Results 1 to 10 of about 8,483 (210)

tert-Butyl Hypochlorite: A Reagent for the Synthesis of Chlorinated Oxindole and Indole Derivatives [PDF]

Molecules
tert-Butyl hypochlorite was employed as a versatile reagent for chlorooxidation of indoles, chlorination of 2-oxindoles, and decarboxylative chlorination of the indole-2-carboxylic acids.
Chun-Yan Liu, Xia Chen, Hai-Long Liu, Nan Wang, Xiao-Yu Zhou   +4 more
doaj   +2 more sources

Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition [PDF]

Beilstein Journal of Organic Chemistry
Oxindoles are an important class of compounds with significant biological activities. Spirocyclic derivatives are present in a variety of natural products.
Beth L. Ritchie, Alexandra Longcake, Iain Coldham   +2 more
doaj   +2 more sources

Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines [PDF]

Nature Communications
The de novo construction of enantioenriched 3-hydroxyindolenines and 3-oxindoles from easily available starting materials has been highly desired. Herein, an enantioselectively intermolecular direct [3 + 2] annulation of aryl amine with 2,3-diketoesters ...
Yong Wang, Yanyan Li, Haohua Chen, Yu Lan, Chao Pi, Yangjie Wu, Xiuling Cui   +6 more
doaj   +2 more sources

Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential [PDF]

Scientific Reports
In this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in four carborane-
Christoph Selg, Vuk Gordić, Tamara Krajnović, Antonio Buzharevski, Markus Laube, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Menyhárt B. Sárosi, Jonas Schädlich, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović-Ivanić, Evamarie Hey-Hawkins   +13 more
doaj   +2 more sources

Regioselective Synthesis of Spiro-Oxindoles via a Ruthenium-Catalyzed Metathesis Reaction

Chemistry Proceedings, 2023
Spiro-oxindoles are important heterocyclic motifs found in various alkaloids, many of which exhibit pharmacological properties. Due to the remarkable biological activity of spiro-oxindoles, significant effort has been made towards the synthesis of ...
Pradip Debnath
doaj   +1 more source

Synthesis of Carbonyl-Containing Oxindoles via Ni-Catalyzed Reductive Aryl-Acylation and Aryl-Esterification of Alkenes

Molecules, 2022
Carbonyl-containing oxindoles are ubiquitous core structures present in many biologically active natural products and pharmaceutical molecules. Nickel-catalyzed reductive aryl-acylation of alkenes using aryl anhydrides or alkanoyl chlorides as acyl ...
Zhengtian Ding, Wangqing Kong
doaj   +1 more source

Synthesis of 2-oxindoles via visible-light photoredox catalysis

Nantong Daxue xuebao. Ziran kexue ban, 2022
To develop an effective synthetic method for the preparation of 2-oxindoles, using readily available N-aryl acrylamides and diethyl bromomalonate as starting materials, and visible light as green and sustainable energy source,the synthesis of various ...
WANG Pengfei; YI Wei; LIU Gongqing
doaj   +1 more source

Highly Efficient Synthesis of 3,3-Disubstituted Oxindoles through Direct Oxidative Alkylarylation of N-Arylacrylamides with Simple Alkanes

SynOpen, 2023
A direct oxidative alkylarylation reaction of N-arylacrylamides with simple alkanes for the synthesis of 3,3-disubstituted oxindoles under metal-free conditions was demonstrated.
Yan Chen, Weihong Song, Zhixiang Zhou, Ziye Zhang, Kai Liu, Xiaofei Zeng, Xiaoyu Han   +6 more
doaj   +1 more source

Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency

Frontiers in Molecular Biosciences, 2021
In this review we compare and discuss results of compounds already reported as anticancer agents based on isatin-derivatives, metalated as well as non-metallated.
Raphael Enoque Ferraz de Paiva, Eduardo Guimarães Vieira, Daniel Rodrigues da Silva, Camila Anchau Wegermann, Ana Maria Costa Ferreira   +4 more
doaj   +1 more source

A nickel phosphide nanoalloy catalyst for the C-3 alkylation of oxindoles with alcohols

Scientific Reports, 2021
Although transition metal phosphides are well studied as electrocatalysts and hydrotreating catalysts, the application of metal phosphides in organic synthesis is rare, and cooperative catalysis between metal phosphides and supports remains unexplored ...
Shu Fujita, Kohei Imagawa, Sho Yamaguchi, Jun Yamasaki, Seiji Yamazoe, Tomoo Mizugaki, Takato Mitsudome   +6 more
doaj   +1 more source