godoy‐Lugo, Gilberto Garcia, Justine Silva, Minhoo Kim, Amy Christensen, Wendy J. Mack, Elizabeth Head, Peggy A. O'Day, Bérénice A. Benayoun, Todd E. Morgan, Christian J. Pike, Ryo Higuchi‐Sanabria, Henry Jay Forman, Caleb E. Finch   +14 more
wiley   +1 more source

Editorial: Non-neuronal cell heterogeneity in the nervous system during health and disease

Frontiers in Cellular Neuroscience, 2022
Greg J. Duncan, Peggy Assinck, Jo Anne Stratton, Bahareh Ajami, Jason R. Plemel, Jason R. Plemel, Jason R. Plemel   +6 more
doaj   +1 more source

Degeneração mucóide da oligodendroglia em um caso de enfermidade do grupo Wilson

Arquivos de Neuro-Psiquiatria, 1944
Recordam-se, no presente trabalho, as alterações da oligodendroglia em particular a degeneração mucóide. Relata-se sinteticamente um caso do grupo Wilson - espasmo de torção - em que havia degeneração mucóide da oligodendroglia predominantemente na ...
A. Austregésilo Filho
doaj  

Oligodendroglia Are Particularly Vulnerable to Oxidative Damage After Neurotrauma In Vivo

Journal of Experimental Neuroscience, 2018
In the paper “Oligodendroglia are particularly vulnerable to oxidative damage after neurotrauma in vivo,” we determined the extent of oxidative damage to specific cellular subpopulations and structures within regions vulnerable to secondary degeneration ...
Marcus Giacci, Melinda Fitzgerald
doaj   +1 more source