Results 171 to 180 of about 15,131 (222)

Distal peptide elongation by a protease-like ligase and two distinct carrier proteins.

Chem
Gude F, Bohne A, Dell M, Franke J, Dunbar KL, Groll M, Hertweck C.   +6 more
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Preparation of oligonucleotide-peptide conjugates

Bioconjugate Chemistry, 1991
A procedure for preparing oligonucleotide-peptide conjugates is presented. It is based on appending a maleimide group to the oligonucleotide for selective coupling to the thiol side chain of a cysteine residue in the peptide. A convenient chromatographic purification procedure, based on Fmoc-on/Fmoc-off, is described.
C H, Tung, M J, Rudolph, S, Stein
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Facile preparation of 3′oligonucleotide-peptide conjugates

Tetrahedron Letters, 1991
Abstract The solid phase synthesis of 3′ deoxyoligonucleotide (17 mer)-peptide conjugates is described. The oligonucleotide is complementary to the template strand of the measles virus in the region of the nucleocapsid protein on the 60 nucleotide leader RNA.
Carl D. Juby, Christopher D. Richardson, Roland Brousseau   +2 more
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Thermodynamic Melting Studies on Oligonucleotide-Peptide Conjugates

Nucleosides and Nucleotides, 1999
Abstract A small library of oligonucleotide-peptide conjugates has been prepared and studied to explore the influence of the various peptide side chain (cationic, anionic or hydrophobic) on the hybridation properties of the DNA.
C. Frier, J. G. Harrison, S. Balasubramanian   +2 more
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EFFICIENT SYNTHESIS OF OLIGONUCLEOTIDE-PEPTIDE CONJUGATES ON LARGE SCALE

Nucleosides, Nucleotides and Nucleic Acids, 2001
The conjugation of oligonucleotide phosphorothioates with antennapedia peptide was studied in detail to allow efficient preparation of the conjugates on up to 15 mumol scale. Under optimized conditions, the use of oligonucleotides and the peptide in an equimolecular ratio gave the desired conjugates in more than 60% isolated yield.
S O, Doronina, A P, Guzaev, M, Manoharan
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Sequence-specific RNA cleavage by oligonucleotide-peptide conjugates

Russian Chemical Bulletin, 2002
This paper considers the site-directed cleavage of the in vitro transcript of human tRNALys3 by the conjugate CNH2Gly(ArgLeu)3ArgLeuN—p-DAG—5"CCCTGGACCCTCAGAT3" (conjugate pep-1A) of the oligodeoxyribonucleotide 1A (CCCTGGACCCTCAGAT) with a peptide [LeuArg]4Gly attached at the 5" terminus of the oligonucleotide through diethylene glycol as a linker ...
N. L. Mironova, D. V. Pyshnyi, E. M. Ivanova, V. F. Zarytova, M. A. Zenkova, H. J. Gross, V. V. Vlassov   +6 more
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Synthesis of oligonucleotide–peptide conjugates using hydrazone chemical ligation

Tetrahedron Letters, 2002
Oligonucleotides constitute a class of potential therapeutic agents. Improvement of certain properties, such as cell-specific delivery, cellular uptake efficiency, intracellular distribution, and target specificity can be accomplished by covalent association to peptides [1], Rather than forming ionic oligonucleotide-peptide complexes, covalent ...
Nathalie Ollivier, Christophe Olivier, Catherine Gouyette, Tam Huynh-Dinh, Hélène Gras-Masse, Oleg Melnyk   +5 more
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ChemInform Abstract: Facile Preparation of 3′‐Oligonucleotide‐Peptide Conjugates.

ChemInform, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
C. D. JUBY, C. D. RICHARDSON, R. BROUSSEAU   +2 more
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RNA-Cleaving Oligonucleotide-Peptide Conjugates

2004
The most widely described artificial ribonucleases are designed on the basis of RNA-binding domains and low molecular weight constructs bearing functional groups of amino acid residues from catalytic centers of natural RNases: conjugates containing imidazole and carboxylate ions, guanidinium groups (see review Silnikov and Vlassov 200l).
N. L. Mironova, D. V. Pyshnyi, E. M. Ivanova   +2 more
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Synthesis of phosphorothioate oligonucleotide–peptide conjugates by solid phase fragment condensation

Bioorganic & Medicinal Chemistry Letters, 2007
Phosphorothioate oligonucleotide-peptide conjugates were synthesized by solid phase fragment condensation (SPFC). Arginine rich peptides could be successfully conjugated in 2.8-13.4% isolated yields. All the products were fully characterized by reversed phase HPLC and MALDI-TOF-MS to give satisfactory results.
Irmina, Diala, Akira, Osada, Shinji, Maruoka, Takashi, Imanisi, Satoshi, Murao, Taishi, Ato, Hideki, Ohba, Masayuki, Fujii   +7 more
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