Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers. [PDF]
J Gen PhysiolGupta et al. show that Pannexin 1 (PANX1) channels can function as both hexamers and heptamers, but that heptameric PANX1 shows higher conductance, longer mean open times, and supports greater ATP release and dye uptake.
Gupta S +5 more
europepmc +2 more sources
International Journal of Oral Science, 2023 Severe muscle injury is hard to heal and always results in a poor prognosis. Recent studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine, however, whether extracellular vesicles have therapeutic effects
Qingyuan Ye +13 more
doaj +2 more sources
Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing reactive oxygen species, endoplasmic reticulum stress, and Pannexin-1-mediated ferroptosis. [PDF]
Biomol Biomed, 2023 Diabetic cardiomyopathy (DCM) is a serious complication and death cause of diabetes mellitus (DM). Recent cardiology studies suggest that spermidine (SPD) has cardioprotective effects.
Sun J +9 more
europepmc +2 more sources
Emerging functions of Pannexin 1 in the eye [PDF]
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
doaj +3 more sources
N-methyl-D-aspartate receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats. [PDF]
PainThe N-methyl-D-aspartate (NMDA) receptor activation in dorsal horn neurons triggers an NMDAR-Src-pannexin 1 (Panx1) signaling pathway, where Panx1 acts as an enhancing effector in neuropathic pain.
Zepeda-Morales K +8 more
europepmc +2 more sources
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death. [PDF]
J Lipid ResSterol-regulatory element binding proteins (SREBPs) are a conserved transcription factor family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is transported from the endoplasmic reticulum to the Golgi apparatus where it ...
Xiong Y +5 more
europepmc +2 more sources
Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice. [PDF]
Front Cell Dev BiolChronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in maintaining glomerular function, yet their involvement in CKD pathogenesis ...
Lucero CM +5 more
europepmc +2 more sources
Global pannexin 1 deletion increases tumor‐infiltrating lymphocytes in the BRAF/Pten mouse melanoma model [PDF]
Molecular OncologyImmunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+ T cells, but have a limited patient response rate, in part due to limited tumoral immune cell infiltration.
Rafael E. Sanchez‐Pupo +8 more
doaj +2 more sources
Pannexin-1 Channels as Mediators of Neuroinflammation [PDF]
International Journal of Molecular Sciences, 2021 Neuroinflammation is a major component of central nervous system (CNS) injuries and neurological diseases, including Alzheimer’s disease, multiple sclerosis, neuropathic pain, and brain trauma. The activation of innate immune cells at the damage site causes the release of pro-inflammatory cytokines and chemokines, which alter the functionality of ...
Seo, Joon Ho +2 more
openaire +4 more sources
Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy [PDF]
International Journal of Ophthalmology, 2022 AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy. METHODS: The study included three age and gender-matched groups of 20 cataract patients with no diabetes or additional disease ...
Fatih Cem Gül +4 more
doaj +1 more source