Results 21 to 30 of about 29,387 (258)

DEC2 modulates orexin expression and regulates sleep. [PDF]

, 2018
Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the familial natural short sleep behavioral trait.
Fu, Ying-Hui, Hirano, Arisa, Hsu, Pei-Ken, McMahon, Thomas, Ptáček, Louis J, Xing, Lijuan, Yamazaki, Maya, Zhang, Luoying   +7 more
core   +1 more source

Orexin, cardio-respiratory function and hypertension

Frontiers in Neuroscience, 2014
In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. 1) Orexin, cardiovascular function and hypertension.
Aihua eLi, Eugene E Nattie
doaj   +1 more source

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.

PLoS ONE, 2022
Acquired loss of hypothalamic orexin (hypocretin)-producing neurons causes the chronic sleep disorder narcolepsy-cataplexy. Orexin replacement therapy using orexin receptor agonists is expected as a mechanistic treatment for narcolepsy.
Hikari Yamamoto, Yasuyuki Nagumo, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yukiko Namekawa, Tsuyoshi Nemoto, Hiromu Tanaka, Genki Takahashi, Akihisa Tokuda, Tsuyoshi Saitoh, Hiroshi Nagase, Hiromasa Funato, Masashi Yanagisawa   +12 more
doaj   +1 more source

Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function [PDF]

, 2006
Following inducible expression in HEK293 cells, the human orexin-1 receptor was targeted to the cell surface but became internalized following exposure to the peptide agonist orexin A.
Canals Buj, M., Ellis, J., Milasta, S., Milligan, G., Pediani, J.D.   +4 more
core   +1 more source

Animals-assisted therapy: A brief review [PDF]

, 2018
In rehabilitative setting, the presence of animals can be considered as an important stimulus for verbal and social communication, and for mood regulation.
Cerroni F., Chisari M. G., D'Oro L., Di Folco A., Gallai B., Geraci D., Giugliano P., Lavano F., Lavano S. M., Magliulo R. M., Marotta R., Marsala G., Murabito P., Parisi L., Pennacchio S., Picciocchi E., Romano P., Ruberto M., Russo D., Salerno M., Sorrentino M., Testa D., Tripi G.   +22 more
core   +1 more source

Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs

European Journal of Histochemistry, 2009
The presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques.
C Dall’Aglio, L Pascucci, F Mercati, A Giontella, V Pedini, P Scocco, P Ceccarelli   +6 more
doaj   +1 more source

Involvement of orexinergic system in psychiatric and neurodegenerative disorders: A scoping review

Brain Circulation, 2020
Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex concerned in the wakefulness and excitement. This study aimed to review the possible neurobiological effect of orexin.
Hayder M Al-Kuraishy, May H Abdulhadi, Nawar R Hussien, Marwa S Al-Niemi, Huda A Rasheed, Ali I Al-Gareeb   +5 more
doaj   +1 more source

Orexin-A exerts equivocal role in atherosclerosis process depending on the duration of exposure : in vitro study [PDF]

, 2019
Orexin-A is a peptide hormone that plays a crucial role in feeding regulation and energy homeostasis. Diurnal intermittent fasting (DIF) has been found to increase orexin-A plasma levels during fasting hours, while Ramadan fasting which resembles DIF ...
Daskalopoulou, Aphrodite, Dimitriadis, Georgios K., Karapanagioti, Angeliki, Kassi, Eva, Lianidou, Evi, Nasiri Ansari, Narjes, Papavassiliou, Athanasios G., Randeva, Harpal S., Siasos, Gerasimos, Spentza, Flora   +9 more
core   +1 more source

Early detection of Niemann-pick disease type C with cataplexy and orexin levels: continuous observation with and without Miglustat

Orphanet Journal of Rare Diseases, 2020
Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi, T. Kawazoe, Y. Hamada, T. Kumagai, K. Tsutsui, N. Sakai, K. Eto, A. Noguchi, T. Shimizu, T. Takahashi, G. Han, K. Mishima, T. Kanbayashi, H. Kondo   +13 more
doaj   +1 more source

Reduced CSF orexin levels in rats and patients with systemic inflammation: a preliminary study

BMC Research Notes, 2022
Objective Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection.
Yasuhiro Ogawa, Nobutake Shimojo, Akiko Ishii, Akira Tamaoka, Satoru Kawano, Yoshiaki Inoue   +5 more
doaj   +1 more source