The 100 facets of the Passerini reaction. [PDF]
Chem Sci, 2021 This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini three component reaction.
Banfi L +4 more
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Synthesis of Polyoxygenated Heterocycles by Diastereoselective Functionalization of a Bio-Based Chiral Aldehyde Exploiting the Passerini Reaction [PDF]
Molecules, 2020 A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an erythritol derivative, was further functionalized and then submitted to stereoselective Passerini reactions, allowing the synthesis of a small library of new ...
Gabriella Vitali Forconesi +5 more
doaj +2 more sources
Stereochemical control of the Passerini reaction. [PDF]
Org Lett, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Andreana PR, Liu CC, Schreiber SL.
europepmc +5 more sources
Strain and Complexity, Passerini and Ugi Reactions of Four‐Membered Heterocycles and Further Elaboration of TOSMIC Product [PDF]
ChemistryOpen, 2023 Straightforward and general Passerini and Ugi procedures have been developed to incorporate four‐membered heterocycles into highly functionalized scaffolds.
Gábor Sztanó +2 more
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Creating unimolecular multivalent diversity in protein conjugates via the Passerini multicomponent bioconjugation with isocyanoproteins [PDF]
Communications ChemistryThe ability to conjugate multiple molecules to a protein is of great interest for pharmaceutical and vaccine development, especially if this can be achieved in a one-pot procedure.
Ana R. Humpierre +11 more
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Accessing Promising Passerini Adducts in Anticancer Drug Design [PDF]
MoleculesThe 3-component Passerini reaction (3CPR), discovered little more than 100 years ago, has been demonstrated in the last few decades to be a valuable tool for accessing structural diversity and complexity, essential topics to consider in drug discovery ...
Ana Margarida Janeiro +3 more
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Innovative synthesis of drug-like molecules using tetrazole as core building blocks [PDF]
Beilstein Journal of Organic ChemistryTetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules.
Jingyao Li +3 more
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Total Synthesis of 4-epi-Bengamide E [PDF]
MoleculesBengamide E is a bioactive natural product that was isolated from Jaspidae sponges by Crews and co-workers in 1989. It displays a wide range of biological activities, including antitumor, antibiotic, and anthelmintic properties.
Gabriella Vitali Forconesi +8 more
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Green and three-component synthesis of 2-cyclohexylamino-2-oxo-1-arylethyl/alkyl thiophene-3-carboxylates in aqueous medium [PDF]
شیمی کاربردی روز, 2021 From the Passerini three-component reaction between cyclohexyl isocyanide, thiophene-2-carboxylic acid and aryl/alkyl aldehydes, some new compounds of 2-cyclohexylamino-2-oxo-1-arylethyl/alkyl thiophene-3-carboxylates have been synthesized in 30-45 min ...
sima mosavi niaraki +3 more
doaj +1 more source
SynOpen, 2021 An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid +3 more
doaj +1 more source