Results 151 to 160 of about 12,246 (181)
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Novel Series of Dihydropyridinone P2X7 Receptor Antagonists
Journal of Medicinal Chemistry, 2015Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During development, a number of issues were successfully addressed, such as metabolic stability, plasma stability, GSH adduct formation, and aniline mutagenicity.
Francisco, Lopez-Tapia +23 more
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P2X7 receptors mediate ischemic damage to oligodendrocytes
Glia, 2009AbstractBrain ischemia leading to stroke is a major cause of disability in developed countries. Therapeutic strategies have most commonly focused on protecting neurons from ischemic damage. However, ischemic damage to white matter causes oligodendrocyte death, myelin disruption, and axon dysfunction, and it is partially mediated by glutamate ...
Maria, Domercq +5 more
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Human rheumatoid synoviocytes express functional P2X7 receptors
Journal of Molecular Medicine, 2008Human type B synoviocytes are involved in joint injury during rheumatic diseases by producing inflammatory mediators such as interleukin-6 (IL-6). The increased level of purine and pirimidine nucleotides in the synovial fluid of rheumatoid arthritis (RA) patients could activate the large family of P2 receptors.
Caporali, F. +9 more
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1,4-Naphthoquinones potently inhibiting P2X7 receptor activity
European Journal of Medicinal Chemistry, 2018P2X7 receptor (P2X7R) is an ATP-gated ion-channel with potential therapeutic applications. In this study, we prepared and searched a series of 1,4-naphthoquinones derivatives to evaluate their antagonistic effect on both human and murine P2X7 receptors.
R.X. Faria +10 more
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Regulation of Immune Response by P2X7 Receptor
Critical Reviews™ in Immunology, 2006The P2X7 receptor is an ATP-gated cation channel that is widely expressed in cells of the immune system. Signal transduction is accompanied by fast influx of Ca2+ and Na+, and efflux of K+. This receptor differs from other members of the P2X family in its relatively low affinity for ATP, the presence of a long C-terminal region that contains several ...
Lanfen, Chen, Celia F, Brosnan
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[Detection of P2z/P2x7 receptors].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2005To detect the P2z/P2x7 receptors of human leukocytes.Re-suspending different kinds of leukemic cells, including CEM, THP-1, HL-60, NB4, Dami/Damin and Raji cells in buffer; adjusting their concentration to 2 x 10(7)/ml, and then detecting the P2z/P2x7 receptors respectively.(1) It was found that 0.4 mmol/L ATP enhanced obviously the fluorenscence ...
Liming, Peng, Hanshuo, Yang, Qin, Zhang
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
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