Results 61 to 70 of about 29,387 (258)

Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B [PDF]

Journal of Endocrinology, 2006
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body weight by interacting with a complex array of bioactive peptides; however, there are ...
J E, Digby, J, Chen, J Y, Tang, H, Lehnert, R N, Matthews, H S, Randeva   +5 more
openaire   +2 more sources

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive value [PDF]

, 2007
Neuronal activity regulated pentraxin (Narp) is a secreted neuronal product which clusters AMPA receptors and regulates excitatory synaptogenesis. Although Narp is selectively enriched in brain, its role in behavior is not known.
Baraban, Jay M, Crombag, Hans, Holland, Peter C, Huganir, Richard L, Johnson, Alexander W, Reti, Irving M, Takamiya, Kogo   +6 more
core   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

Orexin-A increases the differentiation of human olfactory sensory neurons through orexin receptor type 1

Regenerative Therapy
Introduction: Sensorineural olfactory dysfunction significantly impairs the life quality of patients but without effective treatments to date. Orexin is a neurotrophic factor activates neuronal network activity.
Yin-Tzu Chen, Tai-Horng Young, Yu-Hsin Wang, Chih-Hsuan Huang, Yu-Yun Gao, Tsung-Wei Huang   +5 more
doaj   +1 more source

The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats. [PDF]

, 2014
The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM.
Kilduff, Thomas S, Lincoln, Webster U, Morairty, Stephen R, Neylan, Thomas C, Wilk, Alan J   +4 more
core   +2 more sources

Orexin A ameliorates HBV X protein-induced cytotoxicity and inflammatory response in human hepatocytes

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hepatitis B virus is one of the main causes of hepatitis and hepatocellular carcinoma (HCC). Hepatitis B virus-encoded X protein (HBx) has been shown to be involved in many aspects of the pathogenicity of liver diseases.
Li Wang, Tao He, Baishun Wan, Xiaoqian Wang, Ling Zhang   +4 more
doaj   +1 more source

Pancreatic exocrine insufficiency after bariatric surgery [PDF]

, 2017
Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban, Haas, Stephan L., Löhr, J. -Matthias, Martin, Lena, Rutkowski, Wiktor, Thorell, Anders, Valente, Roberto, Vujasinovic, Miroslav   +7 more
core   +1 more source

Nucleophilic substitution of a phthalimidyl group with morpholine in an N1‐methyl‐1,2,3‐triazole: crystallographic evidence for migration of the methylene bridge

Acta Crystallographica Section C, EarlyView.
X‐ray crystallography revealed that the reaction of 2‐{[4‐(4‐bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide with morpholine led to substitution of the phthalimide group, including migration of the substituent from N1 to N2 on the 1,2,3‐triazole ring.2‐{[4‐(4‐Bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide, C17H11BrN4O, was synthesized by ...
Paul R. Palme, Richard Goddard, Markus Leutzsch, Adrian Richter, Peter Imming, Rüdiger W. Seidel   +5 more
wiley   +1 more source

Neural pathways from hypothalamic orexin neurons to the ventrolateral preoptic area mediate sleep impairments induced by conditioned fear

Frontiers in Neuroscience, 2023
IntroductionFear and sleep impairments common co-exist, but the underlying mechanisms remain unclear. Hypothalamic orexinergic neurons are involved in the regulation of sleep-wake and fear expression.
Caifen Ma, Caifen Ma, Ning Zhou, Kang Ma, Kang Ma, Jiandong Niu, Jiandong Niu, Ting Mi, Ting Mi, Zhenquan He, Yujun Wen, Yujun Wen, Chunhong Liu, Chunhong Liu, Zhongyi He, Jianguo Niu, Jianguo Niu   +16 more
doaj   +1 more source