Results 81 to 90 of about 1,521 (154)
Aquaculture Research, Volume 2026, Issue 1, 2026.The spotted sea bass (Lateolabrax maculatus) is a key aquaculture species in China. However, issues, such as farmed fish escape, closed‐cycle farming, and nonstandardized breeding, have intensified inbreeding depression and germplasm degradation, necessitating an evaluation of escapement‐induced genetic introgression and diversity loss in wild ...
Huilong Chen +5 more
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Connexins and pannexins: from biology towards clinical targets
Swiss Medical Weekly, 2016 Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the ...
Paolo Meda, Jacques-Antoine Haefliger
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The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease
Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira +2 more
wiley +1 more source
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Metabolic reorganization and chronic inflammation are dynamic and diverse events in the tumor microenvironment (TME) that cause tumor propagation, spreading, and resistance to treatment. However, copper‐induced cell death (cuproptosis), which is a newly discovered form of regulated cell death (RCD) induced by high intracellular copper ions and is a ...
Yan Wang +6 more
wiley +1 more source
Pannexin Channel Inhibition [PDF]
Circulation Research, 2018 More than 50 years after spironolactone has come on the market its mechanism of action continues to expand. In this issue of Circulation Research , Good et al1 document the discovery that spironolactone is not only an inhibitor of the mineralocorticoid receptor but also inhibits pannexin 1 channels.
openaire +2 more sources
Mechanism of GSDMD in the Pathogenesis of Pasteurella multocida PmCQ2
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Pasteurella multocida serotype A (PmCQ2), a Gram‐negative zoonotic pathogen, causes severe respiratory disease in a variety of domestic and wild animals, leading to high morbidity and mortality and substantial agricultural economic losses. Pyroptosis, a gasdermin‐mediated programmed cell death mechanism, facilitates pathogen clearance but exacerbates ...
Qingqing Yang +8 more
wiley +1 more source
Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases
Frontiers in Physiology, 2014 In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez +3 more
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Advanced Science, Volume 12, Issue 45, December 4, 2025.Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang +17 more
wiley +1 more source
Roles of gap junctions, connexins and pannexins in epilepsy
Frontiers in Physiology, 2014 Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are ...
Shanthini eMylvaganam +3 more
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The biochemistry and function of pannexin channels
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Three family members compose the pannexin family of channel-forming glycoproteins (Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single-membrane channels that are regulated by post-translational modifications, channel intermixing, and sub-cellular expression profiles.
Penuela, Silvia +2 more
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