Results 91 to 100 of about 4,866 (174)

First Report of OXA-181-Producing Klebsiella pneumoniae in China

Infection and Drug Resistance, 2020
Congcong Liu,1 Yinfei Fang,2 Yu Zeng,1 Jiayue Lu,1 Qiaoling Sun,1 Hongwei Zhou,1 Zhangqi Shen,3 Gongxiang Chen1 1Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang, Hangzhou, People’s ...
Liu C, Fang Y, Zeng Y, Lu J, Sun Q, Zhou H, Shen Z, Chen G   +7 more
doaj  

Emergence and dissemination of multidrug-resistant Escherichia coli ST8346 coharboring blaNDM-5 and blaOXA-181 in Southern Taiwan, 2017–2021

Journal of Infection and Public Health, 2023
Background: Enterobacterales carrying blaNDM represent an emerging challenge in treating infectious diseases. In this study, we aimed to investigate the characteristics of blaNDM-producing Enterobacterales from three hospitals in southern Taiwan. Methods:
Chia-Hung Tsai, Nan-Yao Lee, Chien-Ming Chao, Chi-Chung Chen, Chih-Cheng Lai, Chung-Han Ho, Yu-Chin Chen, Po-Yu Chen, Hung-Jen Tang, Hung-Jui Chen, Bo-An Su, Hsin-Yu Lai, Julie Chi Chow, Tu-Hsuan Chang   +13 more
doaj   +1 more source

Expansion of KPC-producing klebsiella pneumoniae with various mgrB-mutations giving rise to colistin-resistance:the role of ISL3 on plasmids [PDF]

, 2018
BACKGROUND: mcr-1 has been reported as first plasmid gene to confer colistin-resistance. In KPC-producing Klebsiella pneumoniae (KPC-KP) isolates, however, colistin resistance is rapidly emerging through other mechanisms. This is frequently the result of
Barnini, Simona, Bathoorn, Erik, Chlebowicz, Monika A, Friedrich, Alexander W, Gikas, Achilleas, Giordano, Cesira, Rossen, John W, Scoulica, Effie V, Tsioutis, Constantinos   +8 more
core   +1 more source

Whole-genome sequencing enables molecular characterization of non-clonal group 258 high-risk clones (ST13, ST17, ST147 and ST307) among Carbapenem-resistant Klebsiella pneumoniae from a tertiary university hospital centre in Portugal [PDF]

, 2022
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The carbapenem ...
Bruschy Fonseca, Ana, Caneiras, Catia, Cristino, José Melo, Duarte, Aida, Lito, Luís, Mendes, Gabriel, Ramalho, João Francisco   +6 more
core   +1 more source

Advances in Double‐Stranded DNA Targeting Technologies

Exploration, Volume 6, Issue 1, February 2026.
Double‐stranded DNA (dsDNA) plays a crucial role in genetic information storage and disease management, but its inherent stability limits access to internal bases. To overcome this challenge, various high‐specificity molecular targeting technologies have been developed to destabilize the DNA structure.
Zuhao Shen, Yiqun Liu, Yingjie Hao, Yifan Bo, Xiaochuan Dai, Shihui Wang, Tian Xia, Xin Su, Huiyu Liu   +8 more
wiley   +1 more source

The First Report of Escherichia coli and Klebsiella pneumoniae Strains That Produce Both NDM-5 and OXA-181 in Jiangsu Province, China

Infection and Drug Resistance, 2023
Guixiang Tao,1,* Hua Tan,2,* Qian Chen1 1Institute of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Clinical Laboratory, Children’s Hospital of Nanjing Medical University ...
Tao G, Tan H, Chen Q
doaj  

Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]

, 2015
Objectives: Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum ...
Nordmann, Patrice, Oueslati, Saoussen, Poirel, Laurent   +2 more
core  

Sequencing of blaIMP-Carrying IncN2 Plasmids, and Comparative Genomics of IncN2 Plasmids Harboring Class 1 Integrons [PDF]

, 2017
This work presents the complete nucleotide sequences of p0801-IMP from Klebsiella pneumoniae, p7121-IMP from K. oxytoca, and p17285-IMP from Citrobacter freundii, which are recovered from three different cases of nosocomial infection.
Defu Zhang, Dongsheng Zhou, Haihong Fang, Jiao Feng, Jinglin Wang, Qiang Sun, Shuiping Chen, Weijun Chen, Xiaoyuan Jiang, Xiuyun Yin, Yajun Song, Yigang Tong, Yuanhong Xu, Zhe Yin   +13 more
core   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

OXA-48-like carbapenemases in Proteus mirabilis – novel genetic environments and a challenge for detection

Emerging Microbes and Infections
OXA-48-like enzymes represent the most frequently detected carbapenemases in Enterobacterales in Western Europe, North Africa and the Middle East. In contrast to other species, the presence of OXA-48-like in Proteus mirabilis leads to an unusually ...
Janko Sattler, Janina Noster, Yvonne Stelzer, Martina Spille, Sina Schäfer, Kyriaki Xanthopoulou, Julian Sommer, Jonathan Jantsch, Silke Peter, Stephan Göttig, Sören G. Gatermann, Axel Hamprecht   +11 more
doaj   +1 more source