Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation [PDF]
, 2010 Martins PJ, Marques MS, Tufik S, D'Almeida V. Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation. Am J Physiol Endocrinol Metab 298: E726-E734, 2010.
D'Almeida, Vania +3 more
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Children with Narcolepsy type 1 have increased T‐cell responses to orexins
Annals of Clinical and Translational Neurology, 2019 Narcolepsy type 1 (NT1) is caused by severe loss of the orexin neurons, and is highly associated with HLA DQB1*06:02. Using intracellular cytokine staining, we observed a higher frequency of IFN‐γ‐ and TNF‐α‐producing CD4+ and CD8+ T‐cells in response to
Andrew C. Cogswell +5 more
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Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone
Brain Sciences, 2022 Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2).
Martin A. Katzman, Matthew P. Katzman
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Expression of Orexin A and its Receptor 1 in the Epididymis of the South American Camelid Alpaca (Vicugna pacos). [PDF]
, 2013 Orexins A (ox A) and B are two peptides originally discovered in neurons of rat hypothalamus, and later found in different cellular types of the gastrointestinal and genital tracts. They arise from the proteolytic cleavage of a common precursor molecule,
DE LUCA, ADRIANA +5 more
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Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]
, 2015 No abstract ...
Alvarez-Curto, Elisa +4 more
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Frontiers in Endocrinology, 2013 The hypothalamus monitors body homeostasis and regulates various behaviors such as feeding, thermogenesis, and sleeping. Orexins (also known as hypocretins) were identified as endogenous ligands for two orphan G-protein-coupled receptors in the lateral ...
Ayumu eInutsuka +3 more
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Orexin in the chicken hypothalamus: immunocytochemical localisation and comparison of mRNA concentrations during the day and night, and after chronic food restriction [PDF]
, 2013 In mammals Orexin-A and -B are neuropeptides involved in the hypothalamic regulation of diverse physiological functions including food intake and the sleep-wake cycle.
de Girolamo, Paolo +5 more
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Frontiers in Endocrinology, 2018 Orexins (OxA and OxB) also termed hypocretins are hypothalamic neuropeptides involved in central nervous system (CNS) to control the sleep/wake process which is mediated by two G protein-coupled receptor subtypes, OX1R, and OX2R.
Alain Couvineau +6 more
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Expression and potential role of the peptide orexin-A in prostate cancer [PDF]
, 2015 The peptides orexin-A and orexin-B and their G protein-coupled OX1 and OX2 receptors are involved in multiple physiological processes in the central nervous system and peripheral organs.
ASSISI, LOREDANA +11 more
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Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. [PDF]
, 2014 Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning.
Longordo, F. +4 more
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