Results 191 to 200 of about 15,131 (222)

Synthesis of Antisense Oligonucleotide−Peptide Conjugate Targeting to GLUT-1 in HepG-2 and MCF-7 Cells

Bioconjugate Chemistry, 2002
A simple procedure for the preparation of oligonucleotide-peptide conjugate was developed. p-Hydroxy-benzoic acid was used as a linker for the connection of the fragments of peptide and oligonucleotide. It was found that such formed linkage was stable under the conditions of conjugate synthesis.
Chang-Po, Chen, Xiao-Xu, Li, Liang-Ren, Zhang, Ji-Mei, Min, Judy Yuet-Wah, Chan, Kwok-Pui, Fung, Sheng-Qi, Wang, Li-He, Zhang   +7 more
openaire   +2 more sources

2'OMe Modification of Anti-miRNA-21 Oligonucleotide–Peptide Conjugate Improves Its Hybridization Properties and Catalytic Activity

Russian Journal of Bioorganic Chemistry, 2019
Abstract: Nowadays, application of miRNases—artificial ribonucleases aimed at degradation of noncoding RNAs, in particular, miRNAs—represents one of the novel experimental approaches to inhibit tumorigenesis. miRNases integrate in their structure an addressing oligonucleotide, which provides specific binding with miRNA target, and a catalytic group ...
Miroshnichenko, S. K., Amirloo, B., Bichenkova, E. V., Vlassov, V. V., Zenkova, M. A., Patutina, O. A.   +5 more
openaire   +1 more source

The Solution Synthesis of Antisense Oligonucleotide‐Peptide Conjugates Directly Linked via Phosphoramide Bond by Using a Fragment Coupling Approach

Nucleosides, Nucleotides and Nucleic Acids, 2004
To improve antisense oligonucleotide penetration inside cells, conjugates of oligonucleotides and cell-penetrating peptides, covalently linked through a phosphoramide bond, were prepared by a fragment coupling approach in the liquid phase. Two methods were used for this synthesis, i.e., phosphorylation of a peptide amino group by an oligonucleotide ...
Nataliya V, Sumbatyan, Vassili A, Mandrugin, Alain, Deroussent, Jean-Rémi, Bertrand, Zsuzsa, Majer, Claude, Malvy, Galina A, Korshunova, Miklos, Hollosi, Marina B, Gottikh   +8 more
openaire   +2 more sources

ds‐Oligonucleotide–Peptide Conjugates Featuring Peptides from the Leucine‐Zipper Region of Fos as Switchable Receptors for the Oncoprotein Jun

ChemBioChem, 2007
(Chemical Equation Presented) Synthetic ds-oligonucleotide-peptide conjugates in which the peptide features the leucine-zipper region of c-Fos are high-affinity and specific receptors for the oncoprotein Jun. The recognition strategy allows the Jun-trapping capability of the constructs to be switched by using appropriately designed ssDNAs. © 2007 Wiley-
Cecilia, Portela, Fernando, Albericio, Ramón, Eritja, Luis, Castedo, José L, Mascareñas   +4 more
openaire   +2 more sources

Synthesis of Oligodeoxynucleotides Containing N⁴-Mercaptoethylcytosine and Their Use in the Preparation of Oligonucleotide−Peptide Conjugates Carrying c-myc Tag-Sequence

Bioconjugate Chemistry, 1998
The preparation and properties of oligodeoxynucleotides containing mercaptoethyl groups at position N-4 of cytosine are described. The resulting thiol-oligodeoxynucleotides were reacted with a maleimido-peptide carrying the c-myc tag-sequence. The peptide-oligonucleotide conjugate is specifically recognized by an anti c-myc monoclonal antibody, thus ...
D, Gottschling, H, Seliger, G, Tarrasón, J, Piulats, R, Eritja   +4 more
openaire   +2 more sources

A Novel Synthesis of Oligonucleotide–Peptide Conjugates with a Base-Labile Phosphate Linker between the Two Components According to the Allyl-Protected Phosphoramidite Strategy

Tetrahedron, 2000
Abstract An efficient synthesis of base-labile nucleotide–peptide conjugates has been accomplished, in which the two components are directly linked between the terminal hydroxyl of a nucleotide and the hydroxyl of a serine or threonine residue of a peptide by a phosphodiester bond. This synthesis utilizes the phosphoramidite method with allyl for the
Akira Sakakura, Yoshihiro Hayakawa
openaire   +1 more source

ChemInform Abstract: A Novel Synthesis of Oligonucleotide—Peptide Conjugates with a Base‐Labile Phosphate Linker Between the Two Components According to the Allyl‐Protected Phosphoramidite Strategy.

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Akira Sakakura, Yoshihiro Hayakawa
openaire   +1 more source

Antibody drug conjugate: the “biological missile” for targeted cancer therapy

Signal Transduction and Targeted Therapy, 2022
Sifei Han, Chen Shi, Yu Zhang
exaly  

Click Nucleophilic Conjugate Additions to Activated Alkynes: Exploring Thiol-yne, Amino-yne, and Hydroxyl-yne Reactions from (Bio)Organic to Polymer Chemistry

Chemical Reviews, 2021
Joshua C Worch, Matthew J Price, Andrew Dove   +2 more
exaly  

Organic Synthesis and Antisense Effects of Oligonucleotide-Peptide Conjugates

Current Organic Chemistry, 2009
Satoshi Murao, Masayuki Fujii
openaire   +1 more source