Effects of Aβ-derived peptide fragments on fibrillogenesis of Aβ [PDF]
Scientific Reports, 2021 Amyloid β (Aβ) peptide aggregation plays a central role in Alzheimer’s disease (AD) etiology. AD drug candidates have included small molecules or peptides directed towards inhibition of Aβ fibrillogenesis.
Faisal Abedin +2 more
doaj +3 more sources
Comparative studies for amyloid beta degradation: “Neprilysin vs insulysin”, “monomeric vs aggregate”, and “whole Aβ40 vs its peptide fragments” [PDF]
Biochemistry and Biophysics Reports, 2022 Amyloid beta (Aβ) proteins are produced from amyloid precursor protein cleaved by β- and γ-secretases, and are the main components of senile plaques pathologically found in Alzheimer's disease (AD) patient brains.
Dai Kato +5 more
doaj +2 more sources
Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin [PDF]
ChemistryOpen, 2022 Following the successful introduction of two benign solvents for cleaving protected acid peptide fragments from 2‐chlorotrityl chloride (2‐CTC) resin, there is a need to green the cleavage process for obtaining protected peptide amide fragments.
Dr. Othman Al Musaimi +2 more
doaj +2 more sources
Self-Assembly of Lipopeptides Containing Short Peptide Fragments Derived from the Gastrointestinal Hormone PYY3-36: From Micelles to Amyloid Fibrils. [PDF]
J Phys Chem B, 2019 We investigate the impact of lipidation on the self-assembly of two peptide fragments from the gastrointestinal peptide hormone PYY3–36. The lipopeptides C16IKPEAP and C16IKPEAPGE contain the first 6 and 8 amino acid residues, respectively, from the PYY3–
Hutchinson JA +5 more
europepmc +2 more sources
Tracking the Amide I and αCOO− Terminal ν(C=O) Raman Bands in a Family of l-Glutamic Acid-Containing Peptide Fragments: A Raman and DFT Study [PDF]
Molecules, 2021 The E-hook of β-tubulin plays instrumental roles in cytoskeletal regulation and function. The last six C-terminal residues of the βII isotype, a peptide of amino acid sequence EGEDEA, extend from the microtubule surface and have eluded characterization ...
Ashley E. Williams +3 more
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Coordination Environment of Cu(II) Ions Bound to N-Terminal Peptide Fragments of Angiogenin Protein. [PDF]
Int J Mol Sci, 2016 Angiogenin (Ang) is a potent angiogenic factor, strongly overexpressed in patients affected by different types of cancers. The specific Ang cellular receptors have not been identified, but it is known that Ang–actin interaction induces changes both in ...
Magrì A +8 more
europepmc +2 more sources
Highly amyloidogenic two-chain peptide fragments are released upon partial digestion of insulin with pepsin. [PDF]
J Biol Chem, 2015 Background: Insulin is a model amyloidogenic protein. Results: Limited proteolysis of bovine insulin dimers with pepsin releases highly fibrillation-prone two-chain fragments.
Piejko M +6 more
europepmc +2 more sources
Anticancer properties of peptide fragments of hair proteins. [PDF]
PLoS ONE, 2014 The primary function of hair and fur covering mammalian skin is to provide mechanical and thermal protection for the body. The proteins that constitute hair are extremely resistant to degradation by environmental factors.
Sergiusz Markowicz +9 more
doaj +2 more sources
Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission. [PDF]
Front Immunol, 2021 Mariotton J +11 more
europepmc +3 more sources
SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting. [PDF]
Proc Natl Acad Sci U S AZhang Y +34 more
europepmc +3 more sources