Results 1 to 10 of about 455,908 (138)
Anticancer properties of peptide fragments of hair proteins. [PDF]
PLoS One, 2014 The primary function of hair and fur covering mammalian skin is to provide mechanical and thermal protection for the body. The proteins that constitute hair are extremely resistant to degradation by environmental factors. However, even durable materials can be slowly broken down by mechanical stresses, biodegradation mediated by endogenous enzymes in ...
Markowicz S +9 more
europepmc +6 more sources
Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles [PDF]
, 2012 Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and ...
Antonia Vlahou +43 more
core +20 more sources
Fragmentation of amidinated peptide ions [PDF]
Journal of the American Society for Mass Spectrometry, 2004 The collision-induced dissociation characteristics of amidinated and unmodified tryptic peptides are compared using an ion trap mass spectrometer with both electrospray ionization and matrix-assisted laser/desorption ionization (MALDI). Several fragmentation pathways in a number of tryptic peptides of various precursor charge states are found to be ...
Richard L. Beardsley, James P. Reilly
openaire +3 more sources
Signature Fragment Ions of Biotinylated Peptides [PDF]
Journal of the American Society for Mass Spectrometry, 2020 The use of biotin or biotin-containing reagents is an essential component of many protein purification and labeling technologies. Owing to its small size and high affinity to the avidin family of proteins, biotin is a versatile molecular handle that permits both enrichment and purity that is not easily achieved by other reagents. Traditionally, the use
Dae In Kim +16 more
openaire +4 more sources
Light-Induced Orthogonal Fragmentation of Crosslinked Peptides [PDF]
JACS Au, 2023 Crosslinking mass spectrometry provides pivotal information on the structure and interaction of proteins. MS-cleavable crosslinkers are regarded as a cornerstone for the analysis of complex mixtures. Yet they fragment under similar conditions as peptides, leading to mixed fragmentation spectra of the crosslinker and peptide.
Lars Kolbowski +4 more
openaire +4 more sources
Fragment synthesis of disulfide-containing peptides
MethodsX, 2020 A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are:•Simple.•Low cost.•Solid phase based.
Hai Qian +3 more
openaire +3 more sources
Active Transport of Peptides Across the Intact Human Tympanic Membrane. [PDF]
, 2018 We previously identified peptides that are actively transported across the intact tympanic membrane (TM) of rats with infected middle ears. To assess the possibility that this transport would also occur across the human TM, we first developed and ...
Alexander, Thomas +9 more
core +1 more source
Folding propensities of peptide fragments of myoglobin [PDF]
Protein Science, 1997 Myoglobin has been studied extensively as a paradigm for protein folding. As part of an ongoing study of potential folding initiation sites in myoglobin, we have synthetized a series of peptides covering the entire sequence of sperm whale myoglobin. We report here on the conformation preferences of a series of peptides that cover the region from the A ...
M T Reymond +3 more
openaire +3 more sources
Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent [PDF]
, 2007 The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has been studied in methanol. The peptide FFKLVFF is based on A beta(16-20) extended at the N terminus by two phenylalanine residues.
Castelletto, Valeria +2 more
core +1 more source
A Dynamic Programming Approach to De Novo Peptide Sequencing via Tandem Mass Spectrometry [PDF]
, 2001 The tandem mass spectrometry fragments a large number of molecules of the same peptide sequence into charged prefix and suffix subsequences, and then measures mass/charge ratios of these ions.
Chen, Ting +4 more
core +3 more sources