Results 61 to 70 of about 22,170 (231)

The effect of ethyl acetate extract from Atractylis flava Desf. on the gene expression of pro-inflammatory cytokines and oxidative stress markers in NR8383 alveolar rat macrophage cells

Current Issues in Pharmacy and Medical Sciences
Atractylis flava Desf. (AF) is common plant that is widely used for its anti- inflammatory and antioxidant properties. The purpose of this study was, therefore, to evaluate the cytotoxic effect and the molecular basis of antioxidant and anti-inflammatory
Melakhessou Mohamed Akram, Eddine Marref Salah, Zahra Doumandji, Ramia Safar, Marref Cherine, Imene Becheker, Olivier Joubert   +6 more
doaj   +1 more source

The Effect of 4 Weeks of Aerobic Training on Spatial Learning, Memory Performance and Mitochondrial Dynamics in the Hippocampal Tissue of Old Rats

Journal of Ardabil University of Medical Sciences, 2020
Background & objectives: Mitochondrial dysfunction is one of the main risk factors for neurological diseases which are associated with aging. On the other hand, aerobic exercise has beneficial effects on the brain health and cognitive function, and also ...
Ahmad Fazeli Sani, Hasan Matin homaee, Abdolali Banaeifar   +2 more
doaj  

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

OPA1 and cardiolipin team up for mitochondrial fusion [PDF]

Nature Cell Biology, 2017
Fusion between the inner membranes of two mitochondria requires the GTPase optic atrophy 1 (OPA1), but the molecular mechanism is poorly understood. A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome.
Liu, Raymond, Chan, David C.
openaire   +3 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control

Frontiers in Cell and Developmental Biology, 2020
Mitochondrial dysfunction contributes to cardiovascular disorders, especially post-infarction cardiac injury, through incompletely characterized mechanisms.
Ting Xin, Wei Lv, Dongmei Liu, Yongle Jing, Fang Hu   +4 more
doaj   +1 more source

Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates [PDF]

, 2018
In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing so ...
A Ames 3rd, A Genoux, A Olichon, A Olichon, A Van’t Veer, A Vazquez-Martin, A Volkenhoff, AA Zdebik, B Daum, B Thisse, BR Pinho, C Alexander, C Delettre, C Delettre, C Frezza, C Kozlowski, C Lo, D Faccenda, D Faccenda, D Faccenda, D Faccenda, DC Wallace, DI Shah, E Brustein, F Ivanes, F Peri, G Diez-Roux, GJ Lieschke, H Okawa, I Matic, I Matic, I Wittig, J Garcia-Bermudez, J Nakamura, JH Postlethwait, JJ Rahn, K Hejzlarova, KM Davies, L Formentini, L Formentini, L Saint-Amant, LC O’Brien, LGJ Nijtmans, M Bonora, M Campanella, M Campanella, M Okouchi, M Sanchez-Arago, M Sanchez-Arago, M Sanchez-Arago, M Veas-Perez de Tudela, M Westerfield, M Yoshida, MA Calvaruso, MH Madeira, MJ Birket, ML Concha, MW Fox, P Herbomel, PW Ingham, R Domenis, R Martin-Jimenez, S Aijaz, S Barbato, S DiMauro, S Hoppins, S Magdaleno, SA Schrier, SE Brockerhoff, TJ Wilson, V Lefebvre, VH Perry, W Rouslin, XG Luo   +73 more
core   +2 more sources

The OPA1 gene and optic neuropathy [PDF]

British Journal of Ophthalmology, 2003
Each genetic discovery will help to solve a small piece of the puzzle of optic nerve death The optic nerve head findings in autosomal dominant optic neuropathy (ADOA) are well described in the literature.1 These patients demonstrate optic nerve head pallor, cupping, peripapillary atrophy, and unusual grey crescents on the temporal portion of their ...
openaire   +1 more source

Heterozygous OPA1 mutations in Behr syndrome [PDF]

Brain, 2010
ARTICLE Sir, We read with interest the paper by Yu-Wai-Man et al. (2010) on patients with dominant optic atrophy-plus with OPA1 mutations, which follows on previous reports by the same group (Amati-Bonneau et al. , 2008; Hudson et al. , 2008), reporting the relatively high frequency (∼20%) and the large spectrum of extra-ocular neurological ...
C. Marelli, P. Amati-Bonneau, P. Reynier, V. Layet, A. Layet, G. Stevanin, E. Brissaud, D. Bonneau, A. Durr, A. Brice   +9 more
openaire   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source