Results 31 to 40 of about 861,453 (229)
CLEC5A: A Promiscuous Pattern Recognition Receptor to Microbes and Beyond. [PDF]
Adv Exp Med Biol, 2020 CLEC5A is a spleen tyrosine kinase (Syk)-coupled C-type lectin that is highly expressed by monocytes, macrophages, neutrophils, and dendritic cells and interacts with virions directly, via terminal fucose and mannose moieties of viral glycans.
Sung PS, Chang WC, Hsieh SL.
europepmc +2 more sources
Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2
eLife, 2022 C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji +12 more
doaj +1 more source
Autophagy, 2020 DDX58/RIG-I, is a critical pattern recognition receptor for viral RNA, which plays an essential role in antiviral immunity. Its posttranslational modifications and stability are tightly regulated to mediate the moderate production of type I IFN to ...
Huifang Xian +4 more
semanticscholar +1 more source
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Cell Reports, 2014 Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger +15 more
doaj +1 more source
Pattern Recognition Receptors and Inflammation [PDF]
Cell, 2010 Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors.
Takeuchi, Osamu, Akira, Shizuo
openaire +2 more sources
Cell Reports, 2017 Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM).
Kenta Moriwaki +4 more
doaj +1 more source
The Arabidopsis Malectin-Like/LRR-RLK IOS1 is Critical for BAK1-Dependent and BAK1-Independent Pattern-Triggered Immunity [PDF]
, 2016 Plasma membrane-localized pattern recognition receptors (PRRs) such as FLAGELLIN SENSING2 (FLS2), EF-TU RECEPTOR (EFR) and CHITIN ELICITOR RECEPTOR KINASE 1 (CERK1) recognize microbe-associated molecular patterns (MAMPs) to activate pattern-triggered ...
Chien, Hsiao-Chiao +11 more
core +1 more source
Cell Reports, 2016 Microvascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment, yet endothelial cells respond rapidly to vasoactive substances, including thrombin, allowing ...
Linda R. Klei +18 more
doaj +1 more source
Fisheries and Aquatic Sciences, 2022 Galectins, a family of β-galactoside-binding lectins, have emerged as soluble mediators in infected cells and pattern recognition receptors (PRRs) responsible for evoking and regulating innate immunity.
Chaehyeon Lim, Hyukjae Kwon, Jehee Lee
doaj +1 more source
Identifying the Patterns of Pattern Recognition Receptors [PDF]
Immunity, 2018 Intestinal homeostasis requires microbial recognition that results in appropriate responses to commensals and pathogens. In this issue of Immunity, Price et al. (2018) map the in vivo expression of five toll-like receptors (TLR) in intestinal epithelia, revealing distinct spatio-temporal expression patterns that shape responses to TLR ligands.
Andrea A, Hill, Gretchen E, Diehl
openaire +2 more sources