Results 61 to 70 of about 32,424 (300)

Synthesis of New Three-Component Derivatives of 1, 3, 4-Oxadiazole and Evaluation of Their In Vitro Antibacterial and Antifungal Properties

Medical Laboratory Journal, 2021
Background and objectives: Antibiotic resistance is a major public health challenge. The pervasive antibiotic misuse can lead to increased antibiotic resistance.
Nakisa Zarrabi Ahrabi, Ali souldozi, Yasin SarveAhrabi   +2 more
doaj  

Bifunctional monomers having terminal oxime and cyano or amidine groups [PDF]

, 1981
The preparation of crosslinked 1,2,4-oxadiazole elastomers is described. The technique involves thermally condensing (1) a monomer having the formula H2N(HON)C-R-Q, wherein Q is a triazine ring-forming groups such as nitrile or amidine or a mixture of ...
Kwongs, H., Rosser, R. W., Shalhoub, I. M.   +2 more
core   +1 more source

A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [PDF]

, 2010
Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids.
Lamani, R.S., Nagendra, G., Narendra, N., Sureshbabu, V.V.   +3 more
core   +1 more source

Characterization of Structure, Properties, and Energetic Performance of a 1:1 Ammonium Dinitramide‐3,4‐Diaminofurazan Cocrystal

Propellants, Explosives, Pyrotechnics, EarlyView.
Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz, Uwe Schaller, Thomas Heintz   +2 more
wiley   +1 more source

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90 [PDF]

, 2010
The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm ...
A Hoerauf, A Kamal, A Rodina, AA Sayed, Anna Rodina, BA Sheehy, C Bourguinat, C Gloeckner, CL David, D Addiss, DF Cully, DH Molyneux, E Caldas-Lopes, E Devaney, E Ghedin, Eileen Devaney, F Aguero, G Chiosis, Gabriela Chiosis, H He, JA Dent, JA Frearson, JA Frearson, JE Day, JH Zhang, K Moulick, Kerry O'Neill, Kirsty Maitland, L Neckers, L Neckers, L Timmons, LE Cowen, M Peroval, M Vilenchik, Matty Knight, N Kato, NA Him, P Workman, Pallav Patel, PJ Hotez, PW Piper, R Kumar, RE Howells, RI Hewitt, RK Allan, S Kumar, S Nwaka, SN Chen, SN Shelton, T Stiernagle, T Supali, T Taldone, T Taldone, T Taldone, TG Geary, Tony Taldone, V Gillan, Victoria Gillan, W Grant, W Luo, Weilin Sun, Y Du   +61 more
core   +9 more sources

Design and Synthesis of New Boron-Based Benzo[c][1,2,5]oxadiazoles and Benzo[c][1,2,5]thiadiazoles as Potential Hypoxia Inhibitors

Inorganics, 2023
Benzo[c][1,2,5]oxadiazoles and benzo[c][1,2,5]thiadiazoles are recognized to possess potent pharmacological activities including anticancer potential. In continuation of our research endeavors in the development of boron-based heterocycles as potential ...
Sasmita Das, Mohammed Adil Shareef, Bhaskar C. Das   +2 more
doaj   +1 more source

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction

Organic Letters, 2019
Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was ...
Qian Wang, Kumchok C Mgimpatsang, M. Konstantinidou, S. Shishkina, A. Dömling   +4 more
semanticscholar   +1 more source

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Beyond the stop: Oxadiazole TRIDs restore LRBA protein expression in nonsense-driven primary immunodeficiency

Molecular Therapy: Nucleic Acids
Nonsense mutations are among the genetic causes of LRBA (lipopolysaccharide-responsive beige-like anchor) deficiency, a rare autosomal-recessive immunodeficiency disorder.
Ignazio Fiduccia, Emanuele Vitale, Riccardo Varrica, Davide Ricci, Sefora Marino, Antonino Zito, Andrea Pace, Alain Colige, Michel Moutschen, Yasmin Borutzki, Andrea Bileck, Samuel M. Meier-Menches, Laura Lentini, Ivana Pibiri   +13 more
doaj   +1 more source

A Useful Synthesis of 2-Acylamino-1,3,4-oxadiazoles from Acylthiosemicarbazides Using Potassium Iodate and the Discovery of New Antibacterial Compounds

Molecules, 2019
A useful method for the synthesis of 2-acylamino-1,3,4-oxadiazoles was developed. By using potassium iodate as an oxidant in water at 60 °C, a wide range of 2-acylamino-1,3,4-oxadiazoles were afforded in moderate to excellent yields within two hours.
Tianlei Li, Gang Wen, Jishun Li, Wenxuan Zhang, Song Wu   +4 more
doaj   +1 more source