Results 21 to 30 of about 861,453 (229)

Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease. [PDF]

Gastroenterology, 2022
IBD is characterized by defects in epithelial function and dysregulated inflammatory signaling by lamina propria mononuclear cells including macrophages and dendritic cells in response to microbiota.
Abraham C, Abreu MT, Turner JR.
europepmc   +2 more sources

Inhibitory pattern recognition receptors

Journal of Experimental Medicine, 2021
Pathogen- and damage-associated molecular patterns are sensed by the immune system’s pattern recognition receptors (PRRs) upon contact with a microbe or damaged tissue. In situations such as contact with commensals or during physiological cell death, the immune system should not respond to these patterns.
Matevž Rumpret, Helen J. von Richthofen, Victor Peperzak, Linde Meyaard   +3 more
openaire   +3 more sources

Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]

, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia, D’Eustachio, Peter, Masci, Anna Maria, Natale, Darren, Ruttenberg, Alan, Shamovsky, Veronica, Smith, Barry, Wu, Cathy   +7 more
core   +19 more sources

Toll9 from Bombyx mori functions as a pattern recognition receptor that shares features with Toll-like receptor 4 from mammals

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Toll/Toll-like receptors are key regulators of the innate immune system in both invertebrates and vertebrates. However, while mammalian Toll-like receptors function as pattern recognition receptors that directly bind microbe-associated ...
Ruonan Zhang, Xiaofeng Li, Jie Zhang, Yanjun Li, Yuan Wang, Yuhang Song, Feifei Ren, Huiyu Yi, Xiaojuan Deng, Yangjin Zhong, Yang Cao, M. Strand, Xiao-qiang Yu, Wanying Yang   +13 more
semanticscholar   +1 more source

Pattern recognition receptors

Japanese Journal of Clinical Immunology, 2011
Immunity is based on self/nonself discrimination. In vertebrates, two major systems, innate and adaptive immune systems, constitute host defense against invading microbes. Adaptive immunity is characterized by specific immune responses through B- or T-cell antigen receptors that are generated by somatic recombination, whereas nonspecific responses to ...
Takaya, Hayashi, Tohru, Nakamura, Akinori, Takaoka   +2 more
openaire   +4 more sources

Pattern Recognition Receptors and Autophagy [PDF]

Frontiers in Immunology, 2014
The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control immune responses.
Oh, JE Oh, Ji Eun, Lee, HK Lee, Heung Kyu   +1 more
openaire   +4 more sources

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
core   +5 more sources

C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement OveractivationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background and aims: C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI).
Hai-Yun Li, Zhao-Ming Tang, Zhe Wang, Jian-Min Lv, Xiao-Ling Liu, Yu-Lin Liang, Bin Cheng, Ning Gao, Shang-Rong Ji, Yi Wu   +9 more
doaj   +1 more source

The innate immune receptor Nlrp12 suppresses autoimmunity to the retina

Journal of Neuroinflammation, 2022
Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined.
Ellen J. Lee, Ruth J. Napier, Emily E. Vance, Sydney J. Lashley, Agnieszka D. Truax, Jenny P. Ting, Holly L. Rosenzweig   +6 more
doaj   +1 more source

Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1

Cells, 2021
Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy.
Yulin Ouyang, Li Wen, Jane A. Armstrong, Michael Chvanov, Diane Latawiec, Wenhao Cai, Mohammad Awais, Rajarshi Mukherjee, Wei Huang, Peter J. Gough, John Bertin, Alexei V. Tepikin, Robert Sutton, David N. Criddle   +13 more
doaj   +1 more source