Results 61 to 70 of about 31,782 (306)

Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives

Molecules, 2011
Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira, Nagwa Mohamed Mahrous Hamada   +1 more
doaj   +1 more source

Synthesis of Some 1,4-Bis (Substituted 1,3,4-Oxadiazoles and 1,2,4-Triazoles) Benzene From Terephthalic Acid [PDF]

مجلة التربية والعلم, 1999
In this paper the synthesis of some 1,4-bis-(substituted1,3,4-oxadiazoles and 1,2,4-trizoles) benzene from terephthalic acid is reported. Terephthalic acid was esterified with absolute ethanol in presence of concentrated sulfuric acid to give ethyl ...
K. Daoud, E. Mahmood, M. Salih
doaj   +1 more source

Bifunctional monomers having terminal oxime and cyano or amidine groups [PDF]

, 1981
The preparation of crosslinked 1,2,4-oxadiazole elastomers is described. The technique involves thermally condensing (1) a monomer having the formula H2N(HON)C-R-Q, wherein Q is a triazine ring-forming groups such as nitrile or amidine or a mixture of ...
Kwongs, H., Rosser, R. W., Shalhoub, I. M.   +2 more
core   +1 more source

A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [PDF]

, 2010
Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids.
Lamani, R.S., Nagendra, G., Narendra, N., Sureshbabu, V.V.   +3 more
core   +1 more source

Synthesis of 1,2,4-Oxadiazoles by Tandem Reaction of Nitroalkenes with Arenes and Nitriles in the Superacid TfOH.

Journal of Organic Chemistry, 2019
The tandem reaction of nitroalkenes with arenes and nitriles in the superacid CF3SO3H (TfOH) results in the formation of 1,2,4-oxadiazole derivatives in yields up to 96%.
Andrei A Golushko, O. Khoroshilova, A. Vasilyev   +2 more
semanticscholar   +1 more source

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90 [PDF]

, 2010
The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm ...
A Hoerauf, A Kamal, A Rodina, AA Sayed, Anna Rodina, BA Sheehy, C Bourguinat, C Gloeckner, CL David, D Addiss, DF Cully, DH Molyneux, E Caldas-Lopes, E Devaney, E Ghedin, Eileen Devaney, F Aguero, G Chiosis, Gabriela Chiosis, H He, JA Dent, JA Frearson, JA Frearson, JE Day, JH Zhang, K Moulick, Kerry O'Neill, Kirsty Maitland, L Neckers, L Neckers, L Timmons, LE Cowen, M Peroval, M Vilenchik, Matty Knight, N Kato, NA Him, P Workman, Pallav Patel, PJ Hotez, PW Piper, R Kumar, RE Howells, RI Hewitt, RK Allan, S Kumar, S Nwaka, SN Chen, SN Shelton, T Stiernagle, T Supali, T Taldone, T Taldone, T Taldone, TG Geary, Tony Taldone, V Gillan, Victoria Gillan, W Grant, W Luo, Weilin Sun, Y Du   +61 more
core   +9 more sources

Electrocyclic Ring‐Opening of 1,2,4‐Oxadiazole[4,5‐a]piridinium Chloride: a New Route to 1,2,4‐Oxadiazole Dienamino Compounds

ChemistryOpen, 2019
1,2,4‐Oxadiazole[4,5‐a]piridinium chloride adds nucleophiles to undergo electrocyclic ring opening affording 1,2,4‐oxadiazole dienamino derivatives. These pyridinium salts represent a special class of Zincke salts that are prone to rearrange when treated
Dr. Stefano Carella, Dr. Misal Giuseppe Memeo, Prof. Paolo Quadrelli   +2 more
doaj   +1 more source

Preparation of crosslinked 1,2,4-oxadiazole polymer [PDF]

, 1981
New crosslinked 1,2,4-oxadiazole elastomers were prepared by thermally condensing a monomer having the formula H2N(HON)C-R-Q, wherein Q is a triazine ring-forming group such as nitrile or amidine or a mixture of such group with amidoxime, or a mixture of
Kwong, H., Rosser, R. W., Shalhoub, I. M.   +2 more
core   +1 more source

Recovery of Liquid Organic Radioactive Waste Absorbed Into Soil by Extraction

CleanMat, EarlyView.
Radioactive organic liquid waste adsorbed in soil containing pure beta‐emitting radionuclides such as H‐3 must be radiologically characterized for subsequent management. For this purpose, a method for the recovery of radioactive scintillation liquids adsorbed in soil has been developed that simulates this type of waste.
Fabiola Monroy‐Guzman, Yurihelem Jacobo Cruz, Thelma Selene Jiménez Bravo, Ignacio Alfredo Rivero Espejel, Jorge Anguiano Arévalo, María Dolores Tenorio Castillejos   +5 more
wiley   +1 more source