Results 11 to 20 of about 11,306,965 (261)

Targeted haplotyping in pharmacogenomics using Oxford Nanopore Technologies' adaptive sampling. [PDF]

Front Pharmacol, 2023
Pharmacogenomics (PGx) studies the impact of interindividual genomic variation on drug response, allowing the opportunity to tailor the dosing regimen for each patient. Current targeted PGx testing platforms are mainly based on microarray, polymerase chain reaction, or short-read sequencing.
Deserranno K, Tilleman L, Rubben K, Deforce D, Van Nieuwerburgh F.   +4 more
europepmc   +7 more sources

Simulation of RNA sequencIng with Oxford Nanopore Technologies [PDF]

, 2018
Background Oxford Nanopore Technologies (ONT) platforms produce reads order of magnitudes longer than previous generation of sequencers such as Illumina (several tens to thousands of base pairs). The unprecedented long range information these reads provide is currently used to better solve genomic assembly.
Marchet, Camille, Lima, Leandro
openaire   +2 more sources

Application of Oxford Nanopore Technology to Plant Virus Detection [PDF]

Viruses, 2021
The adoption of Oxford Nanopore Technologies (ONT) sequencing as a tool in plant virology has been relatively slow despite its promise in more recent years to yield large quantities of long nucleotide sequences in real time without the need for prior amplification.
Lia W. Liefting, David W. Waite, Jeremy R. Thompson   +2 more
openaire   +3 more sources

Oxford Nanopore Technology and its Application in Liquid Biopsies

Current Genomics, 2023
Abstract: Advanced medical technologies are transforming the future of healthcare, in particular, the screening and detection of molecular-genetic changes in patients suspected of having a neoplasm. They are based on the assumption that neoplasms release small amounts of various neoplasm- specific molecules, such as tumor DNA, called circulating DNA ...
Levkova, Mariya, Chervenkov, Trifon, Angelova, Lyudmila, Dzenkov, Deyan   +3 more
openaire   +2 more sources

Oxford Nanopore Technologies [ONT] Sequencing: Clinical Validation in Genetically Heterogeneous Disorders. [PDF]

Genes (Basel)
Background/Objectives: Short-read-sequencing (SRS) is currently the standard for genetic testing in inherited human diseases. Intrinsic limitations include PCR dependency, restricted read length, and challenges in identifying structural variants (SVs), copy number variations (CNVs), and intronic small variants (SNVs/indels).
Urtis M, Paganini C, Vilardo V, Tescari A, Minetto S, Cavaliere C, Pilotto A, Giorgianni C, Cattaneo A, Tagliani M, Grasso M, Smirnova A, Ebadi P, Barzon V, Favalli V, Bimbocci A, Baragli M, Magi A, Renieri A, Arbustini E.   +19 more
europepmc   +5 more sources

Optimizing experimental design for genome sequencing and assembly with Oxford Nanopore Technologies [PDF]

Gigabyte, 2020
Abstract Background High quality reference genome sequences are the core of modern genomics. Oxford Nanopore Technologies (ONT) produces inexpensive DNA sequences in excess of 100,000 nucleotides but high error rates make sequence assembly and analysis a non-trivial problem as ...
John M. Sutton, Joshua D. Millwood, A. Case McCormack, Janna L. Fierst   +3 more
openaire   +4 more sources

Oxford Nanopore and Bionano Genomics technologies evaluation for plant structural variation detection [PDF]

BMC Genomics, 2021
Abstract Background Structural Variations (SVs) are very diverse genomic rearrangements. In the past, their detection was restricted to cytological approaches, then to NGS read size and partitionned assemblies.
Canaguier, Aurélie, Guilbaud, Romane, Denis, Erwan, Magdelenat, Ghislaine, Belser, Caroline, Istace, Benjamin, Cruaud, Corinne, Wincker, Patrick, Le Paslier, Marie-Christine, Faivre-Rampant, Patricia, Barbe, Valérie   +10 more
openaire   +5 more sources

Identifying bacterial airways infection in stable severe asthma using Oxford nanopore sequencing technologies [PDF]

, 2022
Previous metagenomic studies in asthma have been limited by inadequate sequencing depth for species-level bacterial identification and by heterogeneity in clinical phenotyping.
Cane, Jennifer, Hinks, timothy, Klenerman, paul, Jabeen, Maisha F, Pavord, ian, Thulborn, samantha, Borg, catherine, Sanderson, Nicholas, Street, teresa L, Foster, Dona, Crook, Derrick, Connolly, clare   +11 more
core   +1 more source

Matched Oxford Nanopore Technologies and Bisulfite Sequencing of the GM24385 Cell Line

, 2022
One of the most widespread genomic modifications is 5-methylcytosine (5mC), which most frequently occurs at CpG dinucleotides. Compared to whole-genome bisulfite sequencing, the traditional method of 5mC detection, nanopore technology can offer many ...
Oxford Nanopore Technologies
core   +1 more source

pycoMeth: a toolbox for differential methylation testing from Nanopore methylation calls

Genome Biology, 2023
We present pycoMeth, a toolbox to store, manage and analyze DNA methylation calls from long-read sequencing data obtained using the Oxford Nanopore Technologies sequencing platform.
Rene Snajder, Adrien Leger, Oliver Stegle, Marc Jan Bonder   +3 more
doaj   +1 more source