Results 61 to 70 of about 31,786 (255)

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Promoting effect of 1,25(OH)2 vitamin D3 in osteogenic differentiation from induced pluripotent stem cells to osteocyte-like cells [PDF]

Open Biology, 2015
We recently reported a new method to purify the induced pluripotent stem (iPS)-derived osteoprogenitors (iPSop). In this paper, we optimized the procedure and characterized cells at each process step. We observed that 10 days of treatment with FGF-2, IGF-
Hiroshi Kato, Hiromi Ochiai-Shino, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma   +5 more
doaj   +1 more source

The Effect of Osteocyte Signalling on Osteocyte Apoptosis [PDF]

Proceedings of Surabaya International Physiology Seminar, 2017
Abstract: Background: Physical exercise has been known that is one of the ways to evoke mechanical stimulation that can cause the change of the “strain”. The “strain” itself allows the converted mechanical signal to be a biochemistry that can produce a biological response to bone cells.
Dwi Setiani Sumardiko, Purwo Sri Rejeki, Gadis Meinar Sari   +2 more
openaire   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Mechanical Loading Induces NRF2 Nuclear Translocation to Epigenetically Remodel Oxidative Stress Defense in Osteocytes

Antioxidants
The mechano-responsiveness of osteocytes is critical for maintaining bone health and associated with a reduced oxidative stress defense, yet the precise molecular mechanisms remain incompletely understood.
Yue Guo, Jing Zhang, Luyu Gong, Na Liu, Qiaoqiao Liu, Zhaojun Liu, Baosheng Guo, Jingping Yang   +7 more
doaj   +1 more source

The Osteocyte: New Insights

Annual Review of Physiology, 2020
Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the osteocyte is perhaps among the least studied cells in all of vertebrate biology.
Robling, Alexander G., Bonewald, Lynda F.   +1 more
openaire   +3 more sources

Glucocorticoids and osteocyte autophagy [PDF]

Bone, 2013
Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases. While they are effective therapy, bone loss and incident fracture risk are high. While previous studies have found GC effects on both osteoclasts and osteoblasts, our work has focused on the effects of GCs on osteocytes.
Wei, Yao, Weiwei, Dai, Jean X, Jiang, Nancy E, Lane   +3 more
openaire   +2 more sources

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Immunomodulatory and Regenerative Functions of MSC-Derived Exosomes in Bone Repair

Bioengineering
Bone integrity is maintained through continuous remodeling, orchestrated by the coordinated actions of osteocytes, osteoblasts, and osteoclasts. Once considered passive bystanders, osteocytes are now recognized as central regulators of this process ...
Manorathna Arun, Sheeja Rajasingh, Parani Madasamy, Johnson Rajasingh   +3 more
doaj   +1 more source

Osteocyte control of osteoclastogenesis [PDF]

Bone, 2013
Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine
Charles A, O'Brien, Tomoki, Nakashima, Hiroshi, Takayanagi   +2 more
openaire   +2 more sources