Results 121 to 130 of about 3,195 (172)

Clin Infect Dis [PDF]

The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern.

core  

Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance
BACKGROUND-AIM: Although ceftazidime/avibactam is the agent of choice in OXA-48-producing Klebsiella pneumoniae infections, it is not readily available or prohibitively expensive in many countries. Since piperacillin/tazobactam plus meropenem combination
Abdullah Tarik Aslan, Mervenur Demir, Elif Seren Tanriverdi, Budi Permana, Rhys Izuagbe, Kay A. Ramsay, Brian Forde, Baris Otlu, David L. Paterson, Patrick Harris, Murat Akova, Gulsen Hazirolan   +11 more
doaj   +1 more source

Clinical evaluation of advanced MALDI-TOF MS for carbapenemase subtyping in Gram-negative isolates

Journal of Clinical Microbiology
The spread of carbapenemase-producing Enterobacterales (CPE) is emerging as a significant clinical concern in tertiary hospitals and, in particular, long-term care facilities with deficiencies in infection control. This study aims to evaluate an advanced
Dong Huey Cheon, Heejung Jang, Yoon Kyung Choi, Won Seok Oh, Seohyun Hwang, Ju-Ri Park, Hyojin Kim, Yoonha Park, Saeyoung Lee, Won Suk Yang, Min Jin Kim, Sun Hwa Lee, Je-Hyun Baek   +12 more
doaj   +1 more source

Assessment of Phenotypic Tools for Detection of OXA-48, KPC, and NDM in Klebsiella pneumoniae in Oman

Diagnostics
Background: The alarming increase in carbapenemase-producing Enterobacterales is a matter of grave public health concern. The most ubiquitous carbapenemases, Klebsiella pneumoniae carbapenemase (KPC)-, New Delhi metallo-β-lactamase (NDM)-, and ...
Arwa AL Rujaibi, Zaaima AL Jabri, Amina Al Jardani, Azza AL Rashdi, Azza AL Mamari, Sara AL Sumri, Hiba Sami, Zakariya Al Muharrmi, Meher Rizvi   +8 more
doaj   +1 more source

Resistance, Virulence, and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Causing Bloodstream Infections in Saudi Arabia

Microorganisms
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a major cause of bloodstream infections and poses serious challenges to clinical management because treatment options are limited.
Fetoon M. Alkhelaiwi, Ali M. Somily, Reham M. Alahmadi, Maaweya Awadalla, Ahmed M. Albarrag, Bandar Alosaimi, Eman Marzouk, Ihab M. Moussa   +7 more
doaj   +1 more source

Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant bla_OXA-232-Carrying Klebsiella pneumoniae Sequence Type 15 Lineage. [PDF]

Emerg Infect Dis, 2023
Wu Y, Jiang T, He X, Shao J, Wu C, Mao W, Jia H, He F, Kong Y, Wu J, Sun Q, Sun L, Draz MS, Xie X, Zhang J, Ruan Z.   +15 more
europepmc   +1 more source

The Microbiological Characteristics and Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Clinical Samples

Microorganisms
Klebsiella pneumoniae is a major public health concern due to its role in Gram-negative bacteremia, which leads to high mortality and increased healthcare costs. This study characterizes phenotypic and genomic features of K.
Mehwish Rizvi, Noman Khan, Ambreen Fatima, Rabia Bushra, Ale Zehra, Farah Saeed, Khitab Gul   +6 more
doaj   +1 more source

Evaluation of the RAPIDEC® CARBA NP, the Rapid CARB Screen® and the Carba NP test for biochemical detection of carbapenemase-producing Enterobacteriaceae [PDF]

, 2017
Objectives The objective of this study was the evaluation of the performance of two commercially available biochemical tests for the rapid detection of carbapenemase-producing Enterobacteriaceae compared with a home-made technique.
Agathine, Aurélie, Cuzon, Gaëlle, Dortet, Laurent, Naas, Thierry, Nordmann, Patrice, Poirel, Laurent   +5 more
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Search and contain : impact of an integrated genomic and epidemiological surveillance and response program for control of carbapenemase-producing Enterobacterales [PDF]

Funding: This work was supported by the National Health and Medical Research Council through a partnership grant (grant number GNT1149991) and individual supporting grants (grant numbers GNT1142613 [to J. C. K.], GNT1123854 [to D. A.
Ballard, Susan A., Brett, Judith, Cameron, Donna R.M., Cheng, Allen C., Easton, Marion, Goncalves Da Silva, Anders, Gorrie, Claire L., Howden, Benjamin P., Kwong, Jason C., Lane, Courtney R., Peleg, Anton Y., Romanes, Finn, Sait, Michelle, Schultz, Mark, Seemann, Torsten, Sherry, Norelle L., Spelman, Denis W., St George, Siobhan, Stephens, Nicola, Stevens, Kerrie, Stewardson, Andrew J., Stuart, Rhonda L., Sutton, Brett, Van Diemen, Annaliese, Waters, Mary Jo, Williamson, Deborah A.   +25 more
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THE ROLE OF PLASMIDS AND CLONES IN THE EMERGENCE OF CARBAPENEM RESISTANT ENTEROBACTERIACEAE IN THE UNITED ARAB EMIRATES [PDF]

, 2019
Resistance to carbapenems, the ultimate beta-lactam antibiotics used to treat life-threatening Gram-negative infections associates with very high mortality.
Mouftah Ali, Shaimaa Fekry Mahmoud
core   +1 more source