Results 11 to 20 of about 41,761 (267)

PAMAM dendrimer - cell membrane interactions

Advances in Colloid and Interface Science, 2018
PAMAM dendrimers have been conjectured for a wide range of biomedical applications due to their tuneable physicochemical properties. However, their application has been hindered by uncertainties in their cytotoxicity, which is influenced by dendrimer generation (i.e.
Fox, Laura J, Richardson, Robert M, Briscoe, Wuge H   +2 more
semanticscholar   +7 more sources

PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review. [PDF]

Int J Nanomedicine, 2020
Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to current treatment options. Despite major advancements in the fields of surgery and chemoradiotherapy over the last few decades, the life expectancy for someone ...
Fana M, Gallien J, Srinageshwar B, Dunbar GL, Rossignol J.   +4 more
europepmc   +2 more sources

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. [PDF]

Molecules, 2020
Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested ...
Svenningsen SW, Frederiksen RF, Counil C, Ficker M, Leisner JJ, Christensen JB.   +5 more
europepmc   +2 more sources

Detection of dengue using PAMAM dendrimer integrated tapered optical fiber sensor. [PDF]

Sci Rep, 2019
The exponential escalation of dengue cases has indeed become a global health crisis. This work elaborates on the development of a biofunctionalized tapered optical fiber (TOF) based sensor with the integration of polyamidoamine (PAMAM) dendrimer for the ...
Mustapha Kamil Y, Al-Rekabi SH, Yaacob MH, Syahir A, Chee HY, Mahdi MA, Abu Bakar MH.   +6 more
europepmc   +2 more sources

Conjugate of PAMAM Dendrimer, Doxorubicin and Monoclonal Antibody-Trastuzumab: The New Approach of a Well-Known Strategy. [PDF]

Polymers (Basel), 2018
The strategy utilizing trastuzumab, a humanized monoclonal antibody against human epidermal growth receptor 2 (HER-2), as a therapeutic agent in HER-2 positive breast cancer therapy seems to have advantage over traditional chemotherapy, especially when ...
Marcinkowska M, Sobierajska E, Stanczyk M, Janaszewska A, Chworos A, Klajnert-Maculewicz B.   +5 more
europepmc   +2 more sources

New Dendrimers: Synthesis and Characterization of POPAM−PAMAM Hybrid Dendrimers [PDF]

Macromolecules, 2008
Recently developed multifunctional cancer therapeutic nano-device production is based on poly(amidoamine) PAMAM generation 5 (G5) dendrimer as a carrier 1-5. Scale up synthesis of this nano-device is limited because of long reaction sequence (12 reaction steps) and long and not easy work up of the products after each reaction step.
István J, Majoros, Christopher R, Williams, Donald A, Tomalia, James R, Baker   +3 more
openaire   +2 more sources

In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates. [PDF]

Molecules, 2017
The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug.
Najlah M, Freeman S, Khoder M, Attwood D, D'Emanuele A.   +4 more
europepmc   +2 more sources

Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer [PDF]

, 2008
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Biomacromolecules, copyright © American Chemical Society after peer review.
Angele P., Babensee J. E., Badylak S., Badylak S. F., Badylak S. F., Badylak S. F., Billiar K., Brody S., Burugapalli K., Buttafoco L., Chandrasekar D., Charulatha V., Chen R. R., Coburn J. C., Curotto E., Domanski D. M., Duan X., Duan X., Duan X., DuBay D. A., Dumas P., Ferrando J. M., Garcia Y., Grinnell F., Henry J. A., Hodde J., Hodde J. P., Ko R., Kochupura P. V., Koizumi N. J., Lee J. M., Lee S. H., Liang H. C., Ma L., Ma Z., Malafaya P. B., McDevitt C. A., McKegney M., Meinert M., Najlah M., Nourse A., Olde Damink L. H., Olde Damink L. H., Osborne C. S., Papagiannaros A., Pek Y. S., Pieper J. S., Saito H., Sokolsky-Papkov M., Tabata Y., Tessmar J. K., Unsworth J. M., van Wachem P. B., van Wachem P. B., van Wachem P. B., Voytik-Harbin S. L., Wissink M. J., Wissink M. J., Wolkers W. F., Yee N., Zhong S., Zilla P.   +61 more
core   +1 more source

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

Molecules, 2018
Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties.
Daniel M. Shadrack, Hulda S. Swai, Joan J. E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro   +4 more
doaj   +1 more source

Dendrimers in gene delivery [PDF]

, 2005
Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also ...
Dufès, Christine, Schätzlein, Andreas G., Uchegbu, Ijeoma F.   +2 more
core   +1 more source