Results 51 to 60 of about 27,134,532 (169)
Identification of Pannexins in Rat Nasal Mucosa
Allergy & Rhinology, 2013 Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D. +7 more
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Perspectives on the role of Pannexin 1 in neural precursor cell biology
Neural Regeneration Research, 2016 We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous
Juan C Sanchez-Arias +2 more
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Structural order in Pannexin 1 cytoplasmic domains [PDF]
Channels, 2014 Pannexin 1 forms ion and metabolite permeable hexameric channels with abundant expression in the central nervous system and elsewhere. Although pannexin 1 does not form intercellular channels, a common channel topology and oligomerization state, as well as involvement of the intracellular carboxyl terminal (CT) domain in channel gating, is shared with ...
Gaelle, Spagnol +2 more
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Biomedicines, 2023 Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to interact with membrane proteins such as TRPV2 channels, organic ...
Claudia García-Rodríguez +7 more
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Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization [PDF]
Cell Communication & Adhesion, 2013 Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking. Panx2, another family member, has a longer and highly dissimilar C-terminus.
Leigh E, Wicki-Stordeur +2 more
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Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
eLife, 2020 ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured human ...
Hiromi Imamura +8 more
doaj +1 more source
Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance
Life, 2021 Mucociliary clearance (MCC) is a dominant component of pulmonary host defense. In health, the periciliary layer (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force.
Catharina van Heusden +3 more
doaj +1 more source
Pannexin-1 Deficiency Decreases Epileptic Activity in Mice [PDF]
International Journal of Molecular Sciences, 2020 Objective: Pannexin-1 (Panx1) is suspected of having a critical role in modulating neuronal excitability and acute neurological insults. Herein, we assess the changes in behavioral and electrophysiological markers of excitability associated with Panx1 via three distinct models of epilepsy.
Mark S. Aquilino +6 more
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Biomedicines, 2022 Pannexins are transmembrane glycoproteins that constitute channels involved in purinergic signaling through ATP release from cells in various physiological and pathological processes.
Ivo Jeličić +6 more
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Pannexin 1 activation and inhibition is permeant‐selective [PDF]
The Journal of Physiology, 2020 Key points The large‐pore channel pannexin 1 (Panx1) is expressed in many cell types and can open upon different, yet not fully established, stimuli. Panx1 permeability is often inferred from channel permeability to fluorescent dyes, but it is currently unknown whether dye permeability translates to permeability to other molecules. Cell shrinkage and C‐
Brian Skriver Nielsen +6 more
openaire +3 more sources