Results 1 to 10 of about 29,291 (166)

Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone

Brain Sciences, 2022
Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2).
Martin A. Katzman, Matthew P. Katzman
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Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
A Bisetti, AJ Lawrence, Alice Y. W. Chang, AR Di Sebastiano, B Boutrel, B Boutrel, B Wang, BA Baldo, Beáta Á. Borsay, C Baimel, C Peyron, CM Kotz, CS Molnar, Csilla S. Molnár, CV Dayas, D Georgescu, D Sulzer, E Hirsch, E Hrabovszky, E Hrabovszky, Erik Hrabovszky, G Aston-Jones, G Martin, GC Harris, GC Harris, J Fadel, J Xia, JA Hollander, JJ Balcita-Pedicino, K Mukai, L de Lecea, László Herczeg, M Barrot, M Narita, NM Vittoz, NM Vittoz, Péter Gergely, R Fronczek, R Sharf, R Sharf, RM Chemelli, S Deurveilher, S Srinivasan, SL Borgland, SV Mahler, T Bullmann, T Nakamura, T Sakurai, TM Korotkova, TM Korotkova, XY Lu, Y Date, Z Liposits, Zsolt Liposits   +53 more
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Activity of putative orexin neurons during cataplexy

Molecular Brain, 2022
It is unclear why orexin-deficient animals, but not wild-type mice, show cataplexy. The current hypothesis predicts simultaneous excitation of cataplexy-inhibiting orexin neurons and cataplexy-inducing amygdala neurons.
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki   +7 more
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Evolution of Orexin Neuropeptide System: Structure and Function

Frontiers in Neuroscience, 2020
Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya, Takeshi Sakurai
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Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension

Scientific Reports, 2021
Brain orexin system hyperactivity contributes to neurogenic hypertension. We previously reported upregulated neuronal kinin B1 receptor (B1R) expression in hypertension.
Rohan Umesh Parekh, Acacia White, Korin E. Leffler, Vinicia C. Biancardi, Jeffrey B. Eells, Abdel A. Abdel-Rahman, Srinivas Sriramula   +6 more
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Common carp (Cyprinus carpio) orexin: Molecular identification, tissue expression, and the role of Orexin-A in glucose metabolism

Aquaculture Reports, 2020
Orexins are neuropeptides involved in energy homeostasis. In fish, the function of orexin-A in glucose metabolism is less reported. The present study aims to identify the potential role of orexin-A in the glucose absorption and metabolism in common carp.
Liping Yang, Shaoyang Zhi, Junyi Hu, Wenlei Zhang, Yuru Zhang, Chaobin Qin, Guokun Yang, Xiao Yan, Guoxing Nie   +8 more
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Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling. [PDF]

PLoS ONE, 2016
Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL). Sleep disturbance can negatively impact overall quality of life,
David E Kram, Stephanie M Krasnow, Peter R Levasseur, Xinxia Zhu, Linda C Stork, Daniel L Marks   +5 more
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Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice

Frontiers in Neuroscience, 2021
The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of histamine neurons is increased in patients with NT1, results on orexin-deficient mouse models ...
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Cristiano Bombardi, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli   +9 more
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The orexin system in the enteric nervous system of the bottlenose dolphin (Tursiops truncatus). [PDF]

PLoS ONE, 2014
This study provides a general approach to the presence and possible role of orexins and their receptors in the gut (three gastric chambers and intestine) of confined environment bottlenose dolphin.
Claudia Gatta, Finizia Russo, Maria Grazia Russolillo, Ettore Varricchio, Marina Paolucci, Luciana Castaldo, Carla Lucini, Paolo de Girolamo, Bruno Cozzi, Lucianna Maruccio   +9 more
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Orexin-a elevation in antipsychotic-treated compared to drug-free patients with schizophrenia: A medication effect independent of metabolic syndrome

Journal of the Formosan Medical Association, 2022
Background/Purpose: Orexin-A levels are reportedly increased in antipsychotic (APD)-treated patients with schizophrenia compared to healthy controls and have been associated with metabolic abnormalities.
Po-Yu Chen, Chin-Kuo Chang, Chun-Hsin Chen, Su-Chen Fang, Valeria Mondelli, Chih-Chiang Chiu, Mong-Liang Lu, Ling-Ling Hwang, Ming-Chyi Huang   +8 more
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