Results 61 to 70 of about 10,743 (200)
The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis
Allergy, EarlyView.ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith +9 more
wiley +1 more source
Overview of all determined individual oxylipins.
, 2018 Overview of all determined individual oxylipins.
P. M. J. Welsing (2583325) +8 more
core +1 more source
DataSheet1_Concentration of milk oxylipins after heat and homogenization treatments.pdf
, 2023 Heat treatment and homogenization of milk are common processing steps intended to reduce microbial load for safe human consumption, and to avoid creaming, respectively.
Gulustan Ozturk (5966996) +7 more
core +1 more source
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
Development of a desorption electrospray ionization –multiple-reaction-monitoring mass spectrometry (DESI-MRM) workflow for spatially mapping oxylipins in pulmonary tissue [PDF]
Oxylipins are a class of low abundant lipids formed via oxygenation of fatty acids. These compounds include potent signaling molecules (e.g., octadecanoids, eicosanoids) that can exert essential functions in the pathophysiology of inflammatory diseases ...
Mikael, Adner +4 more
core +2 more sources
Functional Significance and Implications of Phyto-Oxylipins as Potential Anti-Cancer Agents
Natural Product CommunicationsObjective Phyto-oxylipins are lipid molecules produced in plants by the oxidative transformation of unsaturated fatty acids via diverse metabolic pathways.
Aboagye Kwarteng Dofuor
doaj +1 more source
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source
Western diet effects on hepatic ω6-PUFA derived oxylipins.
, 2019 ω6-PUFA derived oxylipins were quantified using a targeted LC/MS approach (Materials and methods). A: ω6 PUFA-derived oxylipins in RD-fed mice. B: Diet effects on ω6 PUFA-derived oxylipins. Results are presented as fold change in oxylipins induced by the
Melinda H. Spooner (6551933) +5 more
core +1 more source
Immunology, EarlyView.Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar +8 more
wiley +1 more source
Western diet effects on hepatic ω3-PUFA derived oxylipins.
, 2019 ω3 PUFA derived oxylipins were quantified using a un-targeted LC/MS approach (Materials and methods)s. A: ω3 PUFA-derived oxylipins in RD-fed mice. B: Diet effects on ω3 PUFA-derived oxylipins. Results are presented as fold change in oxylipins induced by
Melinda H. Spooner (6551933) +5 more
core +1 more source