Results 61 to 70 of about 5,727 (183)

Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
wiley   +1 more source

PAMAM dendrimers based co-delivery of methotrexate and berberine for targeting of Hela cancer cells

Toxicology Reports
Polyamidoamine dendrimer (PAMAM) is a class of synthetic macromolecular polymers for targeted drug delivery. PAMAM dendrimers are characterized by a pure defined structure, adjustable nanoscale dimensions, mono-dispersity, and versatile surface ...
Hossein Majidzadeh, Mostafa Araj-Khodaei, Ayuob Aghanejad, Maryam Ghaffari, Amir Jafari, Forough Jenanifard, Jafar Ezzati Nazhad Dolatabadi, Hashem Andishmand, Michael R. Hamblin   +8 more
doaj   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Effect of methotrexate conjugated PAMAM dendrimers on the viability of MES-SA uterine cancer cells

Journal of Pharmacy and Bioallied Sciences, 2014
The aim of this work was to synthesize methotrexate (MTX)-polyamidoamine (PAMAM) dendritic nanoconjugates and to study their effect on cell viability in uterine sarcoma cells.
Samreen Khatri, Nandita G Das, Sudip K Das   +2 more
doaj   +1 more source

Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang, Jing Fei, Rangrang Fan, Haifeng Chen, Liangxue Zhou, Gang Guo   +5 more
wiley   +1 more source

Dendrimers bind antioxidant polyphenols and cisplatin drug.

PLoS ONE, 2012
Synthetic polymers of a specific shape and size play major role in drug delivery systems. Dendrimers are unique synthetic macromolecules of nanometer dimensions with a highly branched structure and globular shape with potential applications in gene and ...
Amine Abderrezak, Philippe Bourassa, Jean-Sebastian Mandeville, Reza Sedaghat-Herati, Heidar-Ali Tajmir-Riahi   +4 more
doaj   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, Volume 36, Issue 63, 6 August 2026.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

Induction of a robust immune response against avian influenza virus following transdermal inoculation with H5-DNA vaccine formulated in modified dendrimer-based delivery system in mouse model

International Journal of Nanomedicine, 2017
Azadeh Bahadoran,1,2 Mehdi Ebrahimi,3 Swee Keong Yeap,1 Nikoo Safi,1 Hassan Moeini,4 Mohd Hair-Bejo,1,5 Mohd Zobir Hussein,6 Abdul Rahman Omar1,5 1Institute of Bioscience, Universiti Putra Malaysia, UPM, Serdang, 2Department of Microbiology, Faculty of ...
Bahadoran A, Ebrahimi M, Yeap SK, Safi N, Moeini H, Hair-Bejo M, Hussein MZ, Omar AR   +7 more
doaj  

Molecular dynamics study of pH-responsive PAMAM dendrimer–topotecan complex: loading mechanism, membrane transport, and release mechanism

Results in Surfaces and Interfaces
The clinical efficacy of topotecan (TPT) is limited by its instability and rapid clearance, motivating the search for nanoscale carriers capable of enhancing its delivery.
Mehdi Yoosefian, Elham Rahmanifar, Vahid Saheb, Kasim Sakran Abass   +3 more
doaj   +1 more source

Dendrimeric Antigens for Passive Mast Cell Activation in the Evaluation of Amoxicillin Allergy

Allergy, Volume 81, Issue 8, Page 2898-2909, August 2026.
DeAns with defined nanoscale structure reveal that conjugate size and determinant density govern IgE‐mediated effector‐cell activation in AX allergy. All DeAn generations bind to sIgE in inhibition immunoassay, but only larger DeAns trigger FcεRI‐dependent responses in mouse MC, huRBL‐2H3, and LUVA cells.
Amene Tesfaye Ayane, Maria Salas, Sara Benede, Maria J. Rodriguez‐Sanchez, Maria J. Rodriguez‐Sojo, Isabel M. Jiménez‐Sánchez, Gador Bogas, Ezequiel Perez‐Inestrosa, Cristobalina Mayorga, Juan L. Paris, Alba Rodríguez‐Nogales, María J. Torres, María I. Montañez   +12 more
wiley   +1 more source