Results 71 to 80 of about 1,521 (154)

Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives

The Journal of Physiology, Volume 604, Issue 4, Page 1592-1606, 15 February 2026.
Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu, Laura Beth Payne, Robert G. Gourdie   +2 more
wiley   +1 more source

Acute activation of hemichannels by ethanol leads to Ca2+-dependent gliotransmitter release in astrocytes

Frontiers in Cell and Developmental Biology
Multiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez, Claudia García-Rodríguez, Jesús E. Marillán, Sergio A. Vergara, Tanhia F. Alvear, Arantza Farias-Pasten, Juan C. Sáez, Mauricio A. Retamal, Maximiliano Rovegno, Fernando C. Ortiz, Juan A. Orellana   +10 more
doaj   +1 more source

Connexins and pannexins: New insights into microglial functions and dysfunctions

Frontiers in Molecular Neuroscience, 2016
In a physiological context, microglia adopt a resting phenotype that is associated with the production of anti-inflammatory and neurotrophic factors. In response to a wide variety of insults, they shift to the activated phenotype that is necessary for ...
Rosario Gajardo-Gómez, Valeria C Labra, Juan Andrés Orellana   +2 more
doaj   +1 more source

Connexins and pannexins in liver damage

EXCLI journal, 2016
EXCLI Journal;Vol.
Crespo Yanguas, Sara, Willebrords, Joost, Maes, Michaël, da Silva, Tereza Cristina, Veloso Alves Pereira, Isabel, Cogliati, Bruno, Zaidan Dagli, Maria Lucia, Vinken, Mathieu   +7 more
openaire   +4 more sources

The cellular life of pannexins [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractThe mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2, and Panx3 has received considerable attention in the last 10 years given their newly discovered physiological roles in development and disease. Pannexins exhibit diverse subcellular profiles indicating that they may serve distinct roles in cells and tissues of
Silvia Penuela, Dale W. Laird
openaire   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

S-Nitrosylation Inhibits Pannexin 1 Channel Function [PDF]

Journal of Biological Chemistry, 2012
S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity.
Alexander W, Lohman, Janelle L, Weaver, Marie, Billaud, Joanna K, Sandilos, Rachael, Griffiths, Adam C, Straub, Silvia, Penuela, Norbert, Leitinger, Dale W, Laird, Douglas A, Bayliss, Brant E, Isakson   +10 more
openaire   +2 more sources

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

A quantized mechanism for activation of pannexin channels

Nature Communications, 2017
Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conductance
Yu-Hsin Chiu, Xueyao Jin, Christopher B. Medina, Susan A. Leonhardt, Volker Kiessling, Brad C. Bennett, Shaofang Shu, Lukas K. Tamm, Mark Yeager, Kodi S. Ravichandran, Douglas A. Bayliss   +10 more
doaj   +1 more source

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

Frontiers in Cellular Neuroscience, 2019
Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper ...
Sebastián Vejar, Juan E. Oyarzún, Juan E. Oyarzún, Mauricio A. Retamal, Mauricio A. Retamal, Fernando C. Ortiz, Juan A. Orellana, Juan A. Orellana   +7 more
doaj   +1 more source