Results 11 to 20 of about 15,131 (222)
Molecules, 2021 RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently ...
Yaroslav Staroseletz +7 more
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RNA-Peptide Conjugation through an Efficient Covalent Bond Formation
Applied Sciences, 2020 Many methods for modification of an oligonucleotide with a peptide have been developed to apply for the therapeutic and diagnostic applications or for the assembly of nanostructure.
Shun Nakano +3 more
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Antisense Inhibition of Human Telomerase by Phosphorothioate Oligonucleotide-Peptide Conjugates [PDF]
Nucleic Acids Symposium Series, 2008 Oligonucleotides can be covalently linked to peptides composed of any sequence of amino acids by SPFC. The peptides incorporated into the conjugates include nuclear localizing signals (NLS), nuclear export signals (NES), membrane fusion domain of some viral proteins and some designed peptides with amphipathic character.
Irmina, Diala +2 more
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Clinical advances of RNA therapeutics for treatment of neurological and neuromuscular diseases
RNA Biology, 2022 RNA therapeutics comprise a diverse group of oligonucleotide-based drugs such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short hairpin RNAs (shRNAs) that can be designed to selectively interact with drug targets currently ...
Anja Holm +3 more
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International Journal of Molecular Sciences, 2022 Oligonucleotide–peptide conjugates (OPCs) are a promising class of biologically active compounds with proven potential for improving nucleic acid therapeutics. OPCs are commonly recognized as an efficient instrument to enhance the cellular delivery of therapeutic nucleic acids.
Vladimir B. Tsvetkov +7 more
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Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance
Molecules, 2020 Irreversible destruction of disease-associated regulatory RNA sequences offers exciting opportunities for safe and powerful therapeutic interventions against human pathophysiology.
Olga Patutina +6 more
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Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids
Molecules, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris +3 more
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Synthesis of Oligonucleotide–Peptide Conjugates for Biomedical and Technological Applications [PDF]
, 2011 Oligonucleotide-peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides carrying peptide sequences at the 3'-end on a single support.
Aviñó, Anna +5 more
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Oligonucleotide-Peptide Conjugates: Solid-Phase Synthesis under Acidic Conditions and Use in ELISA Assays [PDF]
Molecules, 2012 Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides. A stepwise protocol using acid treatment for the final deprotection allowed the preparation of polypyrimidine ...
Anna Aviñó +4 more
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Molecular Therapy: Nucleic Acids, 2013 We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of ...
HaiFang Yin +9 more
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