Results 31 to 40 of about 261,560 (258)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Changes in plasma fatty acid composition in females with lipedema following low-carbohydrate vs low-fat diets and associations with pain reduction

Nutrition Journal
Background Lipedema is a chronic female disease characterized by a painful accumulation of adipose tissue in the limbs. Plasma fatty acid (FA) composition has been proposed as a potential modulator of pain.
Julianne Lundanes, Vilde Fiske Nes, Patrik Hansson, Rikard Fristedt, Rikard Landberg, Catia Martins, Siren Nymo   +6 more
doaj   +1 more source

The omega-6/omega-3 fatty acid ratio: health implications

Oléagineux, Corps gras, Lipides, 2010
Today, Western diets are characterized by a higher omega-6 and a lower omega-3 fatty acid intake, whereas during the Paleolithic period when human’s genetic profile was established, there was a balance between omega-6 and omega-3 fatty acids.
Simopoulos Artemis P.
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Relación de Ácidos grasos Omega 6 /Omega 3

Revista Digital de Postgrado, 2014
La relación de ácidos grasos (AG)ω6/ω3 de ladieta contemporánea favorece a los AG ω6. El objetivodel estudio fue evaluar el efecto de dietas concantidades crecientes de aceite de pescado (AcP),rico en AG ω3, sobre el crecimiento y las ...
Zury Dominguez
doaj  

Using 3–6 differences in essential fatty acids rather than 3/6 ratios gives useful food balance scores

Nutrition & Metabolism, 2012
Background The vitamin-like omega-3 and omega-6 essential fatty acids are converted in the body to a large family of hormones which act at selective receptors that occur on nearly every cell and tissue.
Lands Bill, Lamoreaux Etienne
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

PECES DULCEACUÍCOLAS COMO ALIMENTO FUNCIONAL: PERFIL DE ÁCIDOS GRASOS EN TILAPIA Y BOCACHICO CRIADOS EN POLICULTIVO PEIXES DE ÁGUA DOCE COMO UM ALIMENTO FUNCIONAL: PERFIL DE ÁCIDOS GRAXOS DE TILÁPIA E BOCACHICO EM POLICULTURA FRESHWATER FISH AS A FUNCTIONAL FOOD: FATTY ACID PROFILE IN POLYCULTURE OF TILAPIA AND BOCACHICO

Biotecnología en el Sector Agropecuario y Agroindustrial, 2012
Para evaluar el efecto de dos estrategias alimentarias y presencia de sustrato para perifiton sobre el perfil de ácidos grasos, características sensoriales y microbiológicas en filetes de tilapia y bocachico, se realizó un policultivo bajo un diseño ...
TATIANA ISABEL RESTREPO V., GONZALO JAIR DÍAZ G., SANDRA CLEMENCIA PARDO C.   +2 more
doaj