Results 61 to 70 of about 27,134,532 (169)
Taking a close look at a large-pore channel
eLife, 2020 The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
Pablo S Gaete, Jorge E Contreras
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Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves
Frontiers in Cellular Neuroscience, 2017 The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton +10 more
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Extracellular ATP hydrolysis inhibits synaptic transmission by increasing ph buffering in the synaptic cleft. [PDF]
PLoS Biology, 2014 Neuronal computations strongly depend on inhibitory interactions. One such example occurs at the first retinal synapse, where horizontal cells inhibit photoreceptors.
Rozan Vroman +6 more
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Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism [PDF]
Journal of Biological Chemistry, 2014 Anti-tumor immune responses have been linked to the regulated release of ATP from apoptotic cancer cells to engage P2 purinergic receptor signaling cascades in nearby leukocytes. We used the Jurkat T cell acute lymphocytic leukemia model to characterize the role of pannexin-1 (Panx1) channels in the release of nucleotides during chemotherapeutic drug ...
Andrea, Boyd-Tressler +3 more
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Frontiers in Molecular Neuroscience, 2017 Background: Accumulating evidence suggests that neuroinflammation plays a critical role in early brain injury after subarachnoid hemorrhage (SAH). Pannexin-1 channels, as a member of gap junction proteins located on the plasma membrane, releases ATP ...
Ling-Yun Wu +13 more
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Pannexin 1 and Adipose Tissue [PDF]
, 2017 Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the pathway for controlled ATP release from adipocytes is unknown. Here, we investigated whether Pannexin 1 (Panx1)
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Cells, 2022 Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to neuronal pathologies such as epilepsy and Alzheimer’s disease (AD). The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic plasticity,
Carolina Flores-Muñoz +11 more
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Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels” [PDF]
The Journal of Neuroscience, 2009 Purinergic signaling plays distinct and important roles in the CNS, including the transmission of calcium signals between astrocytes. Gap junction hemichannels are among the mechanisms proposed by which astrocytes might release ATP; however, whether the gap junction protein connexin43 (Cx43) forms these “hemichannels” remains controversial. Recently, a
Rodolfo, Iglesias +4 more
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Cancer Science, EarlyView.Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda +2 more
wiley +1 more source
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma
The FEBS JournalIn this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes‐associated protein (YAP).
Samar Sayedyahossein +13 more
semanticscholar +1 more source