Results 71 to 80 of about 15,473 (242)

Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

eLife, 2022
The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the ...
Emeric Merour, Hatem Hmidan, Corentine Marie, Pierre-Henri Helou, Haiyang Lu, Antoine Potel, Jean-Baptiste Hure, Adrien Clavairoly, Yi Ping Shih, Salman Goudarzi, Sebastien Dussaud, Philippe Ravassard, Sassan Hafizi, Su Hao Lo, Bassem A Hassan, Carlos Parras   +15 more
doaj   +1 more source

Expression of a beta 1-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination. [PDF]

, 1994
We have investigated the expression of integrins by rat oligodendroglia grown in primary culture and the functional role of these proteins in myelinogenesis.
Malek-Hedayat, S, Rome, LH
core  

Phenotype overlap in glial cell populations: astroglia, oligodendroglia and NG-2(+) cells. [PDF]

, 2015
The extent to which NG-2(+) cells form a distinct population separate from astrocytes is central to understanding whether this important cell class is wholly an oligodendrocyte precursor cell (OPC) or has additional functions akin to those classically ...
Alix, Alix, Arranz, Badrah Alghamdi, Barres, Bergles, Bergles, Butt, Carmen, Carroll, Casper, Chiu, Choi, Choi, Choi, Chung, Clarke, Diers-Fenger, Dimou, Dyer, Dyer, Federoff, Franklin, Godfraind, Grass, Greenwood, Guo, Hamilton, He, Hirsch, Honsa, Kang, Karram, Komitova, Komitova, Kukley, Leoni, Levine, Levine, Levison, Liu, Lord, Lytle, Malatesta, Matthias, Merchan, Michalski, Nair, Nishiyama, Nishiyama, Ong, Peters, Polito, Raff, Redwine, Reyners, Richardson, Rivers, Robert Fern, Skoff, Skoff, Small, Spassky, Vaughn, Vaughn, Vaughn, Wigley, Wilson, Windrem, Wolff, Wu, Yuan, Zerlin, Zhu, Zhu, Ziskin   +75 more
core   +3 more sources

What determines the timing of epilepsy surgery in children with cortical malformations and low‐grade epilepsy‐associated tumors?

Epilepsia Open, Volume 10, Issue 5, Page 1345-1352, October 2025.
Abstract Objectives Timely referral and efficient presurgical evaluation are important to optimize postoperative seizure and developmental outcomes in epilepsy surgery patients. We aimed to identify determinants of time intervals from epilepsy diagnosis to referral to specialized centers and epilepsy surgery in children with malformations of cortical ...
Maurits W. C. B. Sanders, Matyas Ebel, Aswin Chari, Merel Fleumer, Anca M. Vasilica, Maria H. Eriksson, Martin Tisdall, Barbora Splitkova, Anezka Belohlavkova, Willem M. Otte, Floor E. Jansen, J. Helen Cross, Kees P. J. Braun, Pavel Krsek   +13 more
wiley   +1 more source

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]

, 2017
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett, Brück, Brück, Clark, Cunningham, Foote, Fünfschilling, Gudi, Hiremath, Hiremath, Irvine, Irvine, Kornek, Kuhlmann, Kutzelnigg, Lassmann, Lassmann, Lee, Lindner, Lindner, Lucchinetti, Manrique-Hoyos, Mason, Matsushima, McKenzie, Mildner, Morrison, Murray, Nikic, Otsuka, Patrikios, Pierce, Schuh, Simons, Singh, Skripuletz, Sorbara, Stidworthy, Trapp   +38 more
core   +1 more source

Tyro3 deletion is protective in experimental autoimmune encephalomyelitis

Immunology &Cell Biology, Volume 103, Issue 9, Page 857-870, October 2025.
Multiple sclerosis pathogenesis involves the complex interplay between the peripheral immune response and the central nervous system. Gas6 is a promising therapy to promote remyelination; however, Gas6 and its receptors (the TAM receptor family) are widely expressed in both immune cells and the central nervous system. Our study demonstrates that global
Michele D Binder, Mohammad Asadian, Darnell Leepel, Gerry ZM Ma, Andrea Aprico, Liz Barreto‐Arce, Trevor J Kilpatrick, Sarrabeth Stone   +7 more
wiley   +1 more source

Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas [PDF]

, 2014
Prominin-1 (CD133) is a commonly used cancer stem cell marker in central nervous system (CNS) tumors including glioblastoma (GBM). Expression of Prom1 in cancer is thought to parallel expression and function in normal stem cells.
Haidar, Sam, Holmberg Olausson, Karl, Learner, Emily, Ligon, Keith L., Ling, Jason, Maire, Cecile L., Nistér, Monica   +6 more
core   +11 more sources

APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation [PDF]

, 1993
Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons.
Beyreuther, K., Dichgans, Martin, König, G., Masters, C. L., Mönning, U., Sandbrink, R.   +5 more
core   +1 more source

Oligodendroglia metabolically support axons and contribute to neurodegeneration [PDF]

Nature, 2012
Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration has not been determined, but lack of energy metabolites such as glucose or lactate has been proposed. Lactate is transported exclusively by monocarboxylate
Lee Youngjin, Morrison Brett M, Li Yun, Lengacher Sylvain, Farah Mohamed H, Hoffman Paul N, Liu Yiting, Tsingalia Akivaga, Jin Lin, Zhang Ping-Wu, Pellerin Luc, Magistretti Pierre J, Rothstein Jeffrey D   +12 more
openaire   +5 more sources

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Kaviya Chinnappa, Fiona Ballorin, Fiona Francis   +2 more
wiley   +1 more source