Results 41 to 50 of about 27,134,532 (169)

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation [PDF]

Journal of Cell Science, 2010
Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In
Steven J, Celetti, Kyle N, Cowan, Silvia, Penuela, Qing, Shao, Jared, Churko, Dale W, Laird   +5 more
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Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Frontiers in Neurology, 2022
AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng, Wenwen Tang, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao   +6 more
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Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]

PLoS ONE, 2014
P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya, Phuong Dao-Ung, Iman Jalilian, Mari Spildrejorde, Kristen K Skarratt, Stephen J Fuller, Ronald Sluyter, Leanne Stokes   +7 more
doaj   +1 more source

Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease

Physiological Reports, 2023
Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov   +5 more
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Pannexin 1 and Pannexin 3 Channels Regulate Skeletal Muscle Myoblast Proliferation and Differentiation [PDF]

Journal of Biological Chemistry, 2014
Pannexins constitute a family of three glycoproteins (Panx1, -2, and -3) forming single membrane channels. Recent work demonstrated that Panx1 is expressed in skeletal muscle and involved in the potentiation of contraction. However, Panxs functions in skeletal muscle cell differentiation, and proliferation had yet to be assessed.
Langlois, Stéphanie, Xiang, Xiao, Young, Kelsey, Cowan, Bryce J., Penuela, Silvia, Cowan, Kyle N.   +5 more
openaire   +2 more sources

Knockout of Pannexin-1 Induces Hearing Loss [PDF]

International Journal of Molecular Sciences, 2018
Mutations of gap junction connexin genes induce a high incidence of nonsyndromic hearing loss. Pannexin genes also encode gap junctional proteins in vertebrates. Recent studies demonstrated that Pannexin-1 (Panx1) deficiency in mice and mutation in humans are also associated with hearing loss.
Chen, Jin, Liang, Chun, Zong, Liang, Zhu, Yan, Zhao, Hong-Bo   +4 more
openaire   +2 more sources

S-Nitrosylation Inhibits Pannexin 1 Channel Function [PDF]

Journal of Biological Chemistry, 2012
S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity.
Alexander W, Lohman, Janelle L, Weaver, Marie, Billaud, Joanna K, Sandilos, Rachael, Griffiths, Adam C, Straub, Silvia, Penuela, Norbert, Leitinger, Dale W, Laird, Douglas A, Bayliss, Brant E, Isakson   +10 more
openaire   +2 more sources

P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]

PLoS ONE, 2013
We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung, Chul Hee Choi, Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen Sellami, Özlem Yilmaz, David M Ojcius   +7 more
doaj   +1 more source

Pannexin 1 deficiency can induce hearing loss [PDF]

Biochemical and Biophysical Research Communications, 2015
Gap junctions play a critical role in hearing. Connexin gap junction gene mutations can induce a high incidence of hearing loss. Pannexin (Panx) gene also encodes gap junction proteins in vertebrates. Panx1 is a predominant pannexin isoform and has extensive expression in the cochlea.
Hong-Bo, Zhao, Yan, Zhu, Chun, Liang, Jin, Chen   +3 more
openaire   +2 more sources

Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation

Neural Development, 2012
Background Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain. After discovering pannexin 1 expression in postnatal neural stem and progenitor cells we sought to elucidate its functional role in ...
Wicki-Stordeur Leigh E, Dzugalo Adrian D, Swansburg Rose M, Suits Jocelyne M, Swayne Leigh   +4 more
doaj   +1 more source