Results 71 to 80 of about 391,643 (293)

Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy [PDF]

Cancer Gene Therapy, 2008
The delivery of stimulatory signals to dendritic cells (DCs) in the tumor microenvironment could be an effective means to break tumor-induced tolerance. The work presented here evaluates the immunostimulatory properties of pathogen-associated molecular patterns (PAMPs), microbial molecules which bind Toll-like receptors and deliver activating signals ...
C, Tosch, M, Geist, C, Ledoux, C, Ziller-Remi, S, Paul, P, Erbs, N, Corvaia, P, Von Hoegen, J-M, Balloul, H, Haegel   +9 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PAMPs of Piscirickettsia salmonis Trigger the Transcription of Genes Involved in Nutritional Immunity in a Salmon Macrophage-Like Cell Line

Frontiers in Immunology, 2022
The innate immune system can limit the growth of invading pathogens by depleting micronutrients at a cellular and tissue level. However, it is not known whether nutrient depletion mechanisms discriminate between living pathogens (which require nutrients)
Danixa Pamela Martínez, Danixa Pamela Martínez, Cristian Oliver, Natacha Santibañez, José Leonardo Coronado, Ricardo Oyarzún-Salazar, Ricardo Enriquez, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Luis Vargas-Chacoff, Alex Romero, Alex Romero   +11 more
doaj   +1 more source

The Biosemiotic Approach in Biology : Theoretical Bases and Applied Models [PDF]

, 2011
Biosemiotics is a growing fi eld that investigates semiotic processes in the living realm in an attempt to combine the fi ndings of the biological sciences and semiotics. Semiotic processes are more or less what biologists have typically referred to as “
El-Hani, Charbel, Emmeche, Claus, Kull, Kalevi, Queiroz, Joao   +3 more
core   +1 more source

Intratracheally Administered Pathogen-Associated Molecular Patterns Affect Antibody Responses of Poultry

Poultry Science, 2007
Various potential immune-modulating microbially derived pathogen-associated molecular patterns (PAMP), or so called homotopes, are present in high concentrations in the environment of food animals. In previous studies, intravenously administered PAMP had variable effects on specific primary and secondary immune responses of poultry to systemically ...
Ploegaert, T.C.W., de Vries Reilingh, G., Nieuwland, M.G.B., Lammers, A., Savelkoul, H.F.J., Parmentier, H.K.   +5 more
openaire   +3 more sources

ADP heptose, a novel pathogen‐associated molecular pattern identified in Helicobacter pylori [PDF]

The FASEB Journal, 2019
ABSTRACT The gastric pathogen Helicobacter pylori activates the NF‐κB pathway in human epithelial cells via the recently discovered α‐kinase 1 TRAF‐interacting protein with forkhead‐associated domain (TIFA) axis.
Pfannkuch, L., Hurwitz, R., Traulsen, J., Sigulla, J., Poeschke, M., Matzner, L., Kosma, P., Schmid, M., Meyer, T.   +8 more
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

Frontiers in Immunology, 2021
EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria.
Kuan-Yu I, Wen-Yi Tseng, Wen-Chih Wang, Siamon Gordon, Siamon Gordon, Kwai-Fong Ng, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin   +8 more
doaj   +1 more source

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Ivan Mikula Jr., Ivan Mikula Sr., Lucia Kisova, Mangesh Bhide, Michal Novak, Rastislav Mucha, Rostislav Skrabana   +6 more
core   +1 more source