Results 141 to 150 of about 11,306,965 (261)
Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease
Clinical Genetics, EarlyView.Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler +5 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyDuring the recent avian influenza epizootics that occurred in France in 2020/21 and 2021/22, the virus was so contagiousness that it was impossible to control its spread between farms.
Guillaume Croville +6 more
doaj +1 more source
Post‐Hoc Long‐Read Sequencing Links Leukemic Mutation Status to Single‐Cell Transcriptomes
European Journal of Haematology, EarlyView.ABSTRACT Single‐cell RNA‐sequencing‐based characterization of cells that belong to the neoplastic clone is a major challenge in hematologic neoplasms, where malignant and normal cells coexist. Confident molecular profiling requires simultaneous analysis of gene expression and genetic mutations in individual cells, an ability that is not supported by ...
Sofia Papavasileiou +8 more
wiley +1 more source
Equine Veterinary Education, EarlyView.Summary Erysipelothrix rhusiopathiae was the causative agent of vegetative endocarditis and vertebral osteomyelitis in a 24‐year‐old Irish draught gelding that presented with prolonged history of intermittent pyrexia and tachycardia. Clinical investigations revealed persistently reduced neck mobility, tachydysrhythmia and episodic pyrexia up to 41°C ...
E. Kolovou +11 more
wiley +1 more source
Bridging the bioinformatics gap: tool selection for decentralized AMR genomic surveillance in Africa
Frontiers in Public HealthAntimicrobial resistance (AMR) poses a significant threat to public health, particularly in low- and middle-income countries where centralized genomic surveillance infrastructure is limited.
Niamh Lacy-Roberts +6 more
doaj +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
Hybrid correction of highly noisy Oxford Nanopore long reads using a variable-order de Bruijn graph
, 2017 MotivationThe recent rise of long read sequencing technologies such as Pacific Biosciences and Oxford Nanopore allows to solve assembly problems for larger and more complex genomes than what allowed short reads technologies. However, these long reads are
Pierre Morisse +2 more
core +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley +1 more source
Leishmania infantum JPCM5 sequencing reads generated from total RNA by Oxford Nanopore technology
This project was aimed to sequence total RNA from Leishmania infantum JPCM5 promastigotes using the Oxford Nanopore Technology (ONT) methodology. This dataset consists of two Fastq files, generated by MinION Mk1C (ONT) MC-114562 device (Basecalling was ...
Solana, Jose Carlos +3 more
core +1 more source
Applications of Nanopore sequencing in precision cancer medicine [PDF]
Oxford Nanopore Technologies sequencing, also referred to as Nanopore sequencing, stands at the forefront of a revolution in clinical genetics, offering the potential for rapid, long read, and real‐time DNA and RNA sequencing.
Joosse, Simon A. +10 more
core +1 more source