Results 151 to 160 of about 55,714 (303)

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, EarlyView.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Effect of aging on healing of mandibular tooth extraction socket in a rat model

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated the effect of aging on bone regeneration in mandibular extraction sockets. Male Sprague–Dawley rats were divided into three age groups: 2‐month‐old (2 M, n = 6), 10‐month‐old (10 M, n = 6), and 18‐month‐old (18 M, n = 5). Two weeks post‐extraction, comprehensive analyses were performed using micro‐computed tomography (µ‐CT)
Kyung Su Shin, Han Wool Kwak, Jong‐Seong Chae, Si‐On Choi, Suah Han, Hwa Young Yu, Dae Ho Leem, Hyun Seok   +7 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Traumatic Occlusion Exacerbates Bone Resorption by Modifying Gene Expression in the Bone Tissue of Ligature‐Induced Periodontitis in Mice

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To clarify the molecular mechanisms of occlusal trauma in bone loss through periodontal tissue transcriptome analysis in mice with periodontitis and traumatic occlusion. Materials and Methods Ligature‐induced periodontitis (Li) and composite resin‐induced traumatic occlusion (Tra) mouse models were established (control [Co], Li, Tra and ...
Yosuke Tsuchiya, Yujin Ohsugi, Tomomitsu Hirota, Yohei Hayashi, Peiya Lin, Yuta Tsukahara, Takanori Iwata, Sayaka Katagiri   +7 more
wiley   +1 more source

The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration—Part I: Human Histologic Evaluation of 20 Consecutive Cases

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To histologically evaluate the healing of intrabony periodontal defects treated with guided tissue regeneration (GTR), if it is combined with orthodontic tooth movement (OTM) or used as a sole treatment. Materials and Methods Twenty subjects requiring regenerative periodontal therapy and OTM were treated with the use of extended, coronally
Pal Nagy, Peter Windisch, Balint Nemes, Peter Schupbach, Andrea Dobos, Andreas Stavropoulos   +5 more
wiley   +1 more source

Osteocyte [PDF]

, 2020
openaire   +1 more source

Slow‐Resorbing Small Intestinal Submucosa Membrane for Horizontal Ridge Augmentation: A Case Series

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective To evaluate the efficacy of a slow‐resorbing small intestinal submucosa (SIS) membrane combined with freeze‐dried bone allograft (FDBA) for horizontal bone augmentation in severely atrophic ridges. Materials and Methods Six patients underwent horizontal ridge augmentation using FDBA and a slow‐resorbing SIS membrane.
Mingxu Sun, Zhaozhao Chen, Zhen Yang, Chongxia Yue, Xingwang Liu, Hom‐Lay Wang   +5 more
wiley   +1 more source

Clinical, Radiographic, and Histopathologic Features of Human Perigraftitis

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective Perigraftitis is a biologic complication associated with dental implants placed in grafted bone, distinct from peri‐implant mucositis and peri‐implantitis. This report further characterizes its clinical, radiographic, and histopathologic features.
Jonathan H. Do, Charles M. Cobb, John T. Shen   +2 more
wiley   +1 more source