Results 71 to 80 of about 17,381 (266)

Live-cell metabolic analysis of oligodendroglia isolated from postnatal mouse brain and spinal cord

STAR Protocols, 2022
Summary: This protocol describes isolation and live-cell metabolic analysis of O4+ oligodendroglia from brain and spinal cord of postnatal mice. We have optimized existing protocols for O4+ isolation from neonatal brain and expanded the protocol to ...
Luipa Khandker, Teresa L. Wood
doaj  

Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease. [PDF]

, 2019
Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by chronic neuroinflammation, demyelination, and axonal damage. Infiltration of activated lymphocytes and myeloid cells are thought to be primarily responsible for white ...
Adami, Ager, Aharonowiz, Anghelina, Ben-Hur, Ben-Hur, Bergmann, Bergmann, Blanc, Blanc, Blurton-Jones, Brnic, Brustle, Cantuti-Castelvetri, Carbajal, Chang, Chen, Chen, Chucair-Elliott, Dandekar, Deshmukh, Dunnett, Fleming, Fleming, Frampton, Gage, Giovannoni, Glass, Gonzalez, Greenberg, Gupta, Halfpenny, Hardison, Hatch, Healy, Hosking, Huang, Ireland, Karamita, Keirstead, Kendall, Kerschensteiner, Kucharova, Lane, Lassmann, Lassmann, Lin, Lindborg, Lucchinetti, Mangale, Marie, Mei, Mei, Mei, Minagawa, Muller, Neumann, Oksenberg, Palfi, Parra, Pewe, Phares, Phillips, Picard-Riera, Plaisted, Plaisted, Pluchino, Pluchino, Poser, Prineas, Prineas, Ramakrishna, Redwine, Reidling, Rowe, Roy, Ruckh, Ruller, Salazar, Sarma, Schaumburg, Schlesinger, Smith, Steinman, Stohlman, Tabor-Godwin, Totoiu, Trandem, Traugott, Wang, Weinger, Weinger, Weinshenker, Wheeler, Whitman, Wu, Yagita, Zhang, Zhou, Zhu   +99 more
core   +1 more source

Early proliferation does not prevent the loss of oligodendrocyte progenitor cells during the chronic phase of secondary degeneration in a CNS white matter tract. [PDF]

PLoS ONE, 2013
Partial injury to the central nervous system (CNS) is exacerbated by additional loss of neurons and glia via toxic events known as secondary degeneration.
Sophie C Payne, Carole A Bartlett, Donna L Savigni, Alan R Harvey, Sarah A Dunlop, Melinda Fitzgerald   +5 more
doaj   +1 more source

Contribution of RNA/DNA Binding Protein Dysfunction in Oligodendrocytes in the Pathogenesis of the Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Spectrum Diseases

Frontiers in Neuroscience, 2021
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders, often considered as the extreme manifestations of a disease spectrum, as they share similar pathomechanisms.
Chiara F. Valori, Manuela Neumann, Manuela Neumann   +2 more
doaj   +1 more source

Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

Nature Communications, 2019
The first wave of oligodendrocyte precursor cells (firstOPCs) and most GABAergic interneurons share common embryonic origins. Cortical firstOPCs are thought to be replaced by other OPC populations shortly after birth, maintaining a consistent OPC density
D. Orduz, N. Benamer, Domiziana Ortolani, E. Coppola, Lisa Vigier, A. Pierani, M. C. Angulo   +6 more
semanticscholar   +1 more source

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

eLife, 2020
Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express ...
Magali Macchi, Karine Magalon, Céline Zimmer, Elitsa Peeva, Bilal El Waly, Béatrice Brousse, Sarah Jaekel, Kay Grobe, Friedemann Kiefer, Anna Williams, Myriam Cayre, Pascale Durbec   +11 more
doaj   +1 more source

Perineuronal satellite neuroglia in the telencephalon of New Caledonian crows and other Passeriformes: evidence of satellite glial cells in the central nervous system of healthy birds? [PDF]

PeerJ, 2013
Glia have been implicated in a variety of functions in the central nervous system, including the control of the neuronal extracellular space, synaptic plasticity and transmission, development and adult neurogenesis.
Felipe S. Medina, Gavin R. Hunt, Russell D. Gray, J. Martin Wild, M. Fabiana Kubke   +4 more
doaj   +2 more sources

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Annals of Neurology, EarlyView.
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr., Bruce A. C. Cree, Stephen L. Hauser   +2 more
wiley   +1 more source

Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy [PDF]

, 2014
Corticosteroid (CS) therapy is used widely in the treatment of a range of pathologies, but can delay production of myelin, the insulating sheath around central nervous system nerve fibers.
Chari, DM, Emes, RD, Jenkins, SI, Khong, M, Mann, CL, Pickard, MR, Smith, HL   +6 more
core   +5 more sources

Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders

Frontiers in Molecular Neuroscience, 2018
Depressive disorders are complex, multifactorial mental disorders with unknown neurobiology. Numerous theories aim to explain the pathophysiology. According to the “gliocentric theory”, glial abnormalities are responsible for the development of the ...
Boldizsár Czéh, Boldizsár Czéh, Szilvia A. Nagy, Szilvia A. Nagy, Szilvia A. Nagy, Szilvia A. Nagy   +5 more
doaj   +1 more source