Results 11 to 20 of about 5,727 (183)
Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier [PDF]
African Journal of Gastroenterology and Hepatology, 2019 Aims: This study used an animal xenograft model of gastric cancer induction to investigate the therapeutic effects of capecitabine polyamidoamine (PAMAM) dendrimer complex against cancer and its potential side effects.
Sharareh Jafari +5 more
doaj +1 more source
Molecules, 2018 Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties.
Daniel M. Shadrack +4 more
doaj +1 more source
Development of Tat-Conjugated Dendrimer for Transdermal DNA Vaccine Delivery
Journal of Pharmacy & Pharmaceutical Sciences, 2016 PURPOSE: In order to enhance cellular uptake and to facilitate transdermal delivery of DNA vaccine, polyamidoamine (PAMAM) dendrimers conjugated with HIV transactivator of transcription (TAT) was developed.
Azadeh Bahadoran +4 more
doaj +1 more source
Comparative Evaluation of Lipofectamine and Dendrimer for Transfection of Short RNA Into Human T47D and MCF-10A Cell Lines [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: Non-viral transfection approaches are extensively used in cancer therapy. The future of cancer therapy lies on targeted and efficient drug/gene delivery.
Zohreh Jahanafrooz +2 more
doaj +1 more source
Acetylation of PAMAM dendrimers for cellular delivery of siRNA [PDF]
BMC Biotechnology, 2009 AbstractBackgroundThe advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process.
Waite, Carolyn L +3 more
openaire +5 more sources
High Fluorescent Porphyrin-PAMAM-Fluorene Dendrimers [PDF]
Molecules, 2015 Two new classes of dendrimers bearing 8 and 32 fluorene donor groups have been synthesized. The first and second generations of these porphyrin-PAMAM-fluorene dendrimers were characterized by 1H-NMR, 13C-NMR, FTIR, UV-vis spectroscopy, elemental analyses and MALDI-TOF mass spectrometry.
Garfias-Gonzalez, Karla +6 more
openaire +3 more sources
Label-Free Detection of Saxitoxin with Field-Effect Device-Based Biosensor
Nanomaterials, 2022 Saxitoxin (STX) is a highly toxic and widely distributed paralytic shellfish toxin (PSP), posing a serious hazard to the environment and human health. Thus, it is highly required to develop new STX detection approaches that are convenient, desirable, and
Najeeb Ullah +5 more
doaj +1 more source
Intrinsic Fluorescence of PAMAM Dendrimers—Quenching Studies [PDF]
Polymers, 2018 Intrinsic, non-traditional fluorescence of polyamidoamine (PAMAM) dendrimers that do not possess classical fluorophores has been attracting considerable interest for the last decade. Many hypotheses regarding the source of the fluorescence have appeared, but some of them are still disputable.
Malgorzata Konopka +2 more
openaire +2 more sources
Curcumin encapsulation using dendrimer PAMAM G4 conjugated with polyethylene glycol to improve the properties of gel dossage form [PDF]
Pharmaciana, 2018 Curcumin had a low bioavailability, to improve it than curcumin was encapsulated in the PAMAM dendrimer conjugated PEG. To facilitate topical use, curcumin dendrimer was combined with a carbomer 940 that can produce hydration conditions in the stratum ...
Rahmah Elfiyani +2 more
doaj +1 more source
PAMAM dendrimer - cell membrane interactions
Advances in Colloid and Interface Science, 2018 PAMAM dendrimers have been conjectured for a wide range of biomedical applications due to their tuneable physicochemical properties. However, their application has been hindered by uncertainties in their cytotoxicity, which is influenced by dendrimer generation (i.e.
Fox, Laura J +2 more
openaire +4 more sources