Results 71 to 80 of about 5,687 (109)
Some of the next articles are maybe not open access.
Drugs, 2000
The oxazolidinones represent a novel chemical class of synthetic antimicrobial agents. They exhibit an unique mechanism of protein synthesis inhibition and generally display bacteriostatic activity against many important human pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin- and ...
D I, Diekema, R N, Jones
openaire +2 more sources
The oxazolidinones represent a novel chemical class of synthetic antimicrobial agents. They exhibit an unique mechanism of protein synthesis inhibition and generally display bacteriostatic activity against many important human pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and penicillin- and ...
D I, Diekema, R N, Jones
openaire +2 more sources
The Lancet, 2001
Many common gram-positive pathogens (eg, Staphylococcus aureus, Enterococcus spp, and Streptococcus pneumoniae) have become increasingly resistant to antimicrobial agents, and new drugs with activity against gram-positive bacteria are urgently needed. The oxazolidinones, a new chemical class of synthetic antimicrobial agent, have a unique mechanism of ...
D J, Diekema, R N, Jones
openaire +2 more sources
Many common gram-positive pathogens (eg, Staphylococcus aureus, Enterococcus spp, and Streptococcus pneumoniae) have become increasingly resistant to antimicrobial agents, and new drugs with activity against gram-positive bacteria are urgently needed. The oxazolidinones, a new chemical class of synthetic antimicrobial agent, have a unique mechanism of ...
D J, Diekema, R N, Jones
openaire +2 more sources
Acta Crystallographica Section C Crystal Structure Communications, 1997
Redetermination of the crystal structure of the title compound, C3H5NO2, leads to a precise geometry for this molecule that is compared with the conformation of several aryl-substituted oxazolidinones. Molecular cohesion is stabilized by hydrogen bonds between the amine and carbonyl groups.
Wouters, Johan +2 more
openaire +2 more sources
Redetermination of the crystal structure of the title compound, C3H5NO2, leads to a precise geometry for this molecule that is compared with the conformation of several aryl-substituted oxazolidinones. Molecular cohesion is stabilized by hydrogen bonds between the amine and carbonyl groups.
Wouters, Johan +2 more
openaire +2 more sources
Current Opinion in Microbiology, 2007
Due to the emergence of resistance to known antibiotics to various organisms, for example, Staphylococcus, Streptococcus, Enterococci, and Pseudomonas there is a renewed interest in the discovery of new antibacterials. Oxazolidinones, totally synthetic class of novel antibacterials, possess activity against drug-resistant Gram-positive pathogens ...
openaire +2 more sources
Due to the emergence of resistance to known antibiotics to various organisms, for example, Staphylococcus, Streptococcus, Enterococci, and Pseudomonas there is a renewed interest in the discovery of new antibacterials. Oxazolidinones, totally synthetic class of novel antibacterials, possess activity against drug-resistant Gram-positive pathogens ...
openaire +2 more sources
Current Infectious Disease Reports, 2002
The need for effective antibiotics to manage the ever increasing frequency of antibiotic-resistant gram-positive infections in much of the developed world has led to the clinical development of the first oxazolidinone antibiotic, linezolid. Linezolid possesses bacteriostatic activity against both antibiotic-susceptible and resistant strains of ...
openaire +2 more sources
The need for effective antibiotics to manage the ever increasing frequency of antibiotic-resistant gram-positive infections in much of the developed world has led to the clinical development of the first oxazolidinone antibiotic, linezolid. Linezolid possesses bacteriostatic activity against both antibiotic-susceptible and resistant strains of ...
openaire +2 more sources
Oxazolidinones: New antibacterial agents
Trends in Microbiology, 1997The oxazolidinones are a new chemical class of synthetic antibacterial agents that are active orally or intravenously against multidrug-resistant Gram-positive bacteria. Their unique mechanism of action and activity against bacteria that pose therapeutic problems in hospital and community treatments make them promising candidates for antimicrobial ...
C W, Ford +6 more
openaire +2 more sources
Acta Crystallographica Section C Crystal Structure Communications, 1998
The structures of two substituted oxazolidinones, namely, 4-hydroxymethyl-4-methyloxazolidin-2-one [C5H9NO3, (1)] and 4-ethyl-4-hydroxymethyloxazolidin-2-one [C6H11NO3, (2)], are reported. Bond distances in the two structures are almost identical. The oxazolidinone rings both adopt envelope conformations; the fold in (1) is significantly larger than ...
M. W. Eknoian +4 more
openaire +1 more source
The structures of two substituted oxazolidinones, namely, 4-hydroxymethyl-4-methyloxazolidin-2-one [C5H9NO3, (1)] and 4-ethyl-4-hydroxymethyloxazolidin-2-one [C6H11NO3, (2)], are reported. Bond distances in the two structures are almost identical. The oxazolidinone rings both adopt envelope conformations; the fold in (1) is significantly larger than ...
M. W. Eknoian +4 more
openaire +1 more source
Novel piperidinyloxy oxazolidinone antimicrobial agents
Bioorganic & Medicinal Chemistry Letters, 2001Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety, were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms.
M A, Weidner-Wells +6 more
openaire +2 more sources
Oxazolidinone-Promoted, Torquoselective Nazarov Cyclizations
Organic Letters, 2012Oxazolidinones are powerful promoters of the Nazarov reaction, enabling the cyclization of conventionally resistant substrates to be achieved under mild conditions. They exert excellent regio- and torquoselective control in both the conventional Nazarov reaction giving cyclopentenones and in the "interrupted" Nazarov reaction, giving more highly ...
Daniel J, Kerr +4 more
openaire +2 more sources
Tedizolid: A new oxazolidinone antimicrobial
American Journal of Health-System Pharmacy, 2014The mechanism of action, pharmacokinetics, pharmacodynamics, and clinical efficacy and safety of an investigational second-generation oxazolidinone are reviewed.Tedizolid is a protein synthesis inhibitor in clinical development for the treatment of gram-positive infections.
Kisgen, Jamie J. +3 more
openaire +3 more sources